- Vagrant Stem Cells Draft Their Gene Companions
[作者：Bonig, H; Papayannopoulou, T,期刊：Cell Stem Cell, 页码：547-548 , 文章类型： Editorial Material，,卷期：2010年7-5]
- In a recent issue of Nature Medicine, Ryan et al. (2010) uncover genetic modifiers of G-CSF responses by hematopoietic progenitors. The authors document a negative role of EGFR signaling and, provided an analogous pathwa...
- Extinction of Xist Improves Cloning
[作者：Tonge, PD; Nagy, A,期刊：Cell Stem Cell, 页码：550-552 , 文章类型： Editorial Material，,卷期：2010年7-5]
- Mammalian cloning by somatic cell nuclear transfer is a notoriously inefficient process with a low birth rate. Recently in Science, Inoue et al. (2010) report that somatic cell nuclear transfer fails to regulate Xist exp...
- Stem Cells and Osteoporosis Therapy
[作者：Teitelbaum, SL,期刊：Cell Stem Cell, 页码：553-554 , 文章类型： Editorial Material，,卷期：2010年7-5]
- Skeletal remodeling requires recruitment of osteoblast precursors, in the form of MSCs, to the bone surface. In this issue of Cell Stem Cell, Wu et al. (2010) demonstrate that this event is mediated by osteoclastic mobil...
- The Endless hESC Controversy in the United States: History, Context, and Prospects
[作者：Gottweis, H,期刊：Cell Stem Cell, 页码：555-558 , 文章类型： Editorial Material，,卷期：2010年7-5]
- Human embryonic stem cell research has faced a long, tough political battle in the United States. The article explores the history of this controversy and the motives behind it, leading up to the August 23, 2010 district...
- Different Flavors of Pluripotency, Molecular Mechanisms, and Practical Implications
[作者：Buecker, C; Geijsen, N,期刊：Cell Stem Cell, 页码：559-564 , 文章类型： Article，,卷期：2010年7-5]
- Pluripotent stem cells (PSCs) have been classified into two distinct states: a primitive, naive LIF-dependent state represented by murine ESCs, and a primed bFGF-dependent state observed in murine and rat epiblast stem c...
- Epigenetic Mechanisms that Regulate Cell Identity
[作者：Barrero, MJ; Boue, S; Belmonte, JCI,期刊：Cell Stem Cell, 页码：565-570 , 文章类型： Article，,卷期：2010年7-5]
- Individual cell fate decisions can vary according to changes in gene expression in response to environmental, developmental, or metabolic cues. This plasticity is tightly regulated during embryonic development and mediat...
- Inhibition of Sca-1-Positive Skeletal Stem Cell Recruitment by Alendronate Blunts the Anabolic Effects of Parathyroid Hormone on Bone Remodeling
[作者：Wu, XW; Pang, LJ; Lei, WQ; Lu, W; Li, J; Li, ZY; Frassica, FJ; Chen, XL; Wan, M; Cao, X,期刊：Cell Stem Cell, 页码：571-580 , 文章类型： Article，,卷期：2010年7-5]
- The anabolic effects of parathyroid hormone (PTH) on bone formation are impaired by concurrent use of antiresorptive drugs. We found that the release of active transforming growth factor (TGF)-beta 1 during osteoclastic ...
- mTOR Activation Induces Tumor Suppressors that Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells after Pten Deletion
[作者：Lee, JY; Nakada, D; Yilmaz, OH; Tothova, Z; Joseph, NM; Lim, MS; Gilliland, DG; Morrison, SJ,期刊：Cell Stem Cell, 页码：593-605 , 文章类型： Article，,卷期：2010年7-5]
- Pten deficiency depletes hematopoietic stem cells (HSCs) but expands leukemia-initiating cells, and the mTOR inhibitor, rapamycin, blocks these effects. Understanding the opposite effects of mTOR activation on HSCs versu...
- Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity
[作者：Abbas, HA; Maccio, DR; Coskun, S; Jackson, JG; Hazen, AL; Sills, TM; You, MJ; Hirschi, KK; Lozano, G,期刊：Cell Stem Cell, 页码：606-617 , 文章类型： Article，,卷期：2010年7-5]
- Mdm2 is an E3 ubiquitin ligase that targets p53 for degradation. p53(515C) (encoding p53R172P) is a hypomorphic allele of p53 that rescues the embryonic lethality of Mdm2(-/-) mice. Mdin2(-/-) p53(515C/515C) mice, howeve...
- Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA
[作者：Warren, L; Manos, PD; Ahfeldt, T; Loh, YH; Li, H; Lau, F; Ebina, W; Mandal, PK; Smith, ZD; Meissner, A; Daley, GQ; Brack, AS; Collins, JJ; Cowan, C; Schlaeger, TM; Rossi, DJ,期刊：Cell Stem Cell, 页码：618-630 , 文章类型： Article，,卷期：2010年7-5]
- Clinical application of induced pluripotent stem cells (iPSCs) is limited by the low efficiency of iPSC derivation and the fact that most protocols modify the genome to effect cellular reprogramming. Moreover, safe and e...
- Friedreich's Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA.TTC Triplet Repeat Instability
[作者：Ku, S; Soragni, E; Campau, E; Thomas, EA; Altun, G; Laurent, LC; Loring, JF; Napierala, M; Gottesfeld, JM,期刊：Cell Stem Cell, 页码：631-637 , 文章类型： Article，,卷期：2010年7-5]
- The inherited neurodegenerative disease Friedreich's ataxia (FRDA) is caused by GAA.TTC triplet repeat hyperexpansions within the first intron of the FXN gene, encoding the mitochondrial protein frataxin. Long GAA.TTC re...
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