- Severe Pediatric Ulcerative Colitis: A Prospective Multicenter Study of Outcomes and Predictors of Response
[作者:Turner, D; Mack, D; Leleiko, N; Walters, TD; Uusoue, K; Leach, ST; Day, AS; Crandall, W; Silverberg, MS; Markowitz, J; Otley, AR; Keljo, D; Mamula, P; Kugathasan, S; Hyams, J; Griffiths, AM,期刊:Gastroenterology, 页码:2282-2291 , 文章类型: Article,,卷期:2010年138-7]
- BACKGROUND & AIMS: In a prospective study of children with severe ulcerative colitis (UC), we aimed to assess outcomes and to identify predictors of nonresponse to intravenous corticosteroids. METHODS: A total of 128 chi...
- One to 2-Year Surveillance Intervals Reduce Risk of Colorectal Cancer in Families With Lynch Syndrome
[作者:Vasen, HFA; Abdirahman, M; Brohet, R; Langers, AMJ; Kleibeuker, JH; van Kouwen, M; Koornstra, JJ; Boot, H; Cats, A; Dekker, E; Sanduleanu, S; Poley, JW; Hardwick, JCH; Cappel, WHDT; van der Meulen-de Jong,AE; Tan, TG; Jacobs, MAJM; Mohamed, FLA; de Boer, SY; van de Meeberg, PC; Verhulst, ML; Salemans, JM; Van Bentem, N; Westerveld, BD; Vecht, J; Nagengast, FM,期刊:Gastroenterology, 页码:2300-2306 , 文章类型: Article,,卷期:2010年138-7]
- BACKGROUND & AIMS: Two percent to 4% of all cases of colorectal cancer (CRC) are associated with Lynch syndrome. Dominant clustering of CRC (non-Lynch syndrome) accounts for 1%-3% of the cases. Because carcinogenesis is ...
- Replicated Association Between an IL28B Gene Variant and a Sustained Response to Pegylated Interferon and Ribavirin
[作者:McCarthy, JJ; Li, JH; Thompson, A; Suchindran, S; Lao, XQ; Patel, K; Tillmann, HL; Muir, AJ; McHutchison, JG,期刊:Gastroenterology, 页码:2307-2314 , 文章类型: Article,,卷期:2010年138-7]
- BACKGROUND & AIMS: Patients with chronic hepatitis C virus (HCV) infections are treated with pegylated interferon and ribavirin (PEG-IFN/RBV), which is effective in less than 50% of those infected with HCV genotype 1. Ge...
- Early Laparoscopic Cholecystectomy Improves Outcomes After Endoscopic Sphincterotomy for Choledochocystolithiasis
[作者:Reinders, JSK; Goud, A; Timmer, R; Kruijt, PM; Witteman, BJM; Smakman, N; Breumelhof, R; Donkervoort, SC; Jansen, JM; Heisterkamp, J; Grobben, M; van Ramshorst, B; Boerma, D,期刊:Gastroenterology, 页码:2315-2320 , 文章类型: Article,,卷期:2010年138-7]
- BACKGROUND & AIMS: Patients with choledochocystolithiasis generally undergo endoscopic sphincterotomy (ES) followed by laparoscopic cholecystectomy (LC). However, many patients receive this surgery 6-8 weeks after ES. Th...
- Factors That Determine the Development and Progression of Gastroesophageal Varices in Patients With Chronic Hepatitis C
[作者:Fontana, RJ; Sanyal, AJ; Ghany, MG; Lee, WM; Reid, AE; Naishadham, D; Everson, GT; Kahn, JA; Di Bisceglie, AM; Szabo, G; Morgan, TR; Everhart, JE,期刊:Gastroenterology, 页码:2321-U176 , 文章类型: Article,,卷期:2010年138-7]
- BACKGROUND & AIMS: We aimed to identify the incidence and predictors of de novo gastroesophageal variceal formation and progression in a large cohort of patients with chronic hepatitis C and advanced fibrosis. METHODS: A...
- Persistence of Cognitive Impairment After Resolution of Overt Hepatic Encephalopathy
[作者:Bajaj, JS; Schubert, CM; Heuman, DM; Wade, JB; Gibson, DP; Topaz, A; Saeian, K; Hafeezullah, M; Bell, DE; Sterling, RK; Stravitz, RT; Luketic, V; White, MB; Sanyal, AJ,期刊:Gastroenterology, 页码:2332-2340 , 文章类型: Article,,卷期:2010年138-7]
- BACKGROUND & AIMS: In patients with cirrhosis, hepatic encephalopathy (HE) has acute but reversible as well as chronic components. We investigated the extent of residual cognitive impairment following clinical resolution...
- Donor Race Does Not Predict Graft Failure After Liver Transplantation
[作者:Asrani, SK; Lim, YS; Therneau, TM; Pedersen, RA; Heimbach, J; Kim, WR,期刊:Gastroenterology, 页码:2341-2347 , 文章类型: Article,,卷期:2010年138-7]
- BACKGROUND & AIMS: Donor race has been proposed to predict graft failure after liver transplantation. We evaluated the extent to which the center where the transplantation surgery was performed and other potential confou...
- Low Bone Mass and Severity of Cholestasis Affect Fracture Risk in Patients With Primary Biliary Cirrhosis
[作者:Guanabens, N; Cerda, D; Monegal, A; Pons, F; Caballeria, L; Peris, P; Pares, A,期刊:Gastroenterology, 页码:2348-2356 , 文章类型: Article,,卷期:2010年138-7]
- BACKGROUND & AIMS: The influence of osteoporosis and liver disease on fracture risk is not well characterized in patients with primary biliary cirrhosis (PBC). We studied a large series of women with PBC to assess the pr...
- Oncogenic K-Ras Turns Death Receptors Into Metastasis-Promoting Receptors in Human and Mouse Colorectal Cancer Cells
[作者:Hoogwater, FJH; Nijkamp, MW; Smakman, N; Steller, EJA; Emmink, BL; Westendorp, BF; Raats, DAE; Sprick, MR; Schaefer, U; Van Houdt, WJ; De Bruijn, MT; Schackmann, RCJ; Derksen, PWB; Medema, JP; Walczak, H; Rinkes, IHMB; Kranenburg, O,期刊:Gastroenterology, 页码:2357-2367 , 文章类型: Article,,卷期:2010年138-7]
- BACKGROUND & AIMS: Death receptors expressed on tumor cells can prevent metastasis formation by inducing apoptosis, but they also can promote migration and invasion. The determinants of death receptor signaling output ar...
- Hedgehog Is an Anti-Inflammatory Epithelial Signal for the Intestinal Lamina Propria
[作者:Zacharias, WJ; Li, X; Madison, BB; Kretovich, K; Kao, JY; Merchant, JL; Gumucio, DL,期刊:Gastroenterology, 页码:2368-U226 , 文章类型: Article,,卷期:2010年138-7]
- BACKGROUND & AIMS: Epithelial Hedgehog (Hh) ligands regulate several aspects of fetal intestinal organogenesis, and emerging data implicate the Hh pathway in inflammatory signaling in the adult colon. Here, we investigat...
- Mutations in TTC37 Cause Trichohepatoenteric Syndrome (Phenotypic Diarrhea of Infancy)
[作者:Hartley, JL; Zachos, NC; Dawood, B; Donowitz, M; Forman, J; Pollitt, RJ; Morgan, NV; Tee, L; Gissen, P; Kahr, WHA; Knisely, AS; Watson, S; Chitayat, D; Booth, IW; Protheroe, S; Murphy, S; De Vries, E; Kelly, DA; Maher, ER,期刊:Gastroenterology, 页码:2388-U249 , 文章类型: Article,,卷期:2010年138-7]
- BACKGROUND & AIMS: Trichohepatoenteric syndrome (THES) is an autosomal-recessive disorder characterized by life-threatening diarrhea in infancy, immunodeficiency, liver disease, trichorrhexis nodosa, facial dysmorphism, ...
- CD206-Positive M2 Macrophages That Express Heme Oxygenase-1 Protect Against Diabetic Gastroparesis in Mice
[作者:Choi, KM; Kashyap, PC; Dutta, N; Stoltz, GJ; Ordog, T; Donohue, TS; Bauer, AJ; Linden, DR; Szurszewski, JH; Gibbons, SJ; Farrugia, G,期刊:Gastroenterology, 页码:2399-U261 , 文章类型: Article,,卷期:2010年138-7]
- BACKGROUND & AIMS: Gastroparesis is a well-recognized complication of diabetes. In diabetics, up-regulation of heme oxygenase-1 (HO1) in gastric macrophages protects against oxidative stress-induced damage. Loss of up-re...
- Rotavirus Infection of Murine Small Intestine Causes Colonic Secretion via Age Restricted Galanin-1 Receptor Expression
[作者:Hempson, SJ; Matkowskyj, K; Bansal, A; Tsao, E; Habib, I; Benya, R; Mackow, ER; Shaw, RD,期刊:Gastroenterology, 页码:2410-2417 , 文章类型: Article,,卷期:2010年138-7]
- BACKGROUND & AIMS: Mechanisms for age restriction of rotavirus diarrhea are unclear. Because rotavirus primarily infects small intestine, colonic contribution has not been widely studied. Recent data suggest that colonic...
- Riluzole Normalizes Early-Life Stress-Induced Visceral Hypersensitivity in Rats: Role of Spinal Glutamate Reuptake Mechanisms
[作者:Gosselin, RD; O'Connor, RM; Tramullas, M; Julio-Pieper, M; Dinan, TG; Cryan, JF,期刊:Gastroenterology, 页码:2418-2425 , 文章类型: Article,,卷期:2010年138-7]
- BACKGROUND & AIMS: The molecular basis underlying visceral hypersensitivity in functional irritable bowel syndrome remains elusive, resulting in poor treatment effectiveness. Because alterations in spinal non-neuronal (a...
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