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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   A Murine ESC-like State Facilitates Transgenesis and Homologous Recombination in Human Pluripotent Stem Cells [作者：Buecker, C; Chen, HH; Polo, JM; Daheron, L; Bu, L; Barakat, TS; Okwieka, P; Porter, A; Gribnau, J; Hochedlinger, K; Geijsen, N,期刊：Cell Stem Cell, 页码：535-546 , 文章类型： Article，,卷期：2010年6-6] Murine pluripotent stem cells can exist in two functionally distinct states, LIF-dependent embryonic stem cells (ESCs) and bFGF-dependent epiblast stem cells (EpiSCs). However, human pluripotent cells so far seemed to... ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency [作者：Pereira, CF; Piccolo, FM; Tsubouchi, T; Sauer, S; Ryan, NK; Bruno, L; Landeira, D; Santos, J; Banito, A; Gil, J; Koseki, H; Merkenschlager, M; Fisher, AG,期刊：Cell Stem Cell, 页码：547-556 , 文章类型： Article，,卷期：2010年6-6] Embryonic stem cells (ESCs) are pluripotent, self-renewing, and have the ability to reprogram differentiated cell types to pluripotency upon cellular fusion. Polycomb-group (PcG) proteins are important for restraining th... Epigenetic Regulation of Stem Cell Maintenance in the Drosophila Testis via the Nucleosome-Remodeling Factor NURF [作者：Cherry, CM; Matunis, EL,期刊：Cell Stem Cell, 页码：557-567 , 文章类型： Article，,卷期：2010年6-6] Regulation of stem cells depends on both tissue-specific transcriptional regulators and changes in chromatin organization, yet the coordination of these events in endogenous niches is poorly understood. In the Drosophila... Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture [作者：Zeng, YA; Nusse, R,期刊：Cell Stem Cell, 页码：568-577 , 文章类型： Article，,卷期：2010年6-6] Adult stem cells have the ability to self-renew and to generate specialized cells. Self-renewal is dependent on extrinsic niche factors but few of those signals have been identified. In addition, stem cells tend to diffe... CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination [作者：Zawadzka, M; Rivers, LE; Fancy, SPJ; Zhao, C; Tripathi, R; Jamen, F; Young, K; Goncharevich, A; Pohl, H; Rizzi, M; Rowitch, DH; Kessaris, N; Suter, U; Richardson, WD; Franklin, RJM,期刊：Cell Stem Cell, 页码：578-590 , 文章类型： Article，,卷期：2010年6-6] After central nervous system (CNS) demyelination such as occurs during multiple sclerosis there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by Schwann cells. The origins of th... Wilms Tumor Chromatin Profiles Highlight Stem Cell Properties and a Renal Developmental Network [作者：Aiden, AP; Rivera, MN; Rheinbay, E; Ku, MC; Coffman, EJ; Truong, TT; Vargas, SO; Lander, ES; Haber, DA; Bernstein, BE,期刊：Cell Stem Cell, 页码：591-602 , 文章类型： Article，,卷期：2010年6-6] Wilms tumor is the most common pediatric kidney cancer. To identify transcriptional and epigenetic mechanisms that drive this disease, we compared genome-wide chromatin profiles of Wilms tumors, embryonic stem cells (ESC... A Subpopulation of CD26(+) Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer [作者：Pang, R; Law, WL; Chu, ACY; Poon, JT; Lam, CSC; Chow, AKM; Ng, L; Cheung, LWH; Lan, XR; Lan, HY; Tan, VPY; Yau, TC; Poon, RT; Wong, BCY,期刊：Cell Stem Cell, 页码：603-615 , 文章类型： Article，,卷期：2010年6-6] Recent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is responsible for tumor growth in colorectal cancer. However, the role of CSCs in colorectal cancer metastasis is unclear. Here, w... Stepping Stones on Solid Ground [作者：Sweet, DJ,期刊：Cell Stem Cell, 页码：493-493 , 文章类型： Editorial Material，,卷期：2010年6-6] Wnts as Self-Renewal Factors: Mammary Stem Cells and Beyond [作者：Verheyen, EM; Clevers, H,期刊：Cell Stem Cell, 页码：494-495 , 文章类型： Editorial Material，,卷期：2010年6-6] Adult stem cells hold great promise for regenerative medicine, yet it is difficult to expand such cells. In this issue of Cell Stem Cell, Zeng and Nusse (2010) demonstrate that Wnt3A keeps mammary stem cells multipotent ... The Silence of the LADs: Dynamic Genome-Lamina Interactions during ESC Differentiation [作者：Melcer, S; Meshorer, E,期刊：Cell Stem Cell, 页码：495-497 , 文章类型： Editorial Material，,卷期：2010年6-6] In a recent issue of Molecular Cell, Peric-Hupkes et al. (2010) use DamID to map the interactions between chromatin and the nuclear lamina (NL) in differentiating embryonic stem cells. NL-mediated locking/unlocking of ge... Multiple, Interconvertible States of Human Pluripotent Stem Cells [作者：Kerr, CL; Cheng, LZ,期刊：Cell Stem Cell, 页码：497-499 , 文章类型： Editorial Material，,卷期：2010年6-6] Three recent studies, including Buecker et al. (2010), in this issue of Cell Stem Cell, report that human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can exist in distinct but interconvertible ... The Life of a Cell: Probing the Complex Relationships with the World [作者：Deans, TL; Elisseeff, JH,期刊：Cell Stem Cell, 页码：499-501 , 文章类型： Editorial Material，,卷期：2010年6-6] Stem cells live within a complex environment containing an array of signals that impact cell fate. Recently in Nature Materials, Huebsch et. al. (2010) probed the role of mechanical properties on stem cell integrin bindi... Metastatic Cancer Stem Cells: An Opportunity for Improving Cancer Treatment? [作者：Diehn, M; Majeti, R,期刊：Cell Stem Cell, 页码：502-503 , 文章类型： Editorial Material，,卷期：2010年6-6] Many human cancers are driven by cancer stem cells (CSCs) whose connection to metastatic spread remains incompletely understood. In this issue of Cell Stem Cell, Pang et al. (2010) isolate a subpopulation of human colore... Brave Pioneers or Clinical Cowboys? [作者：Davison, AC,期刊：Cell Stem Cell, 页码：504-505 , 文章类型： Editorial Material，,卷期：2010年6-6] Clinical Translation of Stem Cell Therapies: A Bridgeable Gap [作者：Cuende, N; Izeta, A,期刊：Cell Stem Cell, 页码：508-512 , 文章类型： Editorial Material，,卷期：2010年6-6] Stem cell scientists trying to reach patients often lack the multidisciplinary skills needed to overcome complex regulatory barriers and may feel deterred from pursuing clinical implementation. In order to help bridge th... Developing a Case Study Model for Successful Translation of Stem Cell Therapies [作者：Trounson, A; Baum, E; Gibbons, D; Tekamp-Olson, P,期刊：Cell Stem Cell, 页码：513-516 , 文章类型： Editorial Material，,卷期：2010年6-6] Cell therapies derived from pluripotent stem cells are entering the preclinical and early clinical development phase, but eventual translation faces many challenges. We describe a new approach by California to form globa...