- ROR gamma-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F
[作者:Leppkes, M; Becker, C; Ivanov, II; Hirth, S; Wirtz, S; Neufert, C; Pouly, S; Murphy, AJ; Valenzuela, DM; Yancopoulos, GD; Becher, B; Littman, DR; Neurath, MF,期刊:Gastroenterology, 页码:257-267 , 文章类型: Article,,卷期:2009年136-1]
- Background and Aims: IL-17-producing CD4(+) Thelper cells (Th17) contribute to chronic autoimmune inflammation in the brain, and levels of Th17-derived cytokines increase in patients with colitis, suggesting a role in pa...
- Obesity Increases the Risks of Diverticulitis and Diverticular Bleeding
[作者:Strate, LL; Liu, YL; Aldoori, WH; Syngal, S; Giovannucci, EL,期刊:Gastroenterology, 页码:115-122 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Studies of obesity and diverticular complications are limited. We assessed the relationship between body mass index (BMI), waist circumference, and waist-to-hip ratio and diverticulitis and diverticula...
- Degeneration of the Pericryptal Myofibroblast Sheath by Proinflammatory Cytokines in Inflammatory Bowel Diseases
[作者:Francoeur, C; Bouatrouss, Y; Seltana, A; Pinchuk, IV; Vachon, PH; Powell, DW; Sawan, B; Seidman, EG; Beaulieu, JF,期刊:Gastroenterology, 页码:268-277 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Inflammatory bowel diseases (IBDs) are characterized by remodeling of the intestinal mucosa, which is associated with excessive cytokine release. Previous studies have shown that the epithelium in the ...
- CpG Motifs of Bacterial DNA Exert Protective Effects in Mouse Models of IBD by Antigen-Independent Tolerance Induction
[作者:Bleich, A; Janus, LM; Smoczek, A; Westendorf, AM; Strauch, U; Mahler, M; Hedrich, HJ; Fichtner-Feigl, S; Scholmerich, J; Falk, W; Hofmann, C; Obermeier, F,期刊:Gastroenterology, 页码:278-287 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Prophylactic treatment of mice with CpG motifs of bacterial DNA protects from experimental inflammatory bowel disease, at least partly via induction of inhibitory T-cells. The aim of this study was to ...
- Longitudinal Assessment of Bone Density and Structure in an Incident Cohort of Children With Crohn's Disease
[作者:Dubner, SE; Shults, J; Baldassano, RN; Zemel, BS; Thayu, M; Burnham, JM; Herskovitz, RM; Howard, KM; Leonarda, MB,期刊:Gastroenterology, 页码:123-130 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: The impact of childhood Crohn's disease (CD) on volumetric bone mineral density (vBMD), bone structure, and muscle mass have not been established. The objective of this longitudinal study was to assess...
- Polymeric Binders Suppress Gliadin-Induced Toxicity in the Intestinal Epithelium
[作者:Pinier, M; Verdu, EF; Nasser-Eddine, M; David, CS; Vezina, A; Rivard, N; Leroux, JC,期刊:Gastroenterology, 页码:288-298 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Celiac disease is a prevalent immune disorder caused by the ingestion of gliadin-containing grains. We investigated the ability of a polymeric binder to reverse the toxic effects induced by gliadin in ...
- Chromosome 8q23.3 and 11q23.1 Variants Modify Colorectal Cancer Risk in Lynch Syndrome
[作者:Wijnen, JT; Brohet, RM; Van Eijk, R; Jagmohan-Changur, S; Middeldorp, A; Tops, CM; Van Puijenbroek, M; Ausems, MGEM; Garcia, EG; Hes, FJ; Hoogerbrugge, N; Menko, FH; Van Os, TAM; Sijmons, RH; Verhoef, S; Wagner, A; Nagengast, FM; Kleibeuker, JH; Devilee, P; Morreau, H; Goldgar, D; Tomlinson, IP; Houlston, RS; Van Wezel, T; Vasen, HFA,期刊:Gastroenterology, 页码:131-137 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Recent genome-wide association studies have identified common low-risk variants for colorectal cancer (CRC). To assess whether these influence CRC risk in the Lynch syndrome, we genotyped these variant...
- Incidence of Hepatocellular Carcinoma and Associated Risk Factors in Hepatitis C-Related Advanced Liver Disease
[作者:Lok, AS; Seeff, LB; Morgan, TR; Di Bisceglie, AM; Sterling, RK; Curto, TM; Everson, GT; Lindsay, KL; Lee, WM; Bonkovsky, HL; Dienstag, JL; Ghany, MG; Morishima, C; Goodman, ZD,期刊:Gastroenterology, 页码:138-148 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Although the incidence of hepatocellular carcinoma (HCC) is increasing in the United States, data from large prospective studies are limited. We evaluated the Hepatitis C Antiviral Long-Term Treatment ...
- Pancreatic Inactivation of c-Myc Decreases Acinar Mass and Transdifferentiates Acinar Cells Into Adipocytes in Mice
[作者:Bonal, C; Thorel, F; Ait-Lounis, A; Reith, W; Trumpp, A; Herrera, PL,期刊:Gastroenterology, 页码:309-319 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: The pancreatic mass is determined by the coordinated expansion and differentiation of progenitor cells and is maintained via tight control of cell replacement rates. The basic helix-loop-helix transcri...
- A Randomized Controlled Trial of Antioxidant Supplementation for Pain Relief in Patients With Chronic Pancreatitis
[作者:Bhardwaj, P; Garg, PK; Maulik, SK; Saraya, A; Tandon, RK; Acharya, SK,期刊:Gastroenterology, 页码:149-159 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Oxidative stress has been implicated in the pathophysiology of chronic pancreatitis (CP). We evaluated the effects of antioxidant supplementation on pain relief, oxidative stress, and antioxidant statu...
- Liver Cell-Derived Microparticles Activate Hedgehog Signaling and Alter Gene Expression in Hepatic Endothelial Cells
[作者:Witek, RP; Yang, L; Liu, RS; Jung, YM; Omenetti, A; Syn, WK; Choi, SS; Cheong, YW; Fearing, CM; Agboola, KM; Chen, W; Diehl, AM,期刊:Gastroenterology, 页码:320-330 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Angiogenesis contributes to vascular remodeling during cirrhosis. in cirrhotic livers, cholangiocytes, and myofibroblastic hepatic stellate cells (MF-HSC) produce Hedgehog (Hh) ligands. During embryoge...
- Performance of ELF Serum Markers in Predicting Fibrosis Stage in Pediatric Non-Alcoholic Fatty Liver Disease
[作者:Nobili, V; Parkes, J; Bottazzo, G; Marcellini, M; Cross, R; Newman, D; Vizzutti, F; Pinzani, M; Rosenberg, WM,期刊:Gastroenterology, 页码:160-167 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease in children and adolescents in industrialized countries. It is important to accurately determine the stage of fibrosi...
- Ethanol Exposure Depletes Hepatic Pigment Epithelium-Derived Factor, a Novel Lipid Regulator
[作者:Chung, CH; Shugrue, C; Nagar, A; Doll, JA; Cornwell, M; Gattu, A; Kolodecik, T; Pandol, SJ; Gorelick, F,期刊:Gastroenterology, 页码:331-340 , 文章类型: Article,,卷期:2009年136-1]
- Background & Aims: Ethanol abuse can lead to hepatic steatosis and evolve into cirrhosis and hepatocellular carcinoma. Pigment epithelium-derived factor (PEDF) is a multifunctional secreted glycoprotein. that is expresse...
|