- Hedgehog signaling maintains chemoresistance in myeloid leukemic cells
[作者：Queiroz, KCS; Ruela-de-Sousa, RR; Fuhler, GM; Aberson, HL; Ferreira, CV; Peppelenbosch, MP; Spek, CA,期刊：Oncogene, 页码：6314-6322 , 文章类型： Article，,卷期：2010年29-48]
- The development of resistance against chemotherapy remains one of the major challenges in the clinical management of leukemia. There is still limited insight into the molecular mechanisms that maintain the chemotherapy-r...
- Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma
[作者：Zibat, A; Missiaglia, E; Rosenberger, A; Pritchard-Jones, K; Shipley, J; Hahn, H; Fulda, S,期刊：Oncogene, 页码：6323-6330 , 文章类型： Article，,卷期：2010年29-48]
- Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and comprises two major histological subtypes: alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS). Seventy-five percent of ARM...
- DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway
[作者：Ocak, S; Yamashita, H; Udyavar, AR; Miller, AN; Gonzalez, AL; Zou, Y; Jiang, A; Yi, Y; Shyr, Y; Estrada, L; Quaranta, V; Massion, PP,期刊：Oncogene, 页码：6331-6342 , 文章类型： Article，,卷期：2010年29-48]
- Small-cell lung cancer (SCLC) is the most aggressive subtype of lung cancer in its clinical behavior, with a 5-year overall survival as low as 5%. Despite years of research in the field, molecular determinants of SCLC be...
- Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1
[作者：Kalra, J; Sutherland, BW; Stratford, AL; Dragowska, W; Gelmon, KA; Dedhar, S; Dunn, SE; Bally, MB,期刊：Oncogene, 页码：6343-6356 , 文章类型： Article，,卷期：2010年29-48]
- In a previous study it was found that the therapeutic effects of QLT0267, a small molecule inhibitor of integrin-linked kinase (ILK), were influenced by Her2/neu expression. To understand how inhibition or silencing of I...
- Identification of Siah-interacting protein as a potential regulator of apoptosis and curcumin resistance
[作者：Luo, J; Yang, J; Yu, BY; Liu, W; Li, M; Zhuang, SM,期刊：Oncogene, 页码：6357-6366 , 文章类型： Article，,卷期：2010年29-48]
- The mechanism underlying curcumin (diferuloylmethane) resistance is still largely unknown. Here we employed proteomic approach to identify the Siah-interacting protein (SIP) as a candidate for detailed study, because the...
- Insulin-like growth factor 1 receptor antibody induces rhabdomyosarcoma cell death via a process involving AKT and Bcl-x(L)
[作者：Mayeenuddin, LH; Yu, Y; Kang, Z; Helman, LJ; Cao, L,期刊：Oncogene, 页码：6367-6377 , 文章类型： Article，,卷期：2010年29-48]
- Insulin-like growth factors (IGFs) and their receptor, IGF-1 receptor (IGF1R), have important roles in growth, development, stress response, aging and cancer. There are many agents that inhibit IGF1R in oncology clinical...
- Proteins that bind the Src homology 3 domain of CrkI have distinct roles in Crk transformation
[作者：Zheng, J; Machida, K; Antoku, S; Ng, KY; Claffey, KP; Mayer, BJ,期刊：Oncogene, 页码：6378-6389 , 文章类型： Article，,卷期：2010年29-48]
- The v-Crk oncogene product consists of two protein interaction modules, a Src homology 2 (SH2) domain and a Src homology 3 (SH3) domain. Overexpression of CrkI, the cellular homolog of v-Crk, transforms mouse fibroblasts...
- CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer
[作者：Lujambio, A; Portela, A; Liz, J; Melo, SA; Rossi, S; Spizzo, R; Croce, CM; Calin, GA; Esteller, M,期刊：Oncogene, 页码：6390-6401 , 文章类型： Article，,卷期：2010年29-48]
- Although only 1.5% of the human genome appears to code for proteins, much effort in cancer research has been devoted to this minimal fraction of our DNA. However, the last few years have witnessed the realization that a ...
- c-Src differentially regulates the functions of microtentacles and invadopodia
[作者：Balzer, EM; Whipple, RA; Thompson, K; Boggs, AE; Slovic, J; Cho, EH; Matrone, MA; Yoneda, T; Mueller, SC; Martin, SS,期刊：Oncogene, 页码：6402-6408 , 文章类型： Article，,卷期：2010年29-48]
- During metastasis, invading cells produce various actin-based membrane protrusions that promote directional migration and proteolysis of extracellular matrix (ECM). Observations of actin staining within thin, tubulin-bas...
- Harnessing the immune response to treat cancer
[作者：Steer, HJ; Lake, RA; Nowak, AK; Robinson, BWS,期刊：Oncogene, 页码：6301-6313 , 文章类型： Review，,卷期：2010年29-48]
- It is well established that the immune system has the capacity to attack malignant cells. During malignant transformation cells acquire numerous molecular and biochemical changes that render them potentially vulnerable t...
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