- Adjuvant effect of cationic liposomes and CpG depends on administration route
[作者:Slutter, B; Bal, SM; Ding, Z; Jiskoot, W; Bouwstra, JA,期刊:Journal of controlled release, 页码:123-130 , 文章类型: Article,,卷期:2011年154-2]
- In this study we explored the immunization route-dependent adjuvanticity of cationic liposomes loaded with an antigen (ovalbumin; OVA) and an immune potentiator (CpG). Mice were immunized intranodally, intradermally, tra...
- Local transdermal delivery of phenylephrine to the anal sphincter muscle using microneedles
[作者:Baek, C; Han, M; Min, J; Prausnitz, MR; Park, JH; Park, JH,期刊:Journal of controlled release, 页码:138-147 , 文章类型: Article,,卷期:2011年154-2]
- We propose pretreatment using microneedles to increase perianal skin permeability for locally targeted delivery of phenylephrine (PE), a drug that increases resting anal sphincter pressure to treat fecal incontinence. Mi...
- Kinetics of skin resealing after insertion of microneedles in human subjects
[作者:Gupta, J; Gill, HS; Andrews, SN; Prausnitz, MR,期刊:Journal of controlled release, 页码:148-155 , 文章类型: Article,,卷期:2011年154-2]
- Over the past decade, microneedles have been shown to dramatically increase skin permeability to a broad range of compounds by creating reversible microchannels in the skin. However, in order to achieve sustained transde...
- Development of tripartite polyion micelles for efficient peptide delivery into dendritic cells without altering their plasticity
[作者:Boudier, A; Aubert-Pouessel, A; Mebarek, N; Chavanieu, A; Quentin, J; Martire, D; Boukhaddaoui, H; Gerardin, C; Jorgensen, C; Devoisselle, JM; Louis-Plence, P; Begu, S,期刊:Journal of controlled release, 页码:156-163 , 文章类型: Article,,卷期:2011年154-2]
- For many years, a great deal of interest has been focusing on the optimization of peptide presentation by dendritic cells (DCs) using peptide-encapsulated particles, in order to enhance the immune response. Nowadays, DCs...
- Poly(beta-amino ester)-DNA complexes: Time-resolved fluorescence and cellular transfection studies
[作者:Vuorimaa, E; Ketola, TM; Green, JJ; Hanzlikova, M; Lemmetyinen, H; Langer, R; Anderson, DG; Urtti, A; Yliperttula, M,期刊:Journal of controlled release, 页码:171-176 , 文章类型: Article,,卷期:2011年154-2]
- A large number of different polymers have been developed and studied for application as DNA carriers for non-viral gene delivery, but the DNA binding properties are not understood. This study describes the efficiency of ...
- A novel glutathione modified chitosan conjugate for efficient gene delivery
[作者:Li, CX; Guo, TY; Zhou, DZ; Hu, YL; Zhou, H; Wang, SF; Chen, JT; Zhang, ZP,期刊:Journal of controlled release, 页码:177-188 , 文章类型: Article,,卷期:2011年154-2]
- A novel non-viral gene vector based on poly[poly(ethylene glycol) methacrylate] (PMPEG) and L-glutathione (GSH) grafted chitosan (CS) has been fabricated. First, well-defined brush-like PMPEG living polymers with dithioe...
- Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury
[作者:Furukawa, M; Tanaka, R; Chuang, VTG; Ishima, Y; Taguchi, K; Watanabe, H; Maruyama, T; Otagiri, M,期刊:Journal of controlled release, 页码:189-195 , 文章类型: Article,,卷期:2011年154-2]
- Thioredoxin (Trx) is a redox-active protein with anti-inflammatory effects but with a short half life of 1 h. Genetic fusion of Trx to human serum albumin (HSA) extended its half life without causing significant loss of ...
- Improved paramagnetic liposomes for MRI visualization of pH triggered release
[作者:Torres, E; Mainini, F; Napolitano, R; Fedeli, F; Cavalli, R; Aime, S; Terreno, E,期刊:Journal of controlled release, 页码:196-202 , 文章类型: Article,,卷期:2011年154-2]
- This work aims at assessing the in vitro potential of paramagnetic pH sensitive liposomes as imaging tools for visualizing drug-delivery and release processes by Magnetic Resonance Imaging (MRI). pH sensitive liposomes (...
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