- Effect of excipients on breast cancer resistance protein substrate uptake activity
[作者:Yamagata, T; Kusuhara, H; Morishita, M; Takayama, K; Benameur, H; Sugiyama, Y,期刊:Journal of controlled release, 页码:1-5 , 文章类型: Article,,卷期:2007年124-39815]
- Breast cancer resistance protein (BCRP/ABCG2) plays an important role in drug disposition. To examine whether some currently used excipients could inhibit its function, we measured the uptake of [H-3]mitoxantrone in BCRP...
- A new nanomedicine of gemcitabine displays enhanced anticancer activity in sensitive and resistant leukemia types
[作者:Reddy, LH; Dubernet, C; Mouelhi, SL; Marque, PE; Desmaele, D; Couvreur, P,期刊:Journal of controlled release, 页码:20-27 , 文章类型: Article,,卷期:2007年124-39815]
- Gemcitabine is an anticancer nucleoside analogue active against various solid tumors. However, it possesses important drawbacks like a poor biological half-life and the induction of resistance. With the objective of over...
- Folate-mediated tumor cell uptake of quantum dots entrapped in lipid nanoparticles
[作者:Schroeder, JE; Shweky, I; Shmeeda, H; Banin, U; Gabizon, A,期刊:Journal of controlled release, 页码:28-34 , 文章类型: Article,,卷期:2007年124-39815]
- Quantum dots (QDs) are fluorescent semiconductor nanocrystals with superior optical properties compared to organic dyes currently undergoing rapid development for biological applications, particularly in fluorescence ima...
- Binding specificity and internalization properties of an antibody - avidin fusion protein targeting the human transferrin receptor
[作者:Rodriguez, JA; Helguera, G; Daniels, TR; Neacato, II; Lopez-Valdes, HE; Charles, AC; Penichet, ML,期刊:Journal of controlled release, 页码:35-42 , 文章类型: Article,,卷期:2007年124-39815]
- The human transferrin receptor (hTfR1) is a membrane-bound protein involved in transferrin (Tf)-mediated iron uptake and is highly expressed on malignant cells. A second version of the receptor (hTfR2) also mediates Tf-d...
- In vitro assessment of a novel polyrotaxane-based drug delivery system integrated with a cell-penetrating peptide
[作者:Moon, C; Kwon, YM; Lee, WK; Park, YJ; Yang, VC,期刊:Journal of controlled release, 页码:43-50 , 文章类型: Article,,卷期:2007年124-39815]
- In the development of anti-cancer drugs, it is important to yield selective cytotoxicity primarily against tumor tissues. To achieve this goal, the use of a polymer-drug conjugate appears to be appealing, simply because ...
- In vitro and in vivo test of PEG/PCL-based hydrogel scaffold for cell delivery application
[作者:Park, JS; Woo, DG; Sun, BK; Chung, HM; Im, SJ; Choi, YM; Park, K; Huh, KM; Park, KH,期刊:Journal of controlled release, 页码:51-59 , 文章类型: Article,,卷期:2007年124-39815]
- Biodegradable elastic hydrogel scaffolds based on hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(e-caprolactone) (PCL) were fabricated and investigated as a delivery vehicle of rabbit chondrocytes for the f...
- Involvement of organic anion transport system in transdermal absorption of flurbiprofen
[作者:Ito, K; Kato, Y; Tsuji, H; Nguyen, HT; Kubo, Y; Tsuji, A,期刊:Journal of controlled release, 页码:60-68 , 文章类型: Article,,卷期:2007年124-39815]
- We previously demonstrated that transdermal permeation of flurbiprofen is mediated by a nonlinear transport mechanism(s). Here, we aimed to characterize this transport mechanism by employing an Ussing-type chamber method...
- Optimisation of intradennal DNA electrotransfer for immunisation
[作者:Vandermeulen, G; Staes, E; Vanderhaeghen, ML; Bureau, MF; Scherman, D; Preat, V,期刊:Journal of controlled release, 页码:81-87 , 文章类型: Article,,卷期:2007年124-39815]
- The development of DNA vaccines requires appropriate delivery technologies. Electrotransfer is one of the most efficient methods of non-viral gene transfer. In the present study, intradermal DNA electrotransfer was first...
- Piezoelectric control of needle-free transdermal drug delivery
[作者:Stachowiak, JC; von Muhlen, MG; Li, TH; Jalilian, L; Parekh, SH; Fletcher, DA,期刊:Journal of controlled release, 页码:88-97 , 文章类型: Article,,卷期:2007年124-39815]
- Transdermal drug delivery occurs primarily through hypodermic needle injections, which cause pain, require a trained administrator, and may contribute to the spread of disease. With the growing number of pharmaceutical t...
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