- Distinct spatio-temporal Ca2+ signaling elicited by integrin alpha 2 beta 1 and glycoprotein VI under flow
[作者:Mazzucato, M; Cozzi, MR; Battiston, M; Jandrot-Perrus, M; Mongiat, M; Marchese, P; Kunicki, TJ; Ruggeri, ZM; De Marco, L,期刊:Blood, 页码:2793-2801 , 文章类型: Article,,卷期:2009年114-13]
- We studied how integrin alpha 2 beta 1 and glycoprotein VI (GPVI) contribute to collagen-induced platelet activation under flow conditions by evaluating stable adhesion and intracellular Ca2+ concentration ([Ca2+](i)) of...
- Enhanced efficacy of recombinant FVIII in noncovalent complex with PEGylated liposome in hemophilia A mice
[作者:Pan, JL; Liu, TY; Kim, JY; Zhu, DG; Patel, C; Cui, ZH; Zhang, X; Newgren, JO; Reames, A; Canivel, D; Jesmok, G; Pierce, GF; Sommer, JM; Jiang, HY,期刊:Blood, 页码:2802-2811 , 文章类型: Article,,卷期:2009年114-13]
- Recombinant FVIII formulated in PEGylated liposomes (rFVIII-PEG-Lip) was reported to increase the bleed-free days from 7 to 13 days (at 35 IU/kg rFVIII) in severe hemophilia A patients. To understand the underlying mecha...
- Thrombin induces the expression of oncostatin M via AP-1 activation in human macrophages: a link between coagulation and inflammation
[作者:Kastl, SP; Speidl, WS; Katsaros, KM; Kaun, C; Rega, G; Assadian, A; Hagmueller, GW; Hoeth, M; de Martin, R; Ma, YS; Maurer, G; Huber, K; Wojta, J,期刊:Blood, 页码:2812-2818 , 文章类型: Article,,卷期:2009年114-13]
- Macrophages as inflammatory cells are involved in the pathogenesis of atherosclerosis that today is recognized as an inflammatory disease. Activation of coagulation leads to the late complication of atherosclerosis, name...
- A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF
[作者:Zanardelli, S; Chion, ACK; Groot, E; Lenting, PJ; McKinnon, TAJ; Laffan, MA; Tseng, M; Lane, DA,期刊:Blood, 页码:2819-2828 , 文章类型: Article,,卷期:2009年114-13]
- ADAMTS13 metalloprotease regulates the multimeric size of von Willebrand factor (VWF) by cleaving the Tyr1605-Met1606 bond in the VWF A2 domain. The mechanisms of VWF recognition by ADAMTS13 have yet to be fully resolved...
- Selective depletion of alloreactive T cells by targeted therapy of heat shock protein 90: a novel strategy for control of graft-versus-host disease
[作者:Stuehler, C; Mielke, S; Chatterjee, M; Duell, J; Lurati, S; Rueckert, F; Einsele, H; Bargou, RC; Topp, MS,期刊:Blood, 页码:2829-2836 , 文章类型: Article,,卷期:2009年114-13]
- Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in patients with hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation. Current treatment of GVHD relies on im...
- Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome
[作者:Roumenina, LT; Jablonski, M; Hue, C; Blouin, J; Dimitrov, JD; Dragon-Durey, MA; Cayla, M; Fridman, WH; Macher, MA; Ribes, D; Moulonguet, L; Rostaing, L; Satchell, SC; Mathieson, PW; Sautes-Fridman, C; Loirat, C; Regnier, CH; Halbwachs-Mecarelli, L; Fremeaux-Bacchi, V,期刊:Blood, 页码:2837-2845 , 文章类型: Article,,卷期:2009年114-13]
- Complement is a major innate immune defense against pathogens, tightly regulated to prevent host tissue damage. Atypical hemolytic uremic syndrome (aHUS) is characterized by endothelial damage leading to renal failure an...
- Role of TNFRSF13B variants in patients with common variable immunodeficiency
[作者:Martinez-Pomar, N; Detkova, D; Arostegui, JI; Alvarez, A; Soler-Palacin, P; Vidaller, A; Espanol, T; Sampalo, A; de Gracia, J; Hernandez, M; Yague, J; Matamoros, N,期刊:Blood, 页码:2846-2848 , 文章类型: Letter,,卷期:2009年114-13]
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- Identification of monoclonal B-cell lymphocytosis among sibling transplant donors for chronic lymphocytic leukemia patients
[作者:Del Giudice, I; Mauro, FR; De Propris, MS; Della Starza, I; Armiento, D; Iori, AP; Torelli, GF; Guarini, A; Foa, R,期刊:Blood, 页码:2848-2849 , 文章类型: Letter,,卷期:2009年114-13]
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