- Alternative Splicing: A Promising Target for Pharmaceutical Inhibition of Pathological Angiogenesis?
[作者:Munaut, C; Colige, AC; Lambert, CA,期刊:Current Pharmaceutical Design, 页码:3864-3876 , 文章类型: Review,,卷期:2010年16-35]
- In eukaryotes, genes consist in coding sequences (exons) interspersed with non-coding ones (introns). The regulation of alternative inclusion/exclusion of exons, or part of exons, during the maturation of the pre-mRNA in...
- Insulin, Thrombin, ERK1/2 Kinase and Vascular Smooth Muscle Cells Proliferation
[作者:Isenovic, ER; Soskic, S; Trpkovic, A; Dobutovic, B; Popovic, M; Gluvic, Z; Putnikovic, B; Marche, P,期刊:Current Pharmaceutical Design, 页码:3895-3902 , 文章类型: Review,,卷期:2010年16-35]
- Vascular smooth muscle cells (VSMC) respond to arterial wall injury by intimal proliferation and play a key role in atherogenesis by proliferating and migrating excessively in response to repeated injury, such as hyperte...
- Do Not Say Ever Never More: The Ins and Outs of Antiangiogenic Therapies
[作者:Quesada, AR; Medina, MA; Munoz-Chapuli, R; Ponce, ALG,期刊:Current Pharmaceutical Design, 页码:3932-3957 , 文章类型: Review,,卷期:2010年16-35]
- Angiogenesis has been described as one of the hallmarks of cancer, playing an essential role in tumor growth, invasion, and metastasis. Antiangiogenic therapy was initially perceived as a "magic bullet" that could eventu...
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