- Involvement of the Brain (Pro)renin Receptor in Cardiovascular Homeostasis
[作者：Shan, ZY; Shi, P; Cuadra, AE; Dong, Y; Lamont, GJ; Li, QH; Seth, DM; Navar, LG; Katovich, MJ; Sumners, C; Raizada, MK,期刊：Circulation Research, 页码：934-+ , 文章类型： Article，,卷期：2010年107-7]
- Rationale: Despite overwhelming evidence of the importance of brain renin-angiotensin system (RAS), the very existence of intrinsic brain RAS remains controversial. Objective: To investigate the hypothesis that the brain...
- Cardiac Small Conductance Ca2+-Activated K+ Channel Subunits Form Heteromultimers via the Coiled-Coil Domains in the C Termini of the Channels
[作者：Tuteja, D; Rafizadeh, S; Timofeyev, V; Wang, SY; Zhang, Z; Li, N; Mateo, RK; Singapuri, A; Young, JN; Knowlton, AA; Chiamvimonvat, N,期刊：Circulation Research, 页码：851-+ , 文章类型： Article，,卷期：2010年107-7]
- Rationale: Ca2+-activated K+ channels are present in a wide variety of cells. We have previously reported the presence of small conductance Ca2+-activated K+ (SK or K-Ca) channels in human and mouse cardiac myocytes that...
- Notch3 Is Critical for Proper Angiogenesis and Mural Cell Investment
[作者：Liu, H; Zhang, WB; Kennard, S; Caldwell, RB; Lilly, B,期刊：Circulation Research, 页码：860-+ , 文章类型： Article，,卷期：2010年107-7]
- Rationale: The heterotypic interactions of endothelial cells and mural cells (smooth muscle cells or pericytes) are crucial for assembly, maturation, and subsequent function of blood vessels. Yet, the molecular mechanism...
- Receptor Activator of Nuclear Factor kappa B Ligand Is a Novel Inducer of Tissue Factor in Macrophages
[作者：Kim, J; Min, JK; Park, JA; Doh, HJ; Choi, YS; Rho, J; Kim, YM; Kwon, YG,期刊：Circulation Research, 页码：871-876 , 文章类型： Article，,卷期：2010年107-7]
- Rationale: Although recent studies have suggested a role for the receptor activator of nuclear factor kappa B ligand (RANKL) in the late stages of atherosclerosis (eg, plaque destabilization and rupture), the underlying ...
- Histone Deacetylase 3 Antagonizes Aspirin-Stimulated Endothelial Nitric Oxide Production by Reversing Aspirin-Induced Lysine Acetylation of Endothelial Nitric Oxide Synthase
[作者：Jung, SB; Kim, CS; Naqvi, A; Yamamori, T; Mattagajasingh, I; Hoffman, TA; Cole, MP; Kumar, A; DeRicco, JS; Jeon, BH; Irani, K,期刊：Circulation Research, 页码：877-+ , 文章类型： Article，,卷期：2010年107-7]
- Rationale: Low-dose acetylsalicylic acid (aspirin) is widely used in the treatment and prevention of vascular atherothrombosis. Cardiovascular doses of aspirin also reduce systemic blood pressure and improve endothelium-...
- Genetic Ace2 Deficiency Accentuates Vascular Inflammation and Atherosclerosis in the ApoE Knockout Mouse
[作者：Thomas, MC; Pickering, RJ; Tsorotes, D; Koitka, A; Sheehy, K; Bernardi, S; Toffoli, B; Nguyen-Huu, TP; Head, GA; Fu, Y; Chin-Dusting, J; Cooper, ME; Tikellis, C,期刊：Circulation Research, 页码：888-+ , 文章类型： Article，,卷期：2010年107-7]
- Rationale: Angiotensin-converting enzyme (ACE)2 opposes the actions of angiotensin (Ang) II by degrading it to Ang 1-7. Objective: Given the important role of Ang II/Ang 1-7 in atherogenesis, we investigated the impact o...
- Zyxin Mediation of Stretch-Induced Gene Expression in Human Endothelial Cells
[作者：Wojtowicz, A; Babu, SS; Li, L; Gretz, N; Hecker, M; Cattaruzza, M,期刊：Circulation Research, 页码：898-+ , 文章类型： Article，,卷期：2010年107-7]
- Rationale: Prolonged exposure to enhanced stretch, such as in hypertension, triggers endothelial dysfunction, a hallmark of pathological vascular remodeling processes. Despite its clinical relevance, little is known abou...
- Receptor-Independent Cardiac Protein Kinase C alpha Activation by Calpain-Mediated Truncation of Regulatory Domains
[作者：Kang, MY; Zhang, Y; Matkovich, SJ; Diwan, A; Chishti, AH; Dorn, GW,期刊：Circulation Research, 页码：903-912 , 文章类型： Article，,卷期：2010年107-7]
- Rationale: Protein kinase (PK)Cs and calpain cysteine proteases are highly expressed in myocardium. Ischemia produces calcium overload that activates calpains and conventional PKCs. However, calpains can proteolytically ...
- Bone Marrow Mesenchymal Stem Cells Stimulate Cardiac Stem Cell Proliferation and Differentiation
[作者：Hatzistergos, KE; Quevedo, H; Oskouei, BN; Hu, QH; Feigenbaum, GS; Margitich, IS; Mazhari, R; Boyle, AJ; Zambrano, JP; Rodriguez, JE; Dulce, R; Pattany, PM; Valdes, D; Revilla, C; Heldman, AW; McNiece, I; Hare, JM,期刊：Circulation Research, 页码：913-+ , 文章类型： Article，,卷期：2010年107-7]
- Rationale: The regenerative potential of the heart is insufficient to fully restore functioning myocardium after injury, motivating the quest for a cell-based replacement strategy. Bone marrow-derived mesenchymal stem ce...
- Sphingosine-1-Phosphate-Dependent Activation of p38 MAPK Maintains Elevated Peripheral Resistance in Heart Failure Through Increased Myogenic Vasoconstriction
[作者：Hoefer, J; Azam, MA; Kroetsch, JTE; Leong-Poi, H; Momen, MA; Voigtlaender-Bolz, J; Scherer, EQ; Meissner, A; Bolz, SS; Husain, M,期刊：Circulation Research, 页码：923-+ , 文章类型： Article，,卷期：2010年107-7]
- Rationale: Mechanisms underlying vasomotor abnormalities and increased peripheral resistance exacerbating heart failure (HF) are poorly understood. Objective: To explore the role and molecular basis of myogenic responses...
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