- Early RB94-produced cytotoxicity in cancer cells is independent of caspase activation or 50 kb DNA fragmentation
[作者：Zhou, J; Zhang, XQ; Ashoori, F; McConkey, DJ; Knowles, MA; Dong, L; Benedict, WF,期刊：Cancer gene therapy, 页码：13-19 , 文章类型： Article，,卷期：2009年16-1]
- RB94, which lacks the N-terminal 112 amino-acid residues of the full-length retinoblastoma protein (RB110) is a more potent inhibitor of cancer cell growth than RB110, being cytotoxic to all cancer cell lines studied, in...
- Inhibition of renal cancer cell growth in vitro and in vivo with oncolytic adenovirus armed short hairpin RNA targeting Ki-67 encoding mRNA
[作者：Zheng, JN; Pei, DS; Mao, LJ; Liu, XY; Mei, DD; Zhang, BF; Shi, Z; Wen, RM; Sun, XQ,期刊：Cancer gene therapy, 页码：20-32 , 文章类型： Article，,卷期：2009年16-1]
- RNA interference (RNAi) has been proved to be a powerful tool for gene knockdown purpose and holds great promise for the treatment of cancer. Our previous study demonstrated that the reduction of Ki-67 expression by mean...
- An oncolytic adenovirus expressing granulocyte macrophage colony-stimulating factor shows improved specificity and efficacy for treating human solid tumors
[作者：Lei, N; Shen, FB; Chang, JH; Wang, L; Li, H; Yang, C; Li, J; Yu, DC,期刊：Cancer gene therapy, 页码：33-43 , 文章类型： Article，,卷期：2009年16-1]
- To study the tumor specificity and antitumor activity of the replication-competent oncolytic adenovirus TOA02, which is controlled by a modified human telomerase reverse transcriptase (hTERT) promoter and expresses granu...
- Chimeric form of tumor necrosis factor-alpha has enhanced surface expression and antitumor activity
[作者：Rieger, R; Whitacre, D; Cantwell, MJ; Prussak, C; Kipps, TJ,期刊：Cancer gene therapy, 页码：53-64 , 文章类型： Article，,卷期：2009年16-1]
- Tumor necrosis factor (TNF)-alpha is a type-II transmembrane protein that is cleaved by TNF-alpha-converting enzyme (TACE/ADAM-17) to release soluble TNF, a cytokine with potent antitumor properties whose use in clinical...
- REIC/Dkk-3 overexpression downregulates P-glycoprotein in multidrug-resistant MCF7/ADR cells and induces apoptosis in breast cancer
[作者：Kawasaki, K; Watanabe, M; Sakaguchi, M; Ogasawara, Y; Ochiai, K; Nasu, Y; Doihara, H; Kashiwakura, Y; Huh, NH; Kumon, H; Date, H,期刊：Cancer gene therapy, 页码：65-72 , 文章类型： Article，,卷期：2009年16-1]
- The overexpression of reduced expression in immortalized cells (REIC)/Dickkopf-3 (Dkk-3), a tumor suppressor gene, induced apoptosis in human prostatic and testicular cancer cells. The aim of this study is to examine the...
- Enhanced combined tumor-specific oncolysis and suicide gene therapy for prostate cancer using M6 promoter
[作者：Ahn, M; Lee, SJ; Li, X; Jimenez, JA; Zhang, YP; Bae, KH; Mohammadi, Y; Kao, C; Gardner, TA,期刊：Cancer gene therapy, 页码：73-82 , 文章类型： Article，,卷期：2009年16-1]
- Enzyme pro-drug suicide gene therapy has been hindered by inefficient viral delivery and gene transduction. To further explore the potential of this approach, we have developed AdIU1, a prostate-restricted replicative ad...
- Hapten-derivatized nanoparticle targeting and imaging of gene expression by multimodality imaging systems
[作者：Cheng, CM; Chu, PY; Chuang, KH; Roffler, SR; Kao, CH; Tseng, WL; Shiea, J; Chang, WD; Su, YC; Chen, BM; Wang, YM; Cheng, TL,期刊：Cancer gene therapy, 页码：83-90 , 文章类型： Article，,卷期：2009年16-1]
- Non-invasive gene monitoring is important for most gene therapy applications to ensure selective gene transfer to specific cells or tissues. We developed a non-invasive imaging system to assess the location and persisten...
- Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response
[作者：Neves, S; Faneca, H; Bertin, S; Konopka, K; Duzgunes, N; Pierrefite-Carle, V; Simoes, S; de Lima, MCP,期刊：Cancer gene therapy, 页码：91-101 , 文章类型： Article，,卷期：2009年16-1]
- Suicide gene therapy has been used for the treatment of a variety of cancers. We reported previously the in vitro efficacy of the Herpes Simplex Virus Thymidine kinase (HSV-tk)/ganciclovir (GCV) system to mediate cytotox...
- Recent advances in p53 research: an interdisciplinary perspective
[作者：Olivier, M; Petitjean, A; Marcel, V; Petre, A; Mounawar, M; Plymoth, A; de Fromentel, CC; Hainaut, P,期刊：Cancer gene therapy, 页码：1-12 , 文章类型： Review，,卷期：2009年16-1]
- The TP53 gene is one of the most studied genes in human cancer. In recent years, considerable interest was focused on mutant p53, the abnormal protein product of TP53 somatic or germline alleles with missense mutations t...
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