- Bovine Pancreatic Ribonuclease: Fifty Years of the First Enzymatic Reaction Mechanism
[作者:Cuchillo, CM; Nogues, MV; Raines, RT,期刊:Biochemistry, 页码:7835-7841 , 文章类型: Article,,卷期:2011年50-37]
- Fifty years ago, the group of Tony Mathias and Bob Rabin at University College London deduced the first mechanism for catalysis by an enzyme, ribonuclease [Findlay, D., Herries, D. G., Mathias, A. P., Rabin, B. R., and R...
- When Galectins Recognize Glycans: From Biochemistry to Physiology and Back Again
[作者:Di Lella, S; Sundblad, V; Cerliani, JP; Guardia, CM; Estrin, DA; Vasta, GR; Rabinovich, GA,期刊:Biochemistry, 页码:7842-7857 , 文章类型: Article,,卷期:2011年50-37]
- In the past decade, increasing efforts have been devoted to the study of galectins, a family of evolutionarily conserved glycan-binding proteins with multifunctional properties. Galectins function, either intracellularly...
- Identification of Proline Residues in or near the Transmembrane Helices of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) That Are Important for Transport Activity and Substrate Specificity
[作者:Ni, ZL; Bikadi, Z; Shuster, DL; Zhao, CS; Rosenberg, MF; Mao, QC,期刊:Biochemistry, 页码:8057-8066 , 文章类型: Article,,卷期:2011年50-37]
- The human breast cancer resistance protein (BCRP/ABCG2) confers multidrug resistance and mediates the active efflux of drugs and xenobiotics. BCRP contains one nucleotide-binding domain (NBD) followed by one membrane-spa...
- The Glutamine Side Chain at Position 91 on the beta 5a-beta 5b Loop of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Is Required for Stabilizing the dNTP Binding Pocket
[作者:Pandey, N; Mishra, CA; Manvar, D; Upadhyay, AK; Talele, TT; Comollo, TW; Kaushik-Basu, N; Pandey, VN,期刊:Biochemistry, 页码:8067-8077 , 文章类型: Article,,卷期:2011年50-37]
- Earlier, we postulated that Gln91 of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) stabilizes the side chain of Tyr183 via hydrogen bonding interaction between 0(H) of Tyr183 and CO of Q91 [Harris,...
- A Blue Corrinoid from Partial Degradation of Vitamin B(12) in Aqueous Bicarbonate: Spectra, Structure, and Interaction with Proteins of B(12) Transport
[作者:Fedosov, SN; Ruetz, M; Gruber, K; Fedosova, NU; Krautler, B,期刊:Biochemistry, 页码:8090-8101 , 文章类型: Article,,卷期:2011年50-37]
- Cobalarnin (Cbl) is a complex cofactor produced only by bacteria but used by all animals and humans. Cyanocobalamin (vitamin B(12), CNCb1) is one commonly isolated form of cobalamin. B12 belongs to a large group of corri...
- Self-Assembly of Escherichia coli MutL and Its Complexes with DNA
[作者:Niedziela-Majka, A; Maluf, NK; Antony, E; Lohman, TM,期刊:Biochemistry, 页码:7868-7880 , 文章类型: Article,,卷期:2011年50-37]
- The Escherichia coil MutL protein regulates the activity of several enzymes, including MutS, MutH, and UvrD, during methyl-directed mismatch repair of DNA. We have investigated the self-association properties of MutL and...
- Design and Characterization of Stabilized Derivatives of Human CD4D12 and CD4D1
[作者:Saha, P; Barua, B; Bhattacharyya, S; Balamurali, MM; Schief, WR; Baker, D; Varadarajan, R,期刊:Biochemistry, 页码:7891-7900 , 文章类型: Article,,卷期:2011年50-37]
- CD4 is present on the surface of T-lymphocytes and is the primary cellular receptor for HIV-1. CD4 consists of a cytoplasmic tail, one transmembrane region, and four extracellular domains, D1-D4. A construct consisting o...
- Proline in Transmembrane Domain of Type II Protein DPP-IV Governs Its Translocation Behavior through Endoplasmic Reticulum
[作者:Chung, KM; Huang, CH; Cheng, JH; Tsai, CH; Suen, CS; Hwang, MJ; Chen, X,期刊:Biochemistry, 页码:7909-7918 , 文章类型: Article,,卷期:2011年50-37]
- A transmembrane domain (TMD) at the N-terminus of a membrane protein is a signal sequence that targets the protein to the endoplasmic reticulum (ER) membrane. Pro line is found more frequently in TM helices compared to w...
- What Determines the Activity of Antimicrobial and Cytolytic Peptides in Model Membranes
[作者:Clark, KS; Svetlovics, J; McKeown, AN; Huskins, L; Almeida, PF,期刊:Biochemistry, 页码:7919-7932 , 文章类型: Article,,卷期:2011年50-37]
- We previously proposed three hypotheses relating the mechanism of antimicrobial and cytolytic peptides in model membranes to the Gibbs free energies of binding and insertion into the membrane [Almeida, P. F., and Pokorny...
- Relationship between Conformational Stability and Amplification Efficiency of Prions
[作者:Gonzalez-Montalban, N; Makarava, N; Savtchenko, R; Baskakov, IV,期刊:Biochemistry, 页码:7933-7940 , 文章类型: Article,,卷期:2011年50-37]
- Recent studies demonstrated that the efficiency, rate, and yield of prion amplification in vitro could be substantially improved by supplementing protein misfolding cyclic amplification (PMCA) with Teflon beads [Gonzalez...
|