- Biology of Endoplasmic Reticulum Stress in the Heart
[作者:Groenendyk, J; Sreenivasaiah, PK; Kim, DH; Agellon, LB; Michalak, M,期刊:Circulation Research, 页码:1185-1197 , 文章类型: Review,,卷期:2010年107-10]
- The endoplasmic reticulum (ER) is a multifunctional intracellular organelle supporting many processes required by virtually every mammalian cell, including cardiomyocytes. It performs diverse functions, including protein...
- Collagen XV Is Necessary for Modeling of the Extracellular Matrix and Its Deficiency Predisposes to Cardiomyopathy
[作者:Rasi, K; Piuhola, J; Czabanka, M; Sormunen, R; Ilves, M; Leskinen, H; Rysa, J; Kerkela, R; Janmey, P; Heljasvaara, R; Peuhkurinen, K; Vuolteenaho, O; Ruskoaho, H; Vajkoczy, P; Pihlajaniemi, T; Eklund, L,期刊:Circulation Research, 页码:1241-1252 , 文章类型: Article,,卷期:2010年107-10]
- Rationale: The extracellular matrix (ECM) is a major determinant of the structural integrity and functional properties of the myocardium in common pathological conditions, and changes in vasculature contribute to cardiac...
- Myomasp/LRRC39, a Heart- and Muscle-Specific Protein, Is a Novel Component of the Sarcomeric M-Band and Is Involved in Stretch Sensing
[作者:Will, RD; Eden, M; Just, S; Hansen, A; Eder, A; Frank, D; Kuhn, C; Seeger, TS; Oehl, U; Wiemann, S; Korn, B; Koegl, M; Rottbauer, W; Eschenhagen, T; Katus, HA; Frey, N,期刊:Circulation Research, 页码:1253-1264 , 文章类型: Article,,卷期:2010年107-10]
- Rationale and Objective: The M-band represents a transverse structure in the center of the sarcomeric A-band and provides an anchor for the myosin-containing thick filaments. In contrast to other sarcomeric structures, e...
- The Mechanical Stress-Activated Serum-, Glucocorticoid-Regulated Kinase 1 Contributes to Neointima Formation in Vein Grafts
[作者:Cheng, JZ; Wang, Y; Ma, YW; Chan, BTY; Yang, M; Liang, AL; Zhang, LP; Li, HH; Du, J,期刊:Circulation Research, 页码:1265-1274 , 文章类型: Article,,卷期:2010年107-10]
- Rationale: Mechanical stress plays an important role in proliferation of venous smooth muscle cells (SMCs) in neointima, a process of formation that contributes to failure of vein grafts. However, it is unknown what intr...
- Loss of PI3K gamma Enhances cAMP-Dependent MMP Remodeling of the Myocardial N-Cadherin Adhesion Complexes and Extracellular Matrix in Response to Early Biomechanical Stress
[作者:Guo, D; Kassiri, Z; Basu, R; Chow, FL; Kandalam, V; Damilano, F; Liang, WB; Izumo, S; Hirsch, E; Penninger, JM; Backx, PH; Oudit, GY,期刊:Circulation Research, 页码:1275-1289 , 文章类型: Article,,卷期:2010年107-10]
- Rationale: Mechanotransduction and the response to biomechanical stress is a fundamental response in heart disease. Loss of phosphoinositide 3-kinase (PI3K)gamma, the isoform linked to G protein-coupled receptor signalin...
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