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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   Genetic mutations and functions of PINK1 [作者：Kawajiri, S; Saiki, S; Sato, S; Hattori, N,期刊：Trends in Pharmacological Sciences, 页码：573-580 , 文章类型： Review，,卷期：2011年32-10] Parkinson's disease (PD) is the second most common neurodegenerative disease. Mutations in PINK1 (PARK6) are the second most frequent cause of autosomal recessive, young-onset PD, after parkin (PARK2). PINK1 (a kinase wi... The delta opioid receptor: an evolving target for the treatment of brain disorders [作者：Pradhan, AA; Befort, K; Nozaki, C; Gaveriaux-Ruff, C; Kieffer, BL,期刊：Trends in Pharmacological Sciences, 页码：581-590 , 文章类型： Review，,卷期：2011年32-10] Compared to the better-known mu opioid receptor, delta opioid receptors have been relatively understudied. However, the development of highly selective delta opioid agonists and the availability of genetic mouse models h... Structural insights into RAMP modification of secretin family G protein-coupled receptors: implications for drug development [作者：Archbold, JK; Flanagan, JU; Watkins, HA; Gingell, JJ; Hay, DL,期刊：Trends in Pharmacological Sciences, 页码：591-600 , 文章类型： Review，,卷期：2011年32-10] Secretin family G protein-coupled receptors (GPCRs) are important therapeutic targets for migraine, diabetes, bone disorders, inflammatory disorders and cardiovascular disease. They possess a large N-terminal extracellul... Tuberculosis vaccines: progress and challenges [作者：Checkley, AM; McShane, H,期刊：Trends in Pharmacological Sciences, 页码：601-606 , 文章类型： Review，,卷期：2011年32-10] An effective tuberculosis (TB) vaccine could have a significant impact on the current TB pandemic. The past decade has seen sustained global investment into reaching this goal; currently there are several promising vacci... The role of metformin and thiazolidinediones in the regulation of hepatic glucose metabolism and its clinical impact [作者：Phielix, E; Szendroedi, J; Roden, M,期刊：Trends in Pharmacological Sciences, 页码：607-616 , 文章类型： Review，,卷期：2011年32-10] Fasting hyperglycemia in type 2 diabetes mellitus (T2DM) results from elevated endogenous glucose production (EGP), which is mostly due to augmented hepatic gluconeogenesis. Insulin-resistant humans exhibit impaired insu... Regulation of interleukin-1 in acute brain injury [作者：Brough, D; Tyrrell, PJ; Allan, SM,期刊：Trends in Pharmacological Sciences, 页码：617-622 , 文章类型： Review，,卷期：2011年32-10] Inflammation is a complex vascular response that has evolved to eliminate infection and to repair injured tissue. It is subject to tight regulatory control of its initiation and resolution. Failure of an inflammatory res... Systems genetics for drug target discovery [作者：Penrod, NM; Cowper-Sal-Iari, R; Moore, JH,期刊：Trends in Pharmacological Sciences, 页码：623-630 , 文章类型： Review，,卷期：2011年32-10] The collection and analysis of genomic data has the potential to reveal novel druggable targets by providing insight into the genetic basis of disease. However, the number of drugs targeting new molecular entities, appro...