- Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury
[作者:Isenberg, JS; Maxhimer, JB; Hyodo, F; Perndrak, ML; Ridnour, LA; DeGraff, WG; Tsokos, M; Wink, DA; Roberts, DD,期刊:American Journal of Pathology, 页码:1100-1112 , 文章类型: Article,,卷期:2008年173-4]
- Radiation, a primary mode of cancer therapy, acutely damages cellular macromolecules and DNA and elicits stress responses that lead to cell death. The known cytoprotective activity of nitric oxide (NO) is blocked by thro...
- A novel missense mutation in the second extracellular domain of GJB2, p.Ser183Phe, causes a syndrome of focal palmoplantar keratoderma with deafness
[作者:de Zwart-Storm, EA; van Geel, M; van Neer, PAFA; Steijlen, PM; Martin, PE; van Steensel, MAM,期刊:American Journal of Pathology, 页码:1113-1119 , 文章类型: Article,,卷期:2008年173-4]
- Gap junctions, which consist of connexins, are intercellular channels that mediate rapid intercellular communication. in the skin, connexins are involved in the regulation of epidermal growth and differentiation. GJB2 en...
- Gastrointestinal dysmotility in mitochondrial neurogastrointestinal encephalomyopathy is caused by mitochondrial DNA depletion
[作者:Giordano, C; Sebastiani, M; De Giorgio, R; Travaglini, C; Tancredi, A; Valentino, ML; Bellan, M; Cossarizza, A; Hirano, M; d'Amati, G; Carelli, V,期刊:American Journal of Pathology, 页码:1120-1128 , 文章类型: Article,,卷期:2008年173-4]
- Chronic intestinal pseudo-obstruction is a life-threatening condition of unknown pathogenic mechanisms. Chronic intestinal pseudo-obstruction can be a feature of mitochondrial disorders, such as mitochondrial neurogastro...
- Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air - A potential mechanism underlying adult respiratory distress syndrome
[作者:Gongora, MC; Lob, HE; Landmesser, U; Guzik, TJ; Martin, WD; Ozumi, K; Wall, SM; Wilson, DS; Murthy, N; Gravanis, M; Fukai, T; Harrison, DG,期刊:American Journal of Pathology, 页码:915-926 , 文章类型: Article,,卷期:2008年173-4]
- The extracellular superoxide dismutase 3 (SOD3) is highly expressed in both blood vessels and lungs. in different models of pulmonary injury, SOD3 is reduced; however, it is unclear whether this contributes to lung injur...
- Deletion of Cd151 results in a strain-dependent glomerular disease due to severe alterations of the glomerular basement membrane
[作者:Baleato, RM; Guthrie, PL; Gubler, MC; Ashman, LK; Roselli, S,期刊:American Journal of Pathology, 页码:927-937 , 文章类型: Article,,卷期:2008年173-4]
- Alterations in CD151 have been associated with primary glomerular disease in both humans and mice, implicating CD151 as a key component of the glomerular filtration barrier. CD151 belongs to the tetraspanin family and as...
- Vascular endothelial growth factor-C, a potential paracrine regulator of glomerular permeability, increases glomerular endothelial cell monolayer integrity and intracellular calcium
[作者:Foster, RR; Slater, SC; Seckley, J; Kerjaschki, D; Bates, DO; Mathieson, PW; Satchell, SC,期刊:American Journal of Pathology, 页码:938-948 , 文章类型: Article,,卷期:2008年173-4]
- We have previously reported expression of vascular endothelial growth factor (VEGF)-A and -C in glomerular podocytes and actions of VEGF-A on glomerular endothelial cells (GEnC) that express VEGF receptor-2 (VEGFR-2). He...
- CX3CL1 up-regulation is associated with recruitment of CX3CR1(+) mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema
[作者:McComb, JG; Ranganathan, M; Liu, XH; Pilewski, JM; Ray, P; Watkins, SC; Choi, AMK; Lee, JS,期刊:American Journal of Pathology, 页码:949-961 , 文章类型: Article,,卷期:2008年173-4]
- CX3CR1 is expressed on monocytes, dendritic cells, macrophages, subsets of T Lymphocytes, and natural killer cells and functions in diverse capacities such as leukocyte adhesion, migration, and cell survival on ligand bi...
- Differential roles of JNK in ConA/GaIN and ConA-induced liver injury in mice
[作者:Ni, HM; Chen, X; Ding, WX; Schuchmann, M; Yin, XM,期刊:American Journal of Pathology, 页码:962-972 , 文章类型: Article,,卷期:2008年173-4]
- Tumor necrosis factor-a-mediated liver injury can file induced by several different means; however, the signaling events and mechanisms of cell death are likely different. We investigated the mechanism of both apoptotic ...
- Gene silencing of complement C5a receptor using siRNA for preventing ischemia/reperfusion injury
[作者:Zheng, XF; Zhang, XS; Feng, BA; Sun, HT; Suzuki, M; Ichim, T; Kubo, N; Wong, A; Min, LR; Budohn, ME; Garcia, B; Jevnikar, AM; Min, WP,期刊:American Journal of Pathology, 页码:973-980 , 文章类型: Article,,卷期:2008年173-4]
- Ischemia/reperfusion (I/R) injury in organ transplantation significantly contributes to graft failure and is untreatable using current approaches. I/R injury is associated with activation of the complement system, leadin...
- Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans
[作者:Almolki, A; Guenegou, A; Golda, S; Boyer, L; Benallaoua, M; Amara, N; Bachoual, R; Lanone, S; Dulak, J; Burgel, PR; El-Benna, J; Leynaert, AB; Aubier, M; Boczkowski, J,期刊:American Journal of Pathology, 页码:981-992 , 文章类型: Article,,卷期:2008年173-4]
- We investigated the role of heme oxygenase-1 (HO-1), a powerful anti-inflammatory and anti-oxidant enzyme, in modulating cigarette smoke (CS)-induced mucus secretion. In both rats and mice, 5-day CS exposure increased HO...
- Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis
[作者:DeLeve, LD; Wang, XD; Kanel, GC; Atkinson, RD; McCuskey, RS,期刊:American Journal of Pathology, 页码:993-1001 , 文章类型: Article,,卷期:2008年173-4]
- The endocannabinoid pathway plays an important role in the regulation of appetite and body weight, hepatic lipid metabolism, and fibrosis. Blockade of the endocannabinoid receptor CBI with SR141716 promotes weight loss, ...
- Nitric oxide regulates tumor cell cross-talk with stromal cells in the tumor microenvironment of the liver
[作者:Decker, NK; Abdelmoneim, SS; Yaqoob, U; Hendrickson, H; Hormes, J; Bentley, M; Pitot, H; Urrutia, R; Gores, GJ; Shah, VH,期刊:American Journal of Pathology, 页码:1002-1012 , 文章类型: Article,,卷期:2008年173-4]
- Tumor progression is regulated through paracrine interactions between tumor cells and stromal cells in the microenvironment, including endothelial cells and myofibroblasts. Nitric oxide (NO) is a key molecule in the regu...
- Nuclear factor-kappa B is a critical mediator of Ste20-like proline-/alanine-rich kinase regulation in intestinal inflammation
[作者:Yan, Y; Dalmasso, G; Nguyen, HTT; Obertone, TS; Charrier-Hisamuddin, L; Sitaraman, SV; Merlin, D,期刊:American Journal of Pathology, 页码:1013-1028 , 文章类型: Article,,卷期:2008年173-4]
- Inflammatory bowel disease (IBD) is thought to result from commensal flora, aberrant cellular stress, and genetic factors. Here we show that the expression of colonic Ste20-like proline-/alanine-rich kinase (SPAK) that l...
- Absence of the cellular prion protein exacerbates and prolongs neuroinflammation in experimental autoimmune encephalomyelitis
[作者:Tsutsui, S; Hahn, JN; Johnson, TA; Ali, Z; Jirik, FR,期刊:American Journal of Pathology, 页码:1029-1041 , 文章类型: Article,,卷期:2008年173-4]
- Although the physiological roles of the cellular prion protein (PrPC) remain to be fully elucidated, PrPC has been proposed to represent a potential regulator of cellular immunity. To test this hypothesis, we evaluated t...
- Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2
[作者:Hinek, A; Bodnaruk, TD; Bunda, S; Wang, YT; Liu, K,期刊:American Journal of Pathology, 页码:1042-1056 , 文章类型: Article,,卷期:2008年173-4]
- We recently established that the elastin-binding protein, which is identical to the spliced variant of beta-galactosidase, forms a cell surface-targeted complex with two proteins considered "classic lysosomal enzymes": p...
|