- Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain
[作者:Mirzadeh, Z; Merkle, FT; Soriano-Navarro, M; Garcia-Verdugo, JM; Alvarez-Buylla, A,期刊:Cell Stem Cell, 页码:265-278 , 文章类型: Article,,卷期:2008年3-3]
- Neural stem cells (NSCs, B1 cells) are retained in the walls of the adult lateral ventricles but, unlike embryonic NSCs, are displaced from the ventricular zone (VZ) into the subventricular zone (SVZ) by ependymal cells....
- A specialized vascular niche for adult neural stem cells
[作者:Tavazoie, M; Van der Veken, L; Silva-Vargas, V; Louissaint, M; Colonna, L; Zaidi, B; Garcia-Verdugo, JM; Doetsch, F,期刊:Cell Stem Cell, 页码:279-288 , 文章类型: Article,,卷期:2008年3-3]
- Stem cells reside in specialized niches that regulate their self-renewal and differentiation. The vasculature is emerging as an important component of stem cell niches. Here, we show that the adult sub-ventricular zone (...
- Adult SVZ stem cells lie in a vascular niche: A quantitative analysis of niche cell-cell interactions
[作者:Shen, Q; Wang, Y; Kokovay, E; Lin, G; Chuang, SM; Goderie, SK; Roysam, B; Temple, S,期刊:Cell Stem Cell, 页码:289-300 , 文章类型: Article,,卷期:2008年3-3]
- There is an emerging understanding of the importance of the vascular system within stem cell niches. Here, we examine whether neural stem cells (NSCs) in the adult subventricular zone (SVZ) lie close to blood vessels, us...
- A perivascular origin for mesenchymal stem cells in multiple human organs
[作者:Crisan, M; Yap, S; Casteilla, L; Chen, CW; Corselli, M; Park, TS; Andriolo, G; Sun, B; Zheng, B; Zhang, L; Norotte, C; Teng, PN; Traas, J; Schugar, R; Deasy, BM; Badylak, S; Buhring, HJ; Giacobino, JP; Lazzari, L; Huard, J; Peault, B,期刊:Cell Stem Cell, 页码:301-313 , 文章类型: Article,,卷期:2008年3-3]
- Mesenchymal stem cells (MSCs), the archetypal multipotent progenitor cells derived in cultures of developed organs, are of unknown identity and native distribution. We have prospectively identified perivascular cells, pr...
- Notch signaling specifies megakaryocyte development from hematopoietic stem cells
[作者:Mercher, T; Cornejo, MG; Sears, C; Kindler, T; Moore, SA; Maillard, I; Pear, WS; Aster, JC; Gilliland, DG,期刊:Cell Stem Cell, 页码:314-326 , 文章类型: Article,,卷期:2008年3-3]
- In the hematopoietic system, Notch signaling specifies T cell lineage fate, in part through negative regulation of B cell and myeloid lineage development. However, we unexpectedly observed the development of megakaryocyt...
- A high-efficiency system for the generation and study of human induced pluripotent stem cells
[作者:Maherali, N; Ahfeldt, T; Rigamonti, A; Utikal, J; Cowan, C; Hochedlinger, K,期刊:Cell Stem Cell, 页码:340-345 , 文章类型: Article,,卷期:2008年3-3]
- Direct reprogramming of human fibroblasts to a pluripotent state has been achieved through ectopic expression of the transcription factors OCT4, SOX2, and either cMYC and KLF4 or NANOG and LIN28. Little is known, however...
- A drug-inducible system for direct reprogramming of human somatic cells to pluripotency
[作者:Hockemeyer, D; Soldner, F; Cook, EG; Gao, Q; Mitalipova, M; Jaenisch, R,期刊:Cell Stem Cell, 页码:346-353 , 文章类型: Article,,卷期:2008年3-3]
- Current approaches to reprogram human somatic cells to pluripotent iPSCs utilize viral transduction of different combinations of transcription factors. These protocols are highly inefficient because only a small fraction...
- All MSCs are pericytes?
[作者:Caplan, AI,期刊:Cell Stem Cell, 页码:229-230 , 文章类型: Editorial Material,,卷期:2008年3-3]
- In this issue of Cell Stem Cell, Crisan et al. (2008) document a subpopulation of human perivascular cells that express both pericyte and mesenchymal stem cell (MSC) markers in situ. The isolated population can expand an...
- The niche revealed
[作者:Currle, DS; Gilbertson, RJ,期刊:Cell Stem Cell, 页码:234-236 , 文章类型: Editorial Material,,卷期:2008年3-3]
- A trio of studies in this issue of Cell Stem Cell from Mirzadeh et al., Shen et al., and Tavazoie et al. use three-dimensional imaging techniques to reveal microanatomical details of the adult neural stem cell niche. Com...
- Induced pluripotent stem cells and human disease
[作者:Colman, A,期刊:Cell Stem Cell, 页码:236-237 , 文章类型: Editorial Material,,卷期:2008年3-3]
- Two recent studies report the generation of induced pluripotent stem cells from patients presenting with a total of eleven different diseases (Park et al., 2008; Dimos et al., 2008). Future differentiation studies using ...
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