- G-protein-coupled receptor GPR21 knockout mice display improved glucose tolerance and increased insulin response
[作者:Gardner, J; Wu, S; Ling, L; Danao, J; Li, Y; Yeh, WC; Tian, H; Baribault, H,期刊:Biochemical and Biophysical Research Communications, 页码:1-5 , 文章类型: Article,,卷期:2012年418-1]
- GPR21 is an orphan G-protein-coupled receptor. We found that mice deficient for the GPR21 gene were resistant to diet-induced obesity. Knockout mice were leaner than their wildtype counterpart, despite that no difference...
- CRKL plays a pivotal role in tumorigenesis of head and neck squamous cell carcinoma through the regulation of cell adhesion
[作者:Yanagi, H; Wang, L; Nishihara, H; Kimura, T; Tanino, M; Yanagi, T; Fukuda, S; Tanaka, S,期刊:Biochemical and Biophysical Research Communications, 页码:104-109 , 文章类型: Article,,卷期:2012年418-1]
- The signaling adapter protein CRK is an indispensable molecule involved in regulating the malignant potential of human cancers. CRK-like (CRKL) is a hematopoietic cell-dominant homologue of CRK that is reported to be pho...
- Augmented glutathione synthesis decreases acrolein toxicity
[作者:Tomitori, H; Nakamura, M; Sakamoto, A; Terui, Y; Yoshida, M; Igarashi, K; Kashiwagi, K,期刊:Biochemical and Biophysical Research Communications, 页码:110-115 , 文章类型: Article,,卷期:2012年418-1]
- We have shown recently that acrolein is more strongly involved in cell damage than reactive oxygen species during brain infarction. Thus, we tried to isolate cells with reduced susceptibility to acrolein toxicity to clar...
- ErbB4 localization to cardiac myocyte nuclei, and its role in myocyte DNA damage response
[作者:Icli, B; Bharti, A; Pentassuglia, L; Peng, XY; Sawyer, DB,期刊:Biochemical and Biophysical Research Communications, 页码:116-121 , 文章类型: Article,,卷期:2012年418-1]
- The intracellular domain of ErbB4 receptor tyrosine kinase is known to translocate to the nucleus of cells where it can regulate p53 transcriptional activity. The purpose of this study was to examine whether ErbB4 can lo...
- Modulation of matrix mineralization by Vwc2-like protein and its novel splicing isoforms
[作者:Ohyama, Y; Katafuchi, M; Almehmadi, A; Venkitapathi, S; Jaha, H; Ehrenman, J; Morcos, J; Aljamaan, R; Mochida, Y,期刊:Biochemical and Biophysical Research Communications, 页码:12-16 , 文章类型: Article,,卷期:2012年418-1]
- In search of new cysteine knot protein (CKP) family members, we found a novel gene called von Willebrand factor C domain-containing protein 2-like (Vwc2l, also known as Brorin-like) and its transcript variants (Vwc2l-1, ...
- Crystal structures of the Arabidopsis thaliana abscisic acid receptor PYL10 and its complex with abscisic acid
[作者:Sun, DM; Wang, HP; Wu, MH; Zang, JY; Wu, FM; Tian, CL,期刊:Biochemical and Biophysical Research Communications, 页码:122-127 , 文章类型: Article,,卷期:2012年418-1]
- Abscisic acid (ABA) is one of the most essential phytohormones, and plays an important role in growth and development regulation, as well as in stress responses. The PYR/PYL/RCAR family (PYL for short)- comprised of 14 p...
- Evaluation of calcium depletion as a strategy for enhancement of mucosal absorption of macromolecules
[作者:Vllasaliu, D; Shubber, S; Garnett, M; Alexander, C; Eaton, M; Stolnik, S,期刊:Biochemical and Biophysical Research Communications, 页码:128-133 , 文章类型: Article,,卷期:2012年418-1]
- Extracellular calcium is crucial for functioning of the epithelial barrier. Compounds that bind calcium, reducing its extracellular levels, have therefore been investigated as mucosal absorption enhancers. However, the c...
- FAM5C is a soluble osteoblast differentiation factor linking muscle to bone
[作者:Tanaka, K; Matsumoto, E; Higashimaki, Y; Sugimoto, T; Seino, S; Kaji, H,期刊:Biochemical and Biophysical Research Communications, 页码:134-139 , 文章类型: Article,,卷期:2012年418-1]
- Muscle mass is related to higher bone mass and a reduction in fracture risk. However, the interactions between muscle tissues and bone metabolism are incompletely understood and there might be some humoral factors that a...
- Molecular interaction of the first 3 enzymes of the de novo pyrimidine biosynthetic pathway of Trypanosoma cruzi
[作者:Nara, T; Hashimoto, M; Hirawake, H; Liao, CW; Fukai, Y; Suzuki, S; Tsubouchi, A; Morales, J; Takamiya, S; Fujimura, T; Taka, H; Mineki, R; Fan, CK; Inaoka, DK; Inoue, M; Tanaka, A; Harada, S; Kita, K; Aoki, T,期刊:Biochemical and Biophysical Research Communications, 页码:140-143 , 文章类型: Article,,卷期:2012年418-1]
- The first 3 reaction steps of the de novo pyrimidine biosynthetic pathway are catalyzed by carbamoylphosphate synthetase II (CPSII), aspartate transcarbamoylase (ATC), and dihydroorotase (DHO), respectively. In eukaryote...
- Extracellular acidosis accelerates bone resorption by enhancing osteoclast survival, adhesion, and migration
[作者:Ahn, H; Kim, JM; Lee, K; Kim, H; Jeong, D,期刊:Biochemical and Biophysical Research Communications, 页码:144-148 , 文章类型: Article,,卷期:2012年418-1]
- Acidic extracellular pH promotes osteoporotic bone loss by osteoclast activation. However, the change of osteoclastic cell behavior in acidosis-stimulated bone resorption process is unknown. We found that lowering extrac...
- Formation of tRNA granules in the nucleus of heat-induced human cells
[作者:Miyagawa, R; Mizuno, R; Watanabe, K; Ijiri, K,期刊:Biochemical and Biophysical Research Communications, 页码:149-155 , 文章类型: Article,,卷期:2012年418-1]
- The stress response, which can trigger various physiological phenomena, is important for living organisms. For instance, a number of stress-induced granules such as P-body and stress granule have been identified. These g...
- Superiority of PLK-2 as alpha-synuclein phosphorylating agent relies on unique specificity determinants
[作者:Salvi, M; Trashi, E; Marin, O; Negro, A; Sarno, S; Pinna, LA,期刊:Biochemical and Biophysical Research Communications, 页码:156-160 , 文章类型: Article,,卷期:2012年418-1]
- Phosphorylation of alpha-synuclein at Set-129 is of crucial relevance to Parkinson's disease and related synucleinopathies. Here we provide biochemical evidence that PLK2 and to a lesser extent PLK3 are superior over CK2...
- Increase of L-type Ca2+ current by protease-activated receptor 2 activation contributes to augmentation of spontaneous uterine contractility in pregnant rats
[作者:Kim, YH; Chung, S; Lee, YH; Kim, EC; Ahn, DS,期刊:Biochemical and Biophysical Research Communications, 页码:167-172 , 文章类型: Article,,卷期:2012年418-1]
- We evaluated the effects of protease-activated receptor (PAR)-2 on spontaneous myometrial contraction (SMC) in isolated term pregnant myometrial strips of rat, and elucidated the cellular mechanisms of this effect using ...
- CCL3 induced migration occurs independently of intracellular calcium release
[作者:Cardaba, CM; Jacques, RO; Barrett, JE; Hassell, KM; Kavanagh, A; Remington, FC; Tse, T; Mueller, A,期刊:Biochemical and Biophysical Research Communications, 页码:17-21 , 文章类型: Article,,卷期:2012年418-1]
- The molecular signalling pathway of cell migration and whether it can occur independently of the release of intracellular calcium is still not completely understood. Therefore we investigated here the molecular mechanism...
- Inhibition of Notch signaling by Dll4-Fc promotes reperfusion of acutely ischemic tissues
[作者:Liu, R; Trindade, A; Sun, ZF; Kumar, R; Weaver, FA; Krasnoperov, V; Naga, K; Duarte, A; Gill, PS,期刊:Biochemical and Biophysical Research Communications, 页码:173-179 , 文章类型: Article,,卷期:2012年418-1]
- Notch pathway regulates vessel development and maturation. Dll4, a high-affinity ligand for Notch, is expressed predominantly in the arterial endothelium and is induced by hypoxia among other factors. Inhibition of Dll4 ...
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