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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共39条记录   Role of leukemia cell invadosome in extramedullary infiltration [作者：Stefanidakis, M; Karjalainen, K; Jaalouk, DE; Gahmberg, CG; O'Brien, S; Pasqualini, R; Arap, W; Koivunen, E,期刊：Blood, 页码：3008-3017 , 文章类型： Article，,卷期：2009年114-14] Acute myelogenous leukemias (AMLs) are characterized by medullary and extramedullary invasion. We hypothesized that a supramolecular complex, the leukemia-cell invadosome, which contains certain integrins, matrix metallo... In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: a new disease paradigm [作者：Lambert, JR; Everington, T; Linch, DC; Gale, RE,期刊：Blood, 页码：3018-3023 , 文章类型： Article，,卷期：2009年114-14] In essential thrombocythemia (ET), the JAK2-V617F mutation is usually restricted to a subpopulation of neutrophils and platelets, and production of JAK2 wild-type (WT) platelets is not suppressed. Nonmutated precursor ce... AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features [作者：Haferlach, C; Mecucci, C; Schnittger, S; Kohlmann, A; Mancini, M; Cuneo, A; Testoni, N; Rege-Cambrin, G; Santucci, A; Vignetti, M; Fazi, P; Martelli, MP; Haferlach, T; Falini, B,期刊：Blood, 页码：3024-3032 , 文章类型： Article，,卷期：2009年114-14] Acute myeloid leukemia (AML) with mutated NPM1 usually carries normal karyotype (NK), but it may harbor chromosomal aberrations whose significance remains unclear. We addressed this question in 631 AML patients with muta... Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines [作者：Hayashida, K; Parks, WC; Park, PW,期刊：Blood, 页码：3033-3043 , 文章类型： Article，,卷期：2009年114-14] Heparan sulfate binds to and regulates many inflammatory mediators in vitro, suggesting that it serves an important role in directing the progression and outcome of inflammatory responses in vivo. Here, we evaluated the ... Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1 [作者：Skokowa, J; Fobiwe, JP; Dan, L; Thakur, BK; Welte, K,期刊：Blood, 页码：3044-3051 , 文章类型： Article，,卷期：2009年114-14] Severe congenital neutropenia (CN) is a heterogeneous disorder of myelopoiesis which follows an autosomal dominant or autosomal recessive pattern of inheritance. Genetic analyses indicate mutations in the ELA2 gene in mo... Neutrophils express CD52 and exhibit complement-mediated lysis in the presence of alemtuzumab [作者：Ambrose, LR; Morel, AS; Warrens, AN,期刊：Blood, 页码：3052-3055 , 文章类型： Article，,卷期：2009年114-14] Neutropenia is a recognized adverse event in patients treated with the humanized anti-CD52 monoclonal antibody alemtuzumab. However, as it is widely believed that neutrophils do not express CD52, the etiology of alemtuzu... Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion [作者：Chari, R; Kim, S; Murugappan, S; Sanjay, A; Daniel, JL; Kunapuli, SP,期刊：Blood, 页码：3056-3063 , 文章类型： Article，,卷期：2009年114-14] Protein kinase C-delta (PKC-delta) is expressed in platelets and activated downstream of protease-activated receptors (PARs) and glycoprotein VI (GPVI) receptors. We have previously shown that PKC-delta positively regula... Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells [作者：Eberhard, Y; McDermott, SP; Wang, XM; Gronda, M; Venugopal, A; Wood, TE; Hurren, R; Datti, A; Batey, RA; Wrana, J; Antholine, WE; Dick, J; Schimmer, AD,期刊：Blood, 页码：3064-3073 , 文章类型： Article，,卷期：2009年114-14] Off-patent drugs with previously unrecognized anticancer activity could be rapidly repurposed for this new indication. To identify such compounds, we conducted 2 independent cell-based chemical screens and identified the... Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo [作者：Romay-Penabad, Z; Montiel-Manzano, MG; Shilagard, T; Papalardo, E; Vargas, G; Deora, AB; Wang, M; Jacovina, AT; Garcia-Latorre, E; Reyes-Maldonado, E; Hajjar, KA; Pierangeli, SS,期刊：Blood, 页码：3074-3083 , 文章类型： Article，,卷期：2009年114-14] Antiphospholipid (aPL) antibodies recognize receptor-bound beta(2) glycoprotein I (beta(2)GPI) on target cells, and induce an intracellular signaling and a procoagulant/proinflammatory phenotype that leads to thrombosis.... Cell adhesion molecule 1: a novel risk factor for venous thrombosis [作者：Hasstedt, SJ; Bezemer, ID; Callas, PW; Vossen, CY; Trotman, W; Hebbel, RP; Demers, C; Rosendaal, FR; Bovill, EG,期刊：Blood, 页码：3084-3091 , 文章类型： Article，,卷期：2009年114-14] Protein C (PC) deficiency increases the risk of venous thrombosis (VT) among members of Kindred Vermont II but fails to fully account for the inheritance pattern. A genome scan of the pedigree supported the presence of a... Fucosylated chondroitin sulfate inhibits plasma thrombin generation via targeting of the factor IXa heparin-binding exosite [作者：Buyue, Y; Sheehan, JP,期刊：Blood, 页码：3092-3100 , 文章类型： Article，,卷期：2009年114-14] Depolymerized holothurian glycosaminoglycan (DHG) is a fucosylated chondroitin sulfate with antithrombin-independent antithrombotic properties. Heparin cofactor II (HCII)-dependent and -independent mechanisms for DHG inh... Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease [作者：Yi, TS; Chen, Y; Wang, L; Du, G; Huang, D; Zhao, DC; Johnston, H; Young, J; Todorov, I; Umetsu, DT; Chen, LP; Iwakura, Y; Kandeel, F; Forman, S; Zeng, DF,期刊：Blood, 页码：3101-3112 , 文章类型： Article，,卷期：2009年114-14] In acute graft-versus-host disease (GVHD), naive donor CD4(+) T cells recognize alloantigens on host antigen-presenting cells and differentiate into T helper (Th) subsets (Th1, Th2, and Th17 cells), but the role of Th su... Impact of macrophage infiltration of skin lesions on survival after allogeneic stem cell transplantation: a clue to refractory graft-versus-host disease [作者：Nishiwaki, S; Terakura, S; Ito, M; Goto, T; Seto, A; Watanabe, K; Yanagisawa, M; Imahashi, N; Tsukamoto, S; Shimba, M; Ozawa, Y; Miyamura, K,期刊：Blood, 页码：3113-3116 , 文章类型： Article，,卷期：2009年114-14] We retrospectively reviewed 104 biopsy specimens of previously untreated skin acute graft-versus-host disease (GVHD) within 100 days after allogeneic stem cell transplantation, and analyzed the relationship between types... Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production [作者：Choi, YS; Choi, HJ; Min, JK; Pyun, BJ; Maeng, YS; Park, H; Kim, J; Kim, YM; Kwon, YG,期刊：Blood, 页码：3117-3126 , 文章类型： Article，,卷期：2009年114-14] Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is emerging as a new regulator of immune responses and inflammatory vascular diseases. Although IL-33 and its cognate receptor ST2 appear to be expressed in v... Same mutation, different allele [作者：Aichberger, KJ; Fleischman, AG; Deininger, MW,期刊：Blood, 页码：2853-2854 , 文章类型： Editorial Material，,卷期：2009年114-14] High coagulant factors & venous thrombosis [作者：Doggen, CJM,期刊：Blood, 页码：2854-2855 , 文章类型： Editorial Material，,卷期：2009年114-14]