- The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes
[作者:Bostrom, P; Andersson, L; Vind, B; Haversen, L; Rutberg, M; Wickstrom, Y; Larsson, E; Jansson, PA; Svensson, MK; Branemark, R; Ling, C; Beck-Nielsen, H; Boren, J; Hojlund, K; Olofsson, SO,期刊:Diabetes, 页码:1870-1878 , 文章类型: Article,,卷期:2010年59-8]
- OBJECTIVE-Our previous studies suggest that the SNARE protein synaptosomal-associated protein of 23 kDa (SNAP23) is involved in the link between increased lipid levels and insulin resistance in cardiomyocytes. The object...
- Atrogin-1 Affects Muscle Protein Synthesis and Degradation When Energy Metabolism Is Impaired by the Antidiabetes Drug Berberine
[作者:Wang, HL; Liu, DJ; Cao, PR; Lecker, S; Hu, ZY,期刊:Diabetes, 页码:1879-1889 , 文章类型: Article,,卷期:2010年59-8]
- OBJECTIVE-Defects in insulin/IGF-1 signaling stimulate muscle protein loss by suppressing protein synthesis and increasing protein degradation. Since an herbal compound, berberine, lowers blood levels of glucose and lipi...
- Leptin Directly Depolarizes Preproglucagon Neurons in the Nucleus Tractus Solitarius Electrical Properties of Glucagon-Like Peptide 1 Neurons
[作者:Hisadome, K; Reimann, F; Gribble, FM; Trapp, S,期刊:Diabetes, 页码:1890-1898 , 文章类型: Article,,卷期:2010年59-8]
- OBJECTIVE-Glucagon-like peptide (GLP)-1 inhibits food intake, acting both in the periphery and within the central nervous system. It is unclear if gut-derived GLP-1 can enter the brain, or whether GLP-1 from preproglucag...
- Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women
[作者:Kars, M; Yang, L; Gregor, MF; Mohammed, BS; Pietka, TA; Finck, BN; Patterson, BW; Horton, JD; Mittendorfer, B; Hotamisligil, GS; Klein, S,期刊:Diabetes, 页码:1899-1905 , 文章类型: Article,,卷期:2010年59-8]
- OBJECTIVE-Insulin resistance is commonly associated with obesity. Studies conducted in obese mouse models found that endoplasmic reticulum (ER) stress contributes to insulin resistance, and treatment with tauroursodeoxyc...
- T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis
[作者:Fukushima, A; Loh, K; Galic, S; Fam, B; Shields, B; Wiede, F; Tremblay, ML; Watt, MJ; Andrikopoulos, S; Tiganis, T,期刊:Diabetes, 页码:1906-1914 , 文章类型: Article,,卷期:2010年59-8]
- OBJECTIVE-Insulin-induced phosphatidylinositol 3-kinase (PI3K)/Akt signaling and interleukin-6 (IL-6)-instigated JAK/STAT3-signaling pathways in the liver inhibit the expression of gluconeogenic genes to decrease hepatic...
- Modulation of Notch-1 Signaling Alleviates Vascular Endothelial Growth Factor-Mediated Diabetic Nephropathy
[作者:Lin, CL; Wang, FS; Hsu, YC; Chen, CN; Tseng, MJ; Saleem, MA; Chang, PJ; Wang, JY,期刊:Diabetes, 页码:1915-1925 , 文章类型: Article,,卷期:2010年59-8]
- OBJECTIVE-Disturbances in podocytes are typically associated with marked proteinuria, a hallmark of diabetic nephropathy. This study was conducted to investigate modulation of Notch-1 signaling in high glucose (HG)-stres...
- Induction of Human beta-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6
[作者:Fiaschi-Taesch, NM; Salim, F; Kleinberger, J; Troxell, R; Cozar-Castellano, I; Selk, K; Cherok, E; Takane, KK; Scott, DK; Stewart, AF,期刊:Diabetes, 页码:1926-1936 , 文章类型: Article,,卷期:2010年59-8]
- OBJECTIVE-Most knowledge on human beta-cell cycle control derives from immunoblots of whole human islets, mixtures of beta-cells and non-beta-cells. We explored the presence, subcellular localization, and function of fiv...
- Mesenchymal Bone Morphogenetic Protein Signaling Is Required for Normal Pancreas Development
[作者:Ahnfelt-Ronne, J; Ravassard, P; Pardanaud-Glavieux, C; Scharfmann, R; Serup, P,期刊:Diabetes, 页码:1948-1956 , 文章类型: Article,,卷期:2010年59-8]
- OBJECTIVE-Pancreas organogenesis is orchestrated by interactions between the epithelium and the mesenchyme, but these interactions are not completely understood. Here we investigated a role for bone morphogenetic protein...
- Increased beta-cell Mass by Islet Transplantation and PLAG1 Overexpression Causes Hyperinsulinemic Normoglycemia and Hepatic Insulin Resistance in Mice
[作者:Declercq, J; Kumar, A; Van Diepen, JA; Vroegrijk, IOCM; Gysemans, C; Di Pietro, C; Voshol, PJ; Mathieu, C; Ectors, N; Van de Ven, WJM; Verfaillie, CM,期刊:Diabetes, 页码:1957-1965 , 文章类型: Article,,卷期:2010年59-8]
- OBJECTIVE-It is believed that an organism remains normoglycemic despite an increase in the beta-cell mass because of decreased insulin production by beta-cells on a per-cell basis However, some transgenic mouse models wi...
- Deficiency in B7-H1 (PD-L1)/PD-1 Coinhibition Triggers Pancreatic beta-Cell Destruction by Insulin-Specific, Murine CD8 T-Cells
[作者:Rajasalu, T; Brosi, H; Schuster, C; Spyrantis, A; Boehm, BO; Chen, LP; Reimann, J; Schirmbeck, R,期刊:Diabetes, 页码:1966-1973 , 文章类型: Article,,卷期:2010年59-8]
- OBJECTIVE-RIP-B7.1 mice expressing the costimulator molecule B7 1 (CD80) on pancreatic beta-cells are a well established model to characterize preproinsulin-specific CD8 T-cell responses and experimental autoimmune diabe...
- Decreased Circulating Progenitor Cell Number and Failed Mechanisms of Stromal Cell-Derived Factor-1 alpha Mediated Bone Marrow Mobilization Impair Diabetic Tissue Repair
[作者:Tepper, OM; Carr, J; Allen, RJ; Chang, CC; Lin, CD; Tanaka, R; Gupta, SM; Levine, JP; Saadeh, PB; Warren, SM,期刊:Diabetes, 页码:1974-1983 , 文章类型: Article,,卷期:2010年59-8]
- OBJECTIVE-Progenitor cells (PCs) contribute to postnatal neovascularization and tissue repair. Here, we explore the mechanism contributing to decreased diabetic circulating PC number and propose a novel treatment to rest...
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