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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共8条记录   Zeb1 is required for TrkB-induced epithelial-mesenchymal transition, anoikis resistance and metastasis [作者：Smit, MA; Peeper, DS,期刊：Oncogene, 页码：3735-3744 , 文章类型： Article，,卷期：2011年30-35] Anoikis (detachment-induced apoptosis) prevents the survival of cells at inappropriate sites of the body and can therefore act as a barrier to metastasis. In a function-based genome-wide screen, we have previously identi... ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability [作者：Goetz, EM; Shankar, B; Zou, Y; Morales, JC; Luo, X; Araki, S; Bachoo, R; Mayo, LD; Boothman, DA,期刊：Oncogene, 页码：3745-3754 , 文章类型： Article，,卷期：2011年30-35] Secretory clusterin (sCLU) is a stress-induced, prosurvival glycoprotein elevated in early-stage cancers, in particular in APC/Min-defective colon cancers. sCLU is upregulated after exposure to various cytotoxic agents, ... ATM-mediated phosphorylation activates the tumor-suppressive function of B56 gamma-PP2A [作者：Shouse, GP; Nobumori, Y; Panowicz, MJ; Liu, X,期刊：Oncogene, 页码：3755-3765 , 文章类型： Article，,卷期：2011年30-35] Protein phosphatase 2A (PP2A) is a family of heterotrimeric protein phosphatases that has a multitude of functions inside the cell, acting through various substrate targets in cell-signaling pathways. Recent evidence sug... Type IV collagen-initiated signals provide survival and growth cues required for liver metastasis [作者：Burnier, JV; Wang, N; Michel, RP; Hassanain, M; Li, S; Lu, Y; Metrakos, P; Antecka, E; Burnier, MN; Ponton, A; Gallinger, S; Brodt, P,期刊：Oncogene, 页码：3766-3783 , 文章类型： Article，,卷期：2011年30-35] The liver is a major site of metastasis for human malignancies, yet the factors that regulate tumor cell survival and growth in this organ remain elusive. Previously, we reported that M-27(IGF-IR) murine lung carcinoma c... Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer [作者：Gill, RK; Yang, SH; Meerzaman, D; Mechanic, LE; Bowman, ED; Jeon, HS; Chowdhuri, SR; Shakoori, A; Dracheva, T; Hong, KM; Fukuoka, J; Zhang, JH; Harris, CC; Jen, J,期刊：Oncogene, 页码：3784-3791 , 文章类型： Article，,卷期：2011年30-35] LKB1/STK11 is a tumor suppressor and a negative regulator of mammalian target of rapamycin signaling. It is inactivated in 30% of lung cancer cell lines but only 5-15% of primary lung adenocarcinomas. There is evidence t... TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1 [作者：Jin, HO; Seo, SK; Kim, YS; Woo, SH; Lee, KH; Yi, JY; Lee, SJ; Choe, TB; Lee, JH; An, S; Hong, SI; Park, IC,期刊：Oncogene, 页码：3792-3801 , 文章类型： Article，,卷期：2011年30-35] The mammalian target of rapamycin (mTOR) is a highly conserved serine-threonine kinase activated in response to growth factors and nutrients. Because of frequent dysregulation of the mTOR signaling pathway in diverse hum... Oncogenic role of EAPII in lung cancer development and its activation of the MAPK-ERK pathway [作者：Li, C; Fan, S; Owonikoko, TK; Khuri, FR; Sun, SY; Li, R,期刊：Oncogene, 页码：3802-3812 , 文章类型： Article，,卷期：2011年30-35] Cancer progression involves multiple complex and interdependent steps, including progressive proliferation, angiogenesis and metastases. The complexity of these processes requires a comprehensive elucidation of the integ... Dual-specificity phosphatase DUSP6 has tumor-promoting properties in human glioblastomas [作者：Messina, S; Frati, L; Leonetti, C; Zuchegna, C; Di Zazzo, E; Calogero, A; Porcellini, A,期刊：Oncogene, 页码：3813-3820 , 文章类型： Article，,卷期：2011年30-35] Dual-specificity phosphatase 6 (DUSP6, mitogen-activated protein kinase (MAPK) phosphatase 3 or PYST1) dephosphorylates phosphotyrosine and phosphothreonine residues on extracellular signal-regulated kinase (ERK1/2; MAPK...