- Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer
[作者:Kim, SH; Jeong, JH; Lee, SH; Kim, SW; Park, TG,期刊:Journal of controlled release, 页码:107-116 , 文章类型: Article,,卷期:2008年129-2]
- For efficient cancer therapy, small interfering RNA (siRNA) should be stably and efficiently delivered into the target tissue and readily taken up by cancer cells. To address these needs, a polyelectrolyte complex (PEC) ...
- High gene delivery in tumor by intratumoral injection of tetraarginine-PEG lipid-coated protamine/DNA
[作者:Fujita, T; Furuhata, M; Hattori, Y; Kawakami, H; Toma, K; Maitani, Y,期刊:Journal of controlled release, 页码:124-127 , 文章类型: Article,,卷期:2008年129-2]
- One obstacle to effective gene therapy lies in low transfection efficiency by non-viral vectors. To meet this challenge, we developed cell-penetrating peptide-based gene delivery vectors. A novel oligoarginine lipid ((Ar...
- Coating didodecyldimethylammonium bromide onto Au nanoparticles increases the stability of its complex with DNA
[作者:Li, PC; Zhang, LX; Ai, KL; Li, D; Liu, XH; Wang, EK,期刊:Journal of controlled release, 页码:128-134 , 文章类型: Article,,卷期:2008年129-2]
- The stability of the complex of cationic lipid with nucleic acid, especially when facing serum, is crucial for the efficiency of gene delivery. Here, we demonstrated that the stability of the complex of didodecyldimethyl...
- Module assemblage technology for floating systems: In vitro flotation and in vivo gastro-retention
[作者:Strusi, OL; Sonvico, F; Bettini, R; Santi, P; Colombo, G; Barata, P; Oliveira, A; Santos, D; Colombo, P,期刊:Journal of controlled release, 页码:88-92 , 文章类型: Article,,卷期:2008年129-2]
- The aim of this research was to study, in vitro by resultant-weight measurement and in vivo by gamma-scintigraphy experiments in humans, the floatation behavior of systems obtained by modules assembled in void configurat...
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