- Advances in oral transmucosal drug delivery
[作者:Patel, VF; Liu, F; Brown, MB,期刊:Journal of controlled release, 页码:106-116 , 文章类型: Review,,卷期:2011年153-2]
- The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity. Oral transmucosal delivery, especially buccal and sublingual delivery, has progressed far beyond ...
- Novel micelle formulations to increase cutaneous bioavailability of azole antifungals
[作者:Bachhav, YG; Mondon, K; Kalia, YN; Gurny, R; Moller, M,期刊:Journal of controlled release, 页码:126-132 , 文章类型: Article,,卷期:2011年153-2]
- Efficient topical drug administration for the treatment of superficial fungal infections would deliver the therapeutic agent to the target compartment and reduce the risk of systemic side effects. However, the physicoche...
- Porous hydroxyapatite scaffold with three-dimensional localized drug delivery system using biodegradable microspheres
[作者:Son, JS; Appleford, M; Ong, JL; Wenke, JC; Kim, JM; Choi, SH; Oh, DS,期刊:Journal of controlled release, 页码:133-140 , 文章类型: Article,,卷期:2011年153-2]
- In this study, ionic immobilization of dexamethasone (DEX)-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres was performed on the hydroxyapatite (HAp) scaffold surfaces. It was hypothesized that in vivo bone regen...
- An effective gene-knockdown using multiple shRNA-expressing adenovirus vectors
[作者:Motegi, Y; Katayama, K; Sakurai, F; Kato, T; Yamaguchi, T; Matsui, H; Takahashi, M; Kawabata, K; Mizuguchi, H,期刊:Journal of controlled release, 页码:149-153 , 文章类型: Article,,卷期:2011年153-2]
- Viral vectors expressing short hairpin RNA (shRNA) are attractive for efficient and tissue-specific RNA interference (RNAi) delivery. We and others previously reported that recombinant adenovirus (Ad) vector-mediated RNA...
- Delivery of a cocktail DNA vaccine encoding cysteine proteinases type I, II and III with solid lipid nanoparticles potentiate protective immunity against Leishmania major infection
[作者:Doroud, D; Zahedifard, F; Vatanara, A; Najafabadi, AR; Taslimi, Y; Vahabpour, R; Torkashvand, F; Vaziri, B; Rafati, S,期刊:Journal of controlled release, 页码:154-162 , 文章类型: Article,,卷期:2011年153-2]
- Earlier generations of Leishmania vaccines have reached the third-phase of clinical trials, however none of them have shown adequate efficacy due to lack of an appropriate adjuvant. In this study, cationic solid lipid na...
- Hyperthermia-triggered intracellular delivery of anticancer agent to HER2(+) cells by HER2-specific affibody (ZHER2-GS-Cys)-conjugated thermosensitive liposomes (HER2(+) affisomes)
[作者:Smith, B; Lyakhov, I; Loomis, K; Needle, D; Baxa, U; Yavlovich, A; Capala, J; Blumenthal, R; Puri, A,期刊:Journal of controlled release, 页码:187-194 , 文章类型: Article,,卷期:2011年153-2]
- We previously reported the formulation and physical properties of HER2 (human epidermal growth factor receptor 2)-specific affibody (ZHER2:342-Cys) conjugated thermosensitive liposomes (HER2(+) affisomes). Here we examin...
- Penetration without cells: Membrane translocation of cell-penetrating peptides in the model giant plasma membrane vesicles
[作者:Saalik, P; Niinep, A; Pae, J; Hansen, M; Lubenets, D; Langel, U; Pooga, M,期刊:Journal of controlled release, 页码:117-125 , 文章类型: Article,,卷期:2011年153-2]
- The cellular internalization of cell-penetrating peptides (CPPs) is proposed to take place by both endocytic processes and by a direct translocation across the plasma membrane. So far only scarce data is available about ...
- Insights into the cellular trafficking of splice redirecting oligonucleotides complexed with chemically modified cell-penetrating peptides
[作者:Hassane, FS; Abes, R; El Andaloussi, S; Lehto, T; Sillard, R; Langel, U; Lebleu, B,期刊:Journal of controlled release, 页码:163-172 , 文章类型: Article,,卷期:2011年153-2]
- Conjugates of cell-penetrating peptides (CPP) and splice redirecting oligonucleotides (ON) display clinical potential as attested by in vivo experimentation in murine models of Duchenne muscular dystrophy. However, micro...
- Conformational consequences of cooperative binding of a coiled-coil peptide motif to poly(N-(2-hydroxypropyl) methacrylamide) HPMA copolymers
[作者:Griffiths, PC; Paul, A; Apostolovic, B; Klok, HA; de Luca, E; King, SM; Heenan, RK,期刊:Journal of controlled release, 页码:173-179 , 文章类型: Article,,卷期:2011年153-2]
- Small-angle neutron scattering and pulsed-gradient spin-echo NMR have been used to examine the solution conformation of a series of water soluble poly(N-(2-hydroxypropyl) methacrylamide) P(HPMA) co-polymer drug delivery ...
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