- Enhanced Foam Cell Formation, Atherosclerotic Lesion Development, and Inflammation by Combined Deletion of ABCA1 and SR-BI in Bone Marrow-Derived Cells in LDL Receptor Knockout Mice on Western-Type Diet
[作者:Zhao, Y; Pennings, M; Hildebrand, RB; Ye, D; Calpe-Berdiel, L; Out, R; Kjerrulf, M; Hurt-Camejo, E; Groen, AK; Hoekstra, M; Jessup, W; Chimini, G; Van Berkel, TJC; Van Eck, M,期刊:Circulation Research, 页码:E20-+ , 文章类型: Article,,卷期:2010年107-12]
- Rationale: Macrophages cannot limit the uptake of lipids and rely on cholesterol efflux mechanisms for maintaining cellular cholesterol homeostasis. Important mediators of macrophage cholesterol efflux are ATP-binding ca...
- Myocardial Lineage Development
[作者:Evans, SM; Yelon, D; Conlon, FL; Kirby, ML,期刊:Circulation Research, 页码:1428-1444 , 文章类型: Review,,卷期:2010年107-12]
- The myocardium of the heart is composed of multiple highly specialized myocardial lineages, including those of the ventricular and atrial myocardium, and the specialized conduction system. Specification and maturation of...
- A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse
[作者:Gao, E; Lei, YH; Shang, XY; Huang, ZM; Zuo, L; Boucher, M; Fan, QA; Chuprun, JK; Ma, XL; Koch, WJ,期刊:Circulation Research, 页码:1445-+ , 文章类型: Article,,卷期:2010年107-12]
- Rationale: Coronary artery ligation to induce myocardial infarction (MI) in mice is typically performed by an invasive and time-consuming approach that requires ventilation and chest opening (classic method), often resul...
- Muscle-Specific F-Box Only Proteins Facilitate BK Channel beta(1) Subunit Downregulation in Vascular Smooth Muscle Cells of Diabetes Mellitus
[作者:Zhang, DM; He, TR; Katusic, ZS; Lee, HC; Lu, T,期刊:Circulation Research, 页码:1454-+ , 文章类型: Article,,卷期:2010年107-12]
- Rationale: Activity of the large conductance Ca2+-activated K+ (BK) channels is profoundly modulated by its beta(1) subunit (BK-beta(1)). However, BK-beta(1) expression is downregulated in diabetic vessels. The ubiquitin...
- Clonal Analysis Reveals a Common Progenitor for Endothelial, Myeloid, and Lymphoid Precursors in Umbilical Cord Blood
[作者:Ramos, AL; Darabi, R; Akbarloo, N; Borges, L; Catanese, J; Dineen, SP; Brekken, RA; Perlingeiro, RCR,期刊:Circulation Research, 页码:1460-+ , 文章类型: Article,,卷期:2010年107-12]
- Rationale: Several studies demonstrate that hematopoietic tissues are a source of endothelial progenitor cells, which contribute to newly formed blood vessels during tissue repair in adults. However, it is not clear whic...
- Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
[作者:Hariharan, N; Maejima, Y; Nakae, J; Paik, J; DePinho, RA; Sadoshima, J,期刊:Circulation Research, 页码:1470-+ , 文章类型: Article,,卷期:2010年107-12]
- Rationale: Autophagy, a bulk degradation process of cytosolic proteins and organelles, is protective during nutrient starvation in cardiomyocytes (CMs). However, the underlying signaling mechanism mediating autophagy is ...
- In the RyR2(R4496C) Mouse Model of CPVT, beta-Adrenergic Stimulation Induces Ca Waves by Increasing SR Ca Content and Not by Decreasing the Threshold for Ca Waves
[作者:Kashimura, T; Briston, SJ; Trafford, AW; Napolitano, C; Priori, SG; Eisner, DA; Venetucci, LA,期刊:Circulation Research, 页码:1483-+ , 文章类型: Article,,卷期:2010年107-12]
- Rationale: Mutations of the ryanodine receptor (RyR) cause catecholaminergic polymorphic ventricular tachycardia (CPVT). These mutations predispose to the generation of Ca waves and delayed afterdepolarizations during ad...
- Interplay Between Heme Oxygenase-1 and the Multifunctional Transcription Factor Yin Yang 1 in the Inhibition of Intimal Hyperplasia
[作者:Beck, K; Wu, BJ; Ni, J; Santiago, FS; Malabanan, KP; Li, C; Wang, YT; Khachigian, LM; Stocker, R,期刊:Circulation Research, 页码:1490-+ , 文章类型: Article,,卷期:2010年107-12]
- Rationale: Induction of heme oxygenase (HO)-1 protects against experimental atherosclerotic diseases, and certain pharmacological HO-1 inducers, like probucol, inhibit the proliferation of vascular smooth muscle cells an...
- A Major Role for hERG in Determining Frequency of Reentry in Neonatal Rat Ventricular Myocyte Monolayer
[作者:Hou, LQ; Deo, M; Furspan, P; Pandit, SV; Mironov, S; Auerbach, DS; Gong, QM; Zhou, ZF; Berenfeld, O; Jalife, J,期刊:Circulation Research, 页码:1503-+ , 文章类型: Article,,卷期:2010年107-12]
- Rationale: The rapid delayed rectifier potassium current, I-Kr, which flows through the human ether-a-go-go-related (hERG) channel, is a major determinant of the shape and duration of the human cardiac action potential (...
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