- Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation
[作者:Sriram, G; Reichman, C; Tunceroglu, A; Kaushal, N; Saleh, T; Machida, K; Mayer, B; Ge, Q; Li, J; Hornbeck, P; Kalodimos, CG; Birge, RB,期刊:Oncogene, 页码:4645-4655 , 文章类型: Article,,卷期:2011年30-46]
- Here, we report the identification and characterization of a novel tyrosine phosphorylation site in the carboxyterminal Src Homology 3 (SH3) (SH3C) domain of the Crk adaptor protein. Y251 is located in the highly conserv...
- TP63 P2 promoter functional analysis identifies beta-catenin as a key regulator of Delta Np63 expression
[作者:Ruptier, C; De Gasperis, A; Ansieau, S; Granjon, A; Taniere, P; Lafosse, I; Shi, H; Petitjean, A; Taranchon-Clermont, E; Tribollet, V; Voeltzel, T; Scoazec, JY; Maguer-Satta, V; Puisieux, A; Hainaut, P; Cavard, C; de Fromentel, CC,期刊:Oncogene, 页码:4656-4665 , 文章类型: Article,,卷期:2011年30-46]
- The Delta Np63 protein, a product of the TP63 gene that lacks the N-terminal domain, has a critical role in the maintenance of self renewal and progenitor capacity in several types of epithelial tissues. Delta Np63 is fr...
- Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma
[作者:Watt, SA; Pourreyron, C; Purdie, K; Hogan, C; Cole, CL; Foster, N; Pratt, N; Bourdon, JC; Appleyard, V; Murray, K; Thompson, AM; Mao, X; Mein, C; Bruckner-Tuderman, L; Evans, A; McGrath, JA; Proby, CM; Foerster, J; Leigh, IM; South, AP,期刊:Oncogene, 页码:4666-4677 , 文章类型: Article,,卷期:2011年30-46]
- Identifying therapeutic targets for cancer treatment relies on consistent changes within particular types or sub-types of malignancy. The ability to define either consistent changes or sub-types of malignancy is often ma...
- Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating-cancer stem cells: distinct, overlapping or same populations
[作者:Floor, S; van Staveren, WCG; Larsimont, D; Dumont, JE; Maenhaut, C,期刊:Oncogene, 页码:4609-4621 , 文章类型: Review,,卷期:2011年30-46]
- Cell populations of solid cancers and their distant models, the cancer cell lines, have been categorized in sub-populations: cancer stem-tumor-propagating cells (CSC-TPC) versus derived cells, epithelial-versus mesenchym...
- Evidence for the transmission of neoplastic properties from transformed to normal human stem cells
[作者:Werbowetski-Ogilvie, TE; Schnerch, A; Rampalli, S; Mills, CE; Lee, JB; Hong, SH; Levadoux-Martin, M; Bhatia, M,期刊:Oncogene, 页码:4632-4644 , 文章类型: Article,,卷期:2011年30-46]
- The in vivo relationship between human tumor cells and interacting normal cells in their local environment is poorly understood. Here, using a uniquely developed in vitro co-culture system for human embryonic stem cells ...
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