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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共15条记录   Antimicrobial Peptides and Peptaibols, Substitutes for Conventional Antibiotics [作者：Duclohier, H,期刊：Current Pharmaceutical Design, 页码：3212-3223 , 文章类型： Review，,卷期：2010年16-28] In this review, the antimicrobial properties of a number of peptides are described. We first deal with helical linear peptides such as the well-known gramicidin, magainins, melittin, and other less well-known or more rec... Optimization and High-Throughput Screening of Antimicrobial Peptides [作者：Blondelle, SE; Lohner, K,期刊：Current Pharmaceutical Design, 页码：3204-3211 , 文章类型： Review，,卷期：2010年16-28] While a well-established process for lead compound discovery in for-profit companies, high-throughput screening is becoming more popular in basic and applied research settings in academia. The development of combinatoria... Synthetic Peptides Derived from the C-Terminal Region of Lys49 Phospholipase A(2) Homologues from Viperidae Snake Venoms: Biomimetic Activities and Potential Applications [作者：Lomonte, B; Angulo, Y; Moreno, E,期刊：Current Pharmaceutical Design, 页码：3224-3230 , 文章类型： Review，,卷期：2010年16-28] Lys49-phospholipase A(2) homologues constitute a large family of toxins present in the venoms of viperid snake species, which despite lacking catalytic activity, cause significant skeletal muscle necrosis. The main struc... Therapeutic Potential of Peptide Motifs - Part IV [作者：Herve, JC,期刊：Current Pharmaceutical Design, 页码：3053-3055 , 文章类型： Editorial Material，,卷期：2010年16-28] Peptidomimetic Competitive Inhibitors of Protein Tyrosine Phosphatases [作者：Shen, K; Qi, LX; Stiff, L,期刊：Current Pharmaceutical Design, 页码：3101-3117 , 文章类型： Review，,卷期：2010年16-28] This review discusses the development of the active site-directed protein tyrosine phosphatase (PTP) inhibitors based on peptides and some closely related nonpeptidic scaffolds. A straightforward approach is to substitut... Peptides Targeting Gap Junctional Structures [作者：Herve, JC; Dhein, S,期刊：Current Pharmaceutical Design, 页码：3056-3070 , 文章类型： Review，,卷期：2010年16-28] Cells of multicellular organisms need to communicate and have evolved different mechanisms of intercellular communication, the most direct and quickest of which is through channels that directly link the cytoplasms of ad... Gene Targeting and Expression Modulation by Peptide Nucleic Acids (PNA) [作者：Nielsen, PE,期刊：Current Pharmaceutical Design, 页码：3118-3123 , 文章类型： Review，,卷期：2010年16-28] Peptide nucleic acids (PNA) are artificial structural mimics of nucleic acids capable of sequence specific hybridization to both RNA and DNA. Thus they have obvious potential as gene targeting agents for drug discovery a... Bcl-2 Family Proteins as Therapeutic Targets [作者：Czabotar, PE; Lessene, G,期刊：Current Pharmaceutical Design, 页码：3132-3148 , 文章类型： Review，,卷期：2010年16-28] The mitochondrion provides the stage for the interplay of molecular interactions that regulate apoptosis via the intrinsic pathway. The release of apoptogenic factors from this compartment constitutes a critical juncture... Neuropeptides as Therapeutic Approach to Autoimmune Diseases [作者：Gonzalez-Rey, E; Delgado-Maroto, V; Souza-Moreira, L; Delgado, M,期刊：Current Pharmaceutical Design, 页码：3158-3172 , 文章类型： Review，,卷期：2010年16-28] Because there are no particular molecular signatures of self, autoimmunity is the inevitable evolutionary price of being able to make effective responses against a wide variety of pathogens by the immune system. Without ... Epitope Discovery and Their Use in Peptide Based Vaccines [作者：Dudek, NL; Perlmutter, P; Aguilar, MI; Croft, NP; Purcell, AW,期刊：Current Pharmaceutical Design, 页码：3149-3157 , 文章类型： Review，,卷期：2010年16-28] With recent advances in the design and delivery of peptide-based therapeutics there has been a growing interest in the use of peptides in vaccine design. Moreover, functional dissection and proteomic analysis of the immu... Chemical Modifications Designed to Improve Peptide Stability: Incorporation of Non-Natural Amino Acids, Pseudo-Peptide Bonds, and Cyclization [作者：Gentilucci, L; De Marco, R; Cerisoli, L,期刊：Current Pharmaceutical Design, 页码：3185-3203 , 文章类型： Review，,卷期：2010年16-28] Functions and properties of native peptides vary from highly specific antibiotics or cytotoxic antitumor drugs, to hormones, neurotransmitters, immunomodulators, etc. Despite their potential utility as therapeutic agents... HDL Apolipoprotein-Related Peptides in the Treatment of Atherosclerosis and other Inflammatory Disorders [作者：Getz, GS; Wool, GD; Reardon, CA,期刊：Current Pharmaceutical Design, 页码：3173-3184 , 文章类型： Review，,卷期：2010年16-28] Elevations of HDL levels or modifying the inflammatory properties of HDL are being evaluated as possible treatment of atherosclerosis, the underlying mechanism responsible for most cardiovascular diseases. A promising ap... Ligand-Based Peptide Design and Combinatorial Peptide Libraries to Target G Protein-Coupled Receptors [作者：Gruber, CW; Muttenthaler, M; Freissmuth, M,期刊：Current Pharmaceutical Design, 页码：3071-3088 , 文章类型： Review，,卷期：2010年16-28] G protein-coupled receptors (GPCRs) are considered to represent the most promising drug targets; it has been repeatedly said that a large fraction of the currently marketed drugs elicit their actions by binding to GPCRs ... Mitochondria-Targeted Antioxidant Peptides [作者：Rocha, M; Hernandez-Mijares, A; Garcia-Malpartida, K; Banuls, C; Bellod, L; Victor, VM,期刊：Current Pharmaceutical Design, 页码：3124-3131 , 文章类型： Review，,卷期：2010年16-28] Overproduction of reactive oxygen species (ROS) under pathophysiologic conditions is part of the disease process. These ROS are released from different sources, and in particular from mitochondria. Although the molecular... Orexins/Hypocretins: Pain Regulation and Cellular Actions [作者：Chiou, LC; Lee, HJ; Ho, YC; Chen, SP; Liao, YY; Ma, CH; Fan, PC; Fuh, JL; Wang, SJ,期刊：Current Pharmaceutical Design, 页码：3089-3100 , 文章类型： Review，,卷期：2010年16-28] Orexin A and B (also named hypocretin 1 and 2) are 33 and 28 amino acid-containing neuropeptides, respectively, derived from prepro-orexin (prepro-hypocretin) which is localized in the lateral and perifonical areas of th...