- T-Tubule Remodeling During Transition From Hypertrophy to Heart Failure
[作者：Wei, S; Guo, A; Chen, BY; Kutschke, W; Xie, YP; Zimmerman, K; Weiss, RM; Anderson, ME; Cheng, HP; Song, LS,期刊：Circulation Research, 页码：520-U163 , 文章类型： Article，,卷期：2010年107-4]
- Rationale: The transverse tubule (T-tubule) system is the ultrastructural substrate for excitation-contraction coupling in ventricular myocytes; T-tubule disorganization and loss are linked to decreased contractility in ...
- Small Molecule Disruption of G beta gamma Signaling Inhibits the Progression of Heart Failure
[作者：Casey, LM; Pistner, AR; Belmonte, SL; Migdalovich, D; Stolpnik, O; Nwakanma, FE; Vorobiof, G; Dunaevsky, O; Matavel, A; Lopes, CMB; Smrcka, AV; Blaxall, BC,期刊：Circulation Research, 页码：532-539 , 文章类型： Article，,卷期：2010年107-4]
- Rationale: Excess signaling through cardiac G beta gamma subunits is an important component of heart failure (HF) pathophysiology. They recruit elevated levels of cytosolic G protein-coupled receptor kinase (GRK) 2 to ag...
- Nitro-Oleic Acid Inhibits Angiotensin II-Induced Hypertension
[作者：Zhang, JF; Villacorta, L; Chang, L; Fan, ZZ; Hamblin, M; Zhu, TQ; Chen, CS; Cole, MP; Schopfer, FJ; Deng, CX; Garcia-Barrio, MT; Feng, YH; Freeman, BA; Chen, YE,期刊：Circulation Research, 页码：540-U200 , 文章类型： Article，,卷期：2010年107-4]
- Rationale: Nitro-oleic acid (OA-NO2) is a bioactive, nitric-oxide derived fatty acid with physiologically relevant vasculoprotective properties in vivo. OA-NO2 exerts cell signaling actions as a result of its strong elec...
- Elastin Haploinsufficiency Results in Progressive Aortic Valve Malformation and Latent Valve Disease in a Mouse Model
[作者：Hinton, RB; Adelman-Brown, J; Witt, S; Krishnamurthy, VK; Osinska, H; Sakthivel, B; James, JF; Li, DY; Narmoneva, DA; Mecham, RP; Benson, DW,期刊：Circulation Research, 页码：549-U220 , 文章类型： Article，,卷期：2010年107-4]
- Rationale: Elastin is a ubiquitous extracellular matrix protein that is highly organized in heart valves and arteries. Because elastic fiber abnormalities are a central feature of degenerative valve disease, we hypothesi...
- Defining a New Paradigm for Human Arrhythmia Syndromes Phenotypic Manifestations of Gene Mutations in Ion Channel- and Transporter-Associated Proteins
[作者：Ackerman, MJ; Mohler, PJ,期刊：Circulation Research, 页码：457-465 , 文章类型： Review，,卷期：2010年107-4]
- Over the past 15 years, gene mutations in cardiac ion channels have been linked to a host of potentially fatal human arrhythmias including long QT syndrome, short QT syndrome, Brugada syndrome, and catechol-aminergic pol...
- Estrogen Inhibits Vascular Calcification via Vascular RANKL System Common Mechanism of Osteoporosis and Vascular Calcification
[作者：Osako, MK; Nakagami, H; Koibuchi, N; Shimizu, H; Nakagami, F; Koriyama, H; Shimamura, M; Miyake, T; Rakugi, H; Morishita, R,期刊：Circulation Research, 页码：466-U57 , 文章类型： Article，,卷期：2010年107-4]
- Rationale: Arterial calcification and osteoporosis are associated in postmenopausal women. RANK (the receptor activator of nuclear factor kappa B), RANKL (RANK ligand), and osteoprotegerin are key proteins in bone metabo...
- PHLPP-1 Negatively Regulates Akt Activity and Survival in the Heart
[作者：Miyamoto, S; Purcell, NH; Smith, JM; Gao, TY; Whittaker, R; Huang, K; Castillo, R; Glembotski, CC; Sussman, MA; Newton, AC; Brown, JH,期刊：Circulation Research, 页码：476-U78 , 文章类型： Article，,卷期：2010年107-4]
- Rationale: The recently discovered PHLPP-1 (PH domain leucine-rich repeat protein phosphatase-1) selectively dephosphorylates Akt at Ser473 and terminates Akt signaling in cancer cells. The regulatory role of PHLPP-1 in ...
- Inhibition of Bone Morphogenetic Proteins Protects Against Atherosclerosis and Vascular Calcification
[作者：Yao, YC; Bennett, BJ; Wang, XP; Rosenfeld, ME; Giachelli, C; Lusis, AJ; Bostrom, KI,期刊：Circulation Research, 页码：485-U102 , 文章类型： Article，,卷期：2010年107-4]
- Rationale: The bone morphogenetic proteins (BMPs), a family of morphogens, have been implicated as mediators of calcification and inflammation in the vascular wall. Objective: To investigate the effect of altered express...
- PPAR gamma Mediates a Direct Antiangiogenic Effect of omega 3-PUFAs in Proliferative Retinopathy
[作者：Stahl, A; Sapieha, P; Connor, KM; SanGiovanni, JP; Chen, J; Aderman, CM; Willett, KL; Krah, NM; Dennison, RJ; Seaward, MR; Guerin, KI; Hua, J; Smith, LEH,期刊：Circulation Research, 页码：495-500 , 文章类型： Article，,卷期：2010年107-4]
- Rationale: Omega3 long-chain polyunsaturated fatty acids (omega 3-PUFAs) are powerful modulators of angiogenesis. However, little is known about the mechanisms governing omega 3-PUFA-dependent attenuation of angiogenesis...
- Deficiency of the NR4A Orphan Nuclear Receptor NOR1 Decreases Monocyte Adhesion and Atherosclerosis
[作者：Zhao, Y; Howatt, DA; Gizard, F; Nomiyama, T; Findeisen, HM; Heywood, EB; Jones, KL; Conneely, OM; Daugherty, A; Bruemmer, D,期刊：Circulation Research, 页码：501-U131 , 文章类型： Article，,卷期：2010年107-4]
- Rationale: The orphan nuclear receptor NOR1 is a member of the evolutionary highly conserved and ligand-independent NR4A subfamily of the nuclear hormone receptor superfamily. Members of this subfamily have been characte...
- Purkinje Cells From RyR2 Mutant Mice Are Highly Arrhythmogenic But Responsive to Targeted Therapy
[作者：Kang, GX; Giovannone, SF; Liu, NA; Liu, FY; Zhang, J; Priori, SG; Fishman, GI,期刊：Circulation Research, 页码：512-U142 , 文章类型： Article，,卷期：2010年107-4]
- Rationale: The Purkinje fiber network has been proposed as the source of arrhythmogenic Ca2+ release events in catecholaminergic polymorphic ventricular tachycardia (CPVT), yet evidence supporting this mechanism at the c...
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