- Pulsatile release of biomolecules from polydimethylsiloxane (PDMS) chips with hydrolytically degradable seals
[作者:Intra, J; Glasgow, JA; Mai, HQ; Salem, AK,期刊:Journal of controlled release, 页码:280-287 , 文章类型: Article,,卷期:2008年127-3]
- We demonstrate, for the first time, a robust novel polydimethylsiloxane (PDMS) chip that can provide controlled pulsatile release of DNA based molecules, proteins and oligonucleotides without external stimuli or triggers...
- Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy
[作者:Min, KH; Park, K; Kim, YS; Bae, SM; Lee, S; Jo, HG; Park, RW; Kim, IS; Jeong, SY; Kim, K; Kwon, IC,期刊:Journal of controlled release, 页码:208-218 , 文章类型: Article,,卷期:2008年127-3]
- To prepare a water-insoluble camptothecin (CPT) delivery carrier, hydrophobically modified glycol chitosan (HGC) nanoparticles were constructed by chemical conjugation of hydrophobic 5 beta-cholanic acid moieties to the ...
- In vivo antitumor activity of camptothecin incorporated in liposomes formulated with an artificial lipid and human serum albumin
[作者:Watanabe, M; Kawano, K; Toma, K; Hattori, Y; Maitani, Y,期刊:Journal of controlled release, 页码:231-238 , 文章类型: Article,,卷期:2008年127-3]
- Camptothecin (CPT) is a strong antitumor agent, but its use limited by its low solubility and the instability of the active lactone form. To overcome these difficulties, liposomes incorporating CPT (CPT liposomes) were d...
- Antitumoral activity of PEG-gemcitabine prodrugs targeted by folic acid
[作者:Pasut, G; Canal, F; Via, LD; Arpicco, S; Veronese, FA; Schiavon, O,期刊:Journal of controlled release, 页码:239-248 , 文章类型: Article,,卷期:2008年127-3]
- Gemcitabine, 2',2'-difluoro-2'-deoxycytidine (dFdC), is an antitumor agent effective in the treatment of several solid tumors but its use is hampered by short plasma half-life, rapid metabolism and low selectivity toward...
- Efficacy of pulmonary insulin delivery in diabetic rats: Use of a model-based approach in the evaluation of insulin powder formulations
[作者:Amidi, M; Krudys, KM; Snel, CJ; Crommelin, DJA; Della Pasqua, OE; Hennink, WE; Jiskoot, W,期刊:Journal of controlled release, 页码:257-266 , 文章类型: Article,,卷期:2008年127-3]
- The potential of N-trimethyl chitosan (TMC) with two degrees of quaternization (DQ), TMC20 (DQ 20%, as a mucoadhesive) and TMC60 (DQ 60%, as a mucoadhesive and a permeation enhancer), and dextran (as a non-mucoadhesive a...
- Synthesis and drug release properties of poly(ethylene oxide) segmented polysulfone copolymers
[作者:Gu, XZ; Kuang, YB; Guo, XX; Fang, HH; Ni, ZH,期刊:Journal of controlled release, 页码:267-272 , 文章类型: Article,,卷期:2008年127-3]
- A series of poly(ethylene oxide) (PEO) segmented polysulfone copolymers with different PEO content has been successfully synthesized via condensation polymerization of 4,4'-dichlorodiphenylsulfone (DCDPS), chlorine-end-c...
- Poly(imidazole/DMAEA)phosphazene/DNA self-assembled nanoparticles for gene delivery: Synthesis and in vitro transfection
[作者:Yang, YX; Xu, ZH; Jiang, JU; Gao, Y; Gu, WW; Chen, LL; Tang, XZ; Li, YP,期刊:Journal of controlled release, 页码:273-279 , 文章类型: Article,,卷期:2008年127-3]
- A new cationic derivate of polyphosphazene with imidazole and 2-dimethylaminoethylamino (DMAEA) as side groups, poly(imidazole/ DMAEA)phosphazene (PIDP), was synthesized and investigated for gene delivery. The half-lives...
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