- Rational design of biodegradable cationic polycarbonates for gene delivery
[作者:Ong, ZY; Fukushima, K; Coady, DJ; Yang, YY; Ee, PLR; Hedrick, JL,期刊:Journal of controlled release, 页码:120-126 , 文章类型: Article,,卷期:2011年152-1]
- Polycarbonates provide an attractive option for use as gene delivery vectors owing to their biocompatibility and ease of incorporating functional moieties. In this study, we described an approach to synthesize cationic p...
- Biodegradable mPEG-b-P(MCC-g-OEI) copolymers for efficient gene delivery
[作者:Dong, X; Tian, HY; Chen, L; Chen, J; Chen, XS,期刊:Journal of controlled release, 页码:135-142 , 文章类型: Article,,卷期:2011年152-1]
- Cationic polymers play an important role in gene delivery. To search for potential non-viral gene carriers, a series of biodegradable cationic polymers, poly(ethylene glycol)-block-poly(carbonates-graft-oligoethylenimine...
- Bioreducible polymers with cell penetrating and endosome buffering functionality for gene delivery systems
[作者:Kim, T; Rothmund, T; Kissel, T; Kim, SW,期刊:Journal of controlled release, 页码:110-119 , 文章类型: Article,,卷期:2011年152-1]
- Bioreducible cationic polymers (p(DAH(a)-R/API(b))s) composed of different ratios (a:b=2:1, 1:1, 1:2) between arginine-grafted diaminohexane (DAH-R) (cell penetrating functionality) and 1-(3-aminopropyl) imidazole (API) ...
- Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery
[作者:Cheng, R; Feng, F; Meng, FH; Deng, C; Jan, FJ; Zhong, ZY,期刊:Journal of controlled release, 页码:2-12 , 文章类型: Article,,卷期:2011年152-1]
- The past couple of years have witnessed a tremendous progress in the development of glutathione-responsive nano-vehicles for targeted intracellular drug and gene delivery, as driven by the facts that (i) many therapeutic...
- Hydrotropic polymer micelles as versatile vehicles for delivery of poorly water-soluble drugs
[作者:Kim, JY; Kim, S; Pinal, R; Park, K,期刊:Journal of controlled release, 页码:13-20 , 文章类型: Article,,卷期:2011年152-1]
- Polymer micelles have been used widely for delivery of poorly water-soluble drugs. Such drug delivery, however, has been based primarily on hydrophobic interactions. For better drug loading and improved stability, hydrot...
- Revisit complexation between DNA and polyethylenimine - Effect of length of free polycationic chains on gene transfection
[作者:Yue, YA; Jin, F; Deng, R; Cai, JG; Dai, ZJ; Lin, MCM; Kung, HF; Mattebjerg, MA; Andresen, TL; Wu, C,期刊:Journal of controlled release, 页码:143-151 , 文章类型: Article,,卷期:2011年152-1]
- Our revisit of the complexation between DNA and polyethylenimine (PEI) by using a combination of laser light scattering and gel electrophoresis confirms that nearly all the DNA chains are complexed with PEI to form polyp...
- Multi-responsive nanogels containing motifs of ortho ester, oligo(ethylene glycol) and disulfide linkage as carriers of hydrophobic anti-cancer drugs
[作者:Qiao, ZY; Zhang, R; Du, FS; Liang, DH; Li, ZC,期刊:Journal of controlled release, 页码:57-66 , 文章类型: Article,,卷期:2011年152-1]
- A family of multi-responsive nanogels with different compositions and crosslinking degrees have been prepared by the miniemulsion copolymerization of monomethyl oligo(ethylene glycol) acrylate (OEGA) and an ortho ester-c...
- Antibiotic-releasing porous polymethylmethacrylate/gelatin/antibiotic constructs for craniofacial tissue engineering
[作者:Shi, M; Kretlow, JD; Spicer, PP; Tabata, Y; Demian, N; Wong, ME; Kasper, FK; Mikos, AG,期刊:Journal of controlled release, 页码:196-205 , 文章类型: Article,,卷期:2011年152-1]
- An antibiotic-releasing porous polymethylmethacrylate (PMMA) construct was developed to maintain the bony space and prime the wound site in the initial step of a two-stage regenerative medicine approach toward reconstruc...
- Anti-tumor drug delivery of pH-sensitive poly(ethylene glycol)-poly(L-histidine-)-poly(L-lactide) nanoparticles
[作者:Liu, R; Li, D; He, B; Xu, XH; Sheng, MM; Lai, YS; Wang, G; Gu, ZW,期刊:Journal of controlled release, 页码:49-56 , 文章类型: Article,,卷期:2011年152-1]
- pH-sensitive poly(ethylene glycol)-poly(L-histidine)-poly(L-lactide) (PEG-PH-PLLA) nanoparticles were prepared and used as carriers for anti-tumor drug delivery. The morphology and properties of the nanoparticles such as...
- siRNA nanocarriers based on methacrylic acid copolymers
[作者:Felber, AE; Castagner, B; Elsabahy, M; Deleavey, GF; Damha, MJ; Leroux, JC,期刊:Journal of controlled release, 页码:159-167 , 文章类型: Article,,卷期:2011年152-1]
- Poly(ethylene glycol)-b-poly(propyl methacrylate-co-methacrylic acid) (PEG-b-P(PrMA-co-MAA) can be complexed with poly(amido amine) (PAMAM) dendrimers and nucleic acids to form pH-responsive nanosized core-shell type pol...
- Chondrogenesis in injectable enzymatically crosslinked heparin/dextran hydrogels
[作者:Jin, R; Teixeira, LSM; Dijkstra, PJ; van Blitterswijk, CA; Karperien, M; Jan, FJ,期刊:Journal of controlled release, 页码:186-195 , 文章类型: Article,,卷期:2011年152-1]
- In this study, injectable hydrogels were prepared by horseradish peroxidase-mediated co-crosslinking of dextran-tyramine (Dex-TA) and heparin-tyramine (Hep-TA) conjugates and used as scaffolds for cartilage tissue engine...
- From kidney development to drug delivery and tissue engineering strategies in renal regenerative medicine
[作者:Dankers, PYW; Boomker, JM; Meijer, EW; Popa, ER; van Luyn, MJA,期刊:Journal of controlled release, 页码:177-185 , 文章类型: Article,,卷期:2011年152-1]
- Deterioration of renal function is typically slow but progressive, and therefore renal disease is often diagnosed in a late stage when already serious complaints occur. Ultimately when renal function has dropped below 10...
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