- Decreased S-Nitrosylation of Tissue Transglutaminase Contributes to Age-Related Increases in Vascular Stiffness
[作者：Santhanam, L; Tuday, EC; Webb, AK; Dowzicky, P; Kim, JH; Oh, YJ; Sikka, G; Kuo, M; Halushka, MK; Macgregor, AM; Dunn, J; Gutbrod, S; Yin, D; Shoukas, A; Nyhan, D; Flavahan, NA; Belkin, AM; Berkowitz, DE,期刊：Circulation Research, 页码：117-117 , 文章类型： Article，,卷期：2010年107-1]
- Rationale: Although an age-related decrease in NO bioavailability contributes to vascular stiffness, the underlying molecular mechanisms remain incompletely understood. We hypothesize that NO constrains the activity of t...
- Mechanistic Links Between Na+ Channel (SCN5A) Mutations and Impaired Cardiac Pacemaking in Sick Sinus Syndrome
[作者：Butters, TD; Aslanidi, OV; Inada, S; Boyett, MR; Hancox, JC; Lei, M; Zhang, HG,期刊：Circulation Research, 页码：126-126 , 文章类型： Article，,卷期：2010年107-1]
- Rationale: Familial sick sinus syndrome (SSS) has been linked to loss-of-function mutations of the SCN5A gene, which result in decreased inward Na+ current, I-Na. However, the functional role of I-Na in cardiac pacemakin...
- Asymmetric Dimethylarginine Impairs Angiogenic Progenitor Cell Function in Patients With Coronary Artery Disease Through a MicroRNA-21-Dependent Mechanism
[作者：Fleissner, F; Jazbutyte, V; Fiedler, J; Gupta, SK; Yin, XK; Xu, QB; Galuppo, P; Kneitz, S; Mayr, M; Ertl, G; Bauersachs, J; Thum, T,期刊：Circulation Research, 页码：138-138 , 文章类型： Article，,卷期：2010年107-1]
- Rationale: The endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) is increased in patients with coronary artery disease and may regulate function of circulating angiogenic progenitor cells (A...
- Effects of Chronic Atrial Fibrillation on Active and Passive Force Generation in Human Atrial Myofibrils
[作者：Belus, A; Piroddi, N; Ferrantini, C; Tesi, C; Cazorla, O; Toniolo, L; Drost, M; Mearini, G; Carrier, L; Rossi, A; Mugelli, A; Cerbai, E; van der Velden, J; Poggesi, C,期刊：Circulation Research, 页码：144-144 , 文章类型： Article，,卷期：2010年107-1]
- Rationale: Chronic atrial fibrillation (cAF) is associated with atrial contractile dysfunction. Sarcomere remodeling may contribute to this contractile disorder. Objective: Here, we use single atrial myofibrils and fast ...
- Biphasic Development of the Mammalian Ventricular Conduction System
[作者：Miquerol, L; Moreno-Rascon, N; Beyer, S; Dupays, L; Meilhac, SM; Buckingham, ME; Franco, D; Kelly, RG,期刊：Circulation Research, 页码：153-153 , 文章类型： Article，,卷期：2010年107-1]
- Rationale: The ventricular conduction system controls the propagation of electric activity through the heart to coordinate cardiac contraction. This system is composed of specialized cardiomyocytes organized in defined s...
- The (Pro)renin Receptor/ATP6AP2 is Essential for Vacuolar H+-ATPase Assembly in Murine Cardiomyocytes
[作者：Kinouchi, K; Ichihara, A; Sano, M; Sun-Wada, GH; Wada, Y; Kurauchi-Mito, A; Bokuda, K; Narita, T; Oshima, Y; Sakoda, M; Tamai, Y; Sato, H; Fukuda, K; Itoh, H,期刊：Circulation Research, 页码：30-34 , 文章类型： Article，,卷期：2010年107-1]
- Rationale: The (pro) renin receptor [(P)RR], encoded in ATP6AP2, plays a key role in the activation of local renin-angiotensin system (RAS). A truncated form of (P) RR, termed M8.9, was also found to be associated with t...
- Development of a Drug Screening Platform Based on Engineered Heart Tissue
[作者：Hansen, A; Eder, A; Bonstrup, M; Flato, M; Mewe, M; Schaaf, S; Aksehirlioglu, B; Schworer, A; Uebeler, J; Eschenhagen, T,期刊：Circulation Research, 页码：35-35 , 文章类型： Article，,卷期：2010年107-1]
- Rationale: Tissue engineering may provide advanced in vitro models for drug testing and, in combination with recent induced pluripotent stem cell technology, disease modeling, but available techniques are unsuitable for ...
- The Rac1 Regulator ELMO1 Controls Vascular Morphogenesis in Zebrafish
[作者：Epting, D; Wendik, B; Bennewitz, K; Dietz, CT; Driever, W; Kroll, J,期刊：Circulation Research, 页码：45-45 , 文章类型： Article，,卷期：2010年107-1]
- Rationale: Angiogenesis is regulated by the small GTPase Rac1. The ELMO1/DOCK180 complex forms a guanine nucleotide exchange factor for Rac1, regulating its activation during cell migration in different biological system...
- Low Doses of Lipopolysaccharide and Minimally Oxidized Low-Density Lipoprotein Cooperatively Activate Macrophages via Nuclear Factor kappa B and Activator Protein-1 Possible Mechanism for Acceleration of Atherosclerosis by Subclinical Endotoxemia
[作者：Wiesner, P; Choi, SH; Almazan, F; Benner, C; Huang, W; Diehl, CJ; Gonen, A; Butler, S; Witztum, JL; Glass, CK; Miller, YI,期刊：Circulation Research, 页码：56-65 , 文章类型： Article，,卷期：2010年107-1]
- Rationale: Oxidized low-density lipoprotein (LDL) is an important determinant of inflammation in atherosclerotic lesions. It has also been documented that certain chronic infectious diseases, such as periodontitis and ch...
- CD146 Short Isoform Increases the Proangiogenic Potential of Endothelial Progenitor Cells In Vitro and In Vivo
[作者：Kebir, A; Harhouri, K; Guillet, B; Liu, JW; Foucault-Bertaud, A; Lamy, E; Kaspi, E; Elganfoud, N; Vely, F; Sabatier, F; Sampol, J; Pisano, P; Kruithof, EKO; Bardin, N; Dignat-George, F; Blot-Chabaud, M,期刊：Circulation Research, 页码：66-66 , 文章类型： Article，,卷期：2010年107-1]
- Rationale: CD146, a transmembrane immunoglobulin mainly expressed at the intercellular junction of endothelial cells, is involved in cell-cell cohesion, paracellular permeability, monocyte transmigration and angiogenesis...
- Cardioprotection of Ischemia/Reperfusion Injury by Cholesterol-Dependent MG53-Mediated Membrane Repair
[作者：Wang, XH; Xie, WJ; Zhang, Y; Lin, PH; Han, LA; Han, PD; Wang, YR; Chen, Z; Ji, GJ; Zheng, M; Weisleder, N; Xiao, RP; Takeshima, H; Ma, JJ; Cheng, HP,期刊：Circulation Research, 页码：76-76 , 文章类型： Article，,卷期：2010年107-1]
- Rationale: Unrepaired cardiomyocyte membrane injury causes irreplaceable cell loss, leading to myocardial fibrosis and eventually heart failure. However, the cellular and molecular mechanisms of cardiac membrane repair a...
- EH Domain Proteins Regulate Cardiac Membrane Protein Targeting
[作者：Gudmundsson, H; Hund, TJ; Wright, PJ; Kline, CF; Snyder, JS; Qian, L; Koval, OM; Cunha, SR; George, M; Rainey, MA; Kashef, FE; Dun, W; Boyden, PA; Anderson, ME; Band, H; Mohler, PJ,期刊：Circulation Research, 页码：84-84 , 文章类型： Article，,卷期：2010年107-1]
- Rationale: Cardiac membrane excitability is tightly regulated by an integrated network of membrane-associated ion channels, transporters, receptors, and signaling molecules. Membrane protein dynamics in health and diseas...
|