个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共30条记录   In Vivo Adipogenesis in Rats Measured by Cell Kinetics in Adipocytes and Plastic-Adherent Stroma-Vascular Cells in Response to High-Fat Diet and Thiazolidinedione [作者：Tchoukalova, YD; Fitch, M; Rogers, PM; Covington, JD; Henagan, TM; Ye, JP; Hellerstein, MK; Ravussin, E,期刊：Diabetes, 页码：137-144 , 文章类型： Article，,卷期：2012年61-1] Impairment of adipogenesis contributes to the development of obesity-related insulin resistance. The current in vitro approaches for its assessment represent crude estimates of the adipogenic potential because of the dis... Central Role for Interleukin-2 in Type 1 Diabetes [作者：Hulme, MA; Wasserfall, CH; Atkinson, MA; Brusko, TM,期刊：Diabetes, 页码：14-22 , 文章类型： Article，,卷期：2012年61-1] Type 1 diabetes presents clinically with overt hyperglycemia resulting from progressive immune-mediated destruction of pancreatic beta-cells and associated metabolic dysfunction. Combined genetic and immunological studie... Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleuldn-1 Blockade [作者：Ablamunits, V; Henegariu, O; Hansen, JB; Opare-Addo, L; Preston-Hurlburt, P; Santamaria, P; Mandrup-Poulsen, T; Herold, KC,期刊：Diabetes, 页码：145-154 , 文章类型： Article，,卷期：2012年61-1] Inflammatory cytokines are involved in autoimmune diabetes: among the most prominent is interleukin (IL)-1 beta. We postulated that blockade of IL-1 beta would modulate the effects of anti-CD3 monoclonal antibody (mAb) i... Distinguishing Persistent Insulin Autoantibodies With Differential Risk Nonradioactive Bivalent Proinsulin/Insulin Autoantibody Assay [作者：Yu, LP; Miao, DM; Scrimgeour, L; Johnson, K; Rewers, M; Eisenbarth, GS,期刊：Diabetes, 页码：179-186 , 文章类型： Article，,卷期：2012年61-1] A subset of children develops persistent insulin autoantibodies (IAA; almost always as the only islet autoantibody) without evidence of progression to diabetes. The aim of the current study was the development and charac... Na(+)-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose-Absorption and Glucose-Dependent Incretin Secretion [作者：Gorboulev, V; Schurmann, A; Vallon, V; Kipp, H; Jaschke, A; Klessen, D; Friedrich, A; Scherneck, S; Rieg, T; Cunard, R; Veyhl-Wichmann, M; Srinivasan, A; Balen, D; Breljak, D; Rexhepaj, R; Parker, HE; Gribble, FM; Reimann, F; Lang, F; Wiese, S; Sabolic, I; Sendtner, M; Koepsell, H,期刊：Diabetes, 页码：187-196 , 文章类型： Article，,卷期：2012年61-1] To clarify the physiological role of Na(+)-D-glucose cotransporter SGLT1 in small intestine and kidney, Sglt1(-/-) mice were generated and characterized phenotypically. After gavage of D-glucose, small intestinal glucose... Somatostatin Receptor Type 2 Antagonism Improves Glucagon and Corticosterone Counterregulatory Responses to Hypoglycemia in Streptozotocin-Induced Diabetic Rats [作者：Yue, JTY; Burdett, E; Coy, DH; Giacca, A; Efendic, S; Vranic, M,期刊：Diabetes, 页码：197-207 , 文章类型： Article，,卷期：2012年61-1] Diminished responsiveness to hypoglycemia contributes to defective counterregulation in diabetes. Pancreatic and/or circulating somatostatin are elevated in diabetes, which may inhibit counterregulatory hormone release d... Sirtuin 1-Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin [作者：Zheng, Z; Chen, HB; Li, J; Li, T; Zheng, BQ; Zheng, Y; Jin, HY; He, Y; Gu, Q; Xu, X,期刊：Diabetes, 页码：217-228 , 文章类型： Article，,卷期：2012年61-1] Cellular metabolic memory occurs in diabetic microvascular and macrovascular complications, but the underlying mechanisms remain unclear. Here, we investigate the role of sirtuin 1 (SIRT1) and metformin in this phenomeno... Nerve Growth Factor Gene Therapy Using Adeno-Associated Viral Vectors Prevents Cardiomyopathy in Type 1 Diabetic Mice [作者：Meloni, M; Descamps, B; Caporali, A; Zentilin, L; Floris, I; Giacca, M; Emanueli, C,期刊：Diabetes, 页码：229-240 , 文章类型： Article，,卷期：2012年61-1] Diabetes is a cause of cardiac dysfunction, reduced myocardial perfusion, and ultimately heart failure. Nerve growth factor (NGF) exerts protective effects on the cardiovascular system. This study investigated whether NG... Nutrient Sensing, Autophagy, and Diabetic Nephropathy [作者：Kume, S; Thomas, MC; Koya, D,期刊：Diabetes, 页码：23-29 , 文章类型： Article，,卷期：2012年61-1] The prevalence of diabetic nephropathy, a serious complication of diabetes, has been increasing worldwide. Therefore, there is an urgent need to identify a new therapeutic target to prevent diabetic nephropathy. "Nutrien... The ATP-Sensitive K(+) Channel ABCC8 S1369A Type 2 Diabetes Risk Variant Increases MgATPase Activity [作者：Fatehi, M; Raja, M; Carter, C; Soliman, D; Holt, A; Light, PE,期刊：Diabetes, 页码：241-249 , 文章类型： Article，,卷期：2012年61-1] Pancreatic beta-cell ATP-sensitive K(+) (K(ATP)) channels are composed of Kir6.2 and SUR1 subunits encoded by the KCNJ11 and ABCC8 genes, respectively. Although rare monogenic activating mutations in these genes cause ov... Gipr Is Essential for Adrenocortical Steroidogenesis, However, Corticosterone Deficiency Does Not Mediate the Favorable Metabolic Phenotype of Gipr(-/-) Mice [作者：Bates, HE; Campbell, JE; Ussher, JR; Baggio, LL; Maida, A; Seino, Y; Drucker, DJ,期刊：Diabetes, 页码：40-48 , 文章类型： Article，,卷期：2012年61-1] Glucose-dependent insulinotropic polypeptide (GIP) promotes glucose-dependent insulin secretion. However, GIP also enhances glucocorticoid secretion and promotes adiposity. Because obesity and diabetes are glucocorticoid... A Novel Mechanism for Regulating Hepatic Glycogen Synthesis Involving Serotonin and Cyclin-Dependent Kinase-5 [作者：Tudhope, SJ; Wang, CC; Petrie, JL; Potts, L; Malcomson, F; Kieswich, J; Yaqoob, MM; Arden, C; Hampson, LJ; Agius, L,期刊：Diabetes, 页码：49-60 , 文章类型： Article，,卷期：2012年61-1] Hepatic autonomic nerves regulate postprandial hepatic glucose uptake, but the signaling pathways remain unknown. We tested the hypothesis that serotonin (5-hydroxyhyptamine [5-HT]) exerts stimulatory and inhibitory effe... Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation [作者：Kimura, K; Yamada, T; Matsumoto, M; Kido, Y; Hosooka, T; Asahara, S; Matsuda, T; Ota, T; Watanabe, H; Sai, Y; Miyamoto, K; Kaneko, S; Kasuga, M; Inoue, H,期刊：Diabetes, 页码：61-73 , 文章类型： Article，,卷期：2012年61-1] In the liver, signal transducer and activator of transcription 3 (STAT3) plays an important role in the suppression of gluconeogenic enzyme expression. While obesity-associated endoplasmic reticulum (ER) stress has been ... Remodeling of Hepatic Metabolism and Hyperaminoacidemia in Mice Deficient in Proglucagon-Derived Peptides [作者：Watanabe, C; Seino, Y; Miyahira, H; Yamamoto, M; Fukami, A; Ozaki, N; Takagishi, Y; Sato, J; Fukuwatari, T; Shibata, K; Oiso, Y; Murata, Y; Hayashi, Y,期刊：Diabetes, 页码：74-84 , 文章类型： Article，,卷期：2012年61-1] Glucagon is believed to be one of the most important peptides for upregulating blood glucose levels. However, homozygous glucagon green fluorescent protein (gfp) knock-in mice (Gcg(gfp/gfp): GCGKO) are normoglycemic desp... Hypothalamic Leucine Metabolism Regulates Liver Glucose Production [作者：Su, Y; Lam, TKT; He, W; Pocai, A; Bryan, J; Aguilar-Bryan, L; Gutierrez-Juarez, R,期刊：Diabetes, 页码：85-93 , 文章类型： Article，,卷期：2012年61-1] Amino acids profoundly affect insulin action and glucose metabolism in mammals. Here, we investigated the role of the mediobasal hypothalamus (MBH), a key center involved in nutrient-dependent metabolic regulation. Speci... Targeted Loss of GHR Signaling in Mouse Skeletal Muscle Protects Against High-Fat Diet Induced Metabolic Deterioration [作者：Vijayakumar, A; Wu, YJ; Sun, H; Li, XS; Jeddy, Z; Liu, CY; Schwartz, GJ; Yakar, S; LeRoith, D,期刊：Diabetes, 页码：94-103 , 文章类型： Article，,卷期：2012年61-1] Growth hormone (GH) exerts diverse tissue-specific metabolic effects that are not revealed by global alteration of GH action. To study the direct metabolic effects of GH in the muscle, we specifically inactivated the gro...