- Helicobacter pylori CagA targets gastric tumor suppressor RUNX3 for proteasome-mediated degradation
[作者：Tsang, YH; Lamb, A; Romero-Gallo, J; Huang, B; Ito, K; Peek, RM; Ito, Y; Chen, LF,期刊：Oncogene, 页码：5643-5650 , 文章类型： Article，,卷期：2010年29-41]
- Chronic infection with cagA-positive Helicobacter pylori is the strongest risk factor for the development of gastric adenocarcinoma. The cagA gene product CagA is injected into gastric epithelial cells and disturbs cellu...
- p66(Shc) restrains Ras hyperactivation and suppresses metastatic behavior
[作者：Ma, Z; Liu, Z; Wu, RF; Terada, LS,期刊：Oncogene, 页码：5559-5567 , 文章类型： Article，,卷期：2010年29-41]
- Normal tissue cells survive and proliferate only while anchored to solid substrate. Conversely, transformed cells both survive and proliferate following detachment, having lost attachment context through unclear mechanis...
- PIASy stimulates HIF1 alpha SUMOylation and negatively regulates HIF1 alpha activity in response to hypoxia
[作者：Kang, X; Li, J; Zou, Y; Yi, J; Zhang, H; Cao, M; Yeh, ETH; Cheng, J,期刊：Oncogene, 页码：5568-5578 , 文章类型： Article，,卷期：2010年29-41]
- Hypoxia-inducible factor-1 alpha (HIF1 alpha) is a crucial regulator of the cellular response to hypoxia through its regulation of genes that control erythropoiesis, angiogenesis and anaerobic metabolism. We have previou...
- Accelerated DNA replication in E2F1-and E2F2-deficient macrophages leads to induction of the DNA damage response and p21(CIP1)-dependent senescence
[作者：Iglesias-Ara, A; Zenarruzabeitia, O; Fernandez-Rueda, J; Sanchez-Tillo, E; Field, SJ; Celada, A; Zubiaga, AM,期刊：Oncogene, 页码：5579-5590 , 文章类型： Article，,卷期：2010年29-41]
- E2F1-3 proteins appear to have distinct roles in progenitor cells and in differentiating cells undergoing cell cycle exit. However, the function of these proteins in paradigms of terminal differentiation that involve con...
- Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cells
[作者：Kreis, NN; Sanhaji, M; Kramer, A; Sommer, K; Rodel, F; Strebhardt, K; Yuan, J,期刊：Oncogene, 页码：5591-5603 , 文章类型： Article，,卷期：2010年29-41]
- Abrogation of functional p53 is responsible for malignant cell transformation and the maintenance of malignant state of human papillomavirus-infected cancer cells. Thus, restoration of p53 has been regarded as an importa...
- Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment
[作者：Santonico, E; Belleudi, F; Panni, S; Torrisi, MR; Cesareni, G; Castagnoli, L,期刊：Oncogene, 页码：5604-5618 , 文章类型： Article，,卷期：2010年29-41]
- Ring finger protein 11 (RNF11) is a small RING E3-ligase overexpressed in numerous human prostate, colon and invasive breast cancers. Although functional studies have implicated RNF11 in a variety of biological processes...
- Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation
[作者：Yamaguchi, H; Chen, CT; Chou, CK; Pal, A; Bornmann, W; Hortobagyi, GN; Hung, MC,期刊：Oncogene, 页码：5619-5629 , 文章类型： Article，,卷期：2010年29-41]
- Histone deacetylase inhibitors (HDACi) are potent anticancer agents for variety of cancer types. Suberoylanilide hydroxamic acid (SAHA) has been approved as a drug to treat cutaneous T cell lymphoma, and the combination ...
- Neuropeptide Y and its Y2 receptor: potential targets in neuroblastoma therapy
[作者：Lu, C; Everhart, L; Tilan, J; Kuo, L; Sun, CCJ; Munivenkatappa, RB; Jonsson-Rylander, AC; Sun, J; Kuan-Celarier, A; Li, L; Abe, K; Zukowska, Z; Toretsky, JA; Kitlinska, J,期刊：Oncogene, 页码：5630-5642 , 文章类型： Article，,卷期：2010年29-41]
- Neuroblastomas are pediatric tumors that develop from sympathetic precursors and express neuronal proteins, such as neuropeptide Y (NPY). NPY is a sympathetic neurotransmitter acting via multiple receptors (Y1-Y5R). Both...
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