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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   In melanoma, beta-catenin is a suppressor of invasion [作者：Arozarena, I; Bischof, H; Gilby, D; Belloni, B; Dummer, R; Wellbrock, C,期刊：Oncogene, 页码：4531-4543 , 文章类型： Article，,卷期：2011年30-45] Cell-type-specific signalling determines cell fate under physiological conditions, but it is increasingly apparent that also in cancer development the impact of any given oncogenic pathway on the individual cancer pathol... Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study [作者：Shen, S; Kepp, O; Michaud, M; Martins, I; Minoux, H; Metivier, D; Maiuri, MC; Kroemer, RT; Kroemer, G,期刊：Oncogene, 页码：4544-4556 , 文章类型： Article，,卷期：2011年30-45] To address the question of whether established or experimental anticancer chemotherapeutics can exert their cytotoxic effects by autophagy, we performed a high-content screen on a set of cytotoxic agents. We simultaneous... NF-kappa B suppresses ROS levels in BCR-ABL(+) cells to prevent activation of JNK and cell death [作者：Stein, SJ; Baldwin, AS,期刊：Oncogene, 页码：4557-4566 , 文章类型： Article，,卷期：2011年30-45] Elevated levels of reactive oxygen species (ROS) are found in most oncogenically transformed cells and are proposed to promote cellular transformation through mechanisms such as inhibition of phosphatases. BCR-ABL, the o... Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling [作者：Lu, Y; Muller, M; Smith, D; Dutta, B; Komurov, K; Iadevaia, S; Ruths, D; Tseng, JT; Yu, S; Yu, Q; Nakhleh, L; Balazsi, G; Donnelly, J; Schurdak, M; Morgan-Lappe, S; Fesik, S; Ram, PT; Mills, GB,期刊：Oncogene, 页码：4567-4577 , 文章类型： Article，,卷期：2011年30-45] To identify regulators of intracellular signaling, we targeted 541 kinases and kinase-related molecules with small interfering RNAs (siRNAs), and determined their effects on signaling with a functional proteomics reverse... Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1 alpha mediated by the PTEN/PI3K/Akt pathway [作者：Park, JH; Lee, JY; Shin, DH; Jang, KS; Kim, HJ; Kong, G,期刊：Oncogene, 页码：4578-4589 , 文章类型： Article，,卷期：2011年30-45] Mel-18 has been implicated in several processes in tumor progression, in which the Akt pathway is involved as an important key molecular event. However, the function of Mel-18 in human cancers has not been fully establis... RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma [作者：Yang, D; Tao, J; Li, L; Kedei, N; Toth, ZE; Czap, A; Velasquez, JF; Mihova, D; Michalowski, AM; Yuspa, SH; Blumberg, PM,期刊：Oncogene, 页码：4590-4600 , 文章类型： Article，,卷期：2011年30-45] RasGRP3, an activator for H-Ras, R-Ras and Ras-associated protein-1/2, has emerged as an important mediator of signaling downstream from receptor coupled phosphoinositide turnover in B and T cells. Here, we report that R... Role of connexin43 and ATP in long-range bystander radiation damage and oncogenesis in vivo [作者：Mancuso, M; Pasquali, E; Leonardi, S; Rebessi, S; Tanori, M; Giardullo, P; Borra, F; Pazzaglia, S; Naus, CC; Di Majo, V; Saran, A,期刊：Oncogene, 页码：4601-4608 , 文章类型： Article，,卷期：2011年30-45] Ionizing radiation is a genotoxic agent and human carcinogen. Recent work has questioned long-held dogmas by showing that cancer-associated genetic alterations occur in cells and tissues not directly exposed to radiation...