- (1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carb oxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans
[作者:BOATMAN P DOUGLAS; LAURING BRETT; SCHRADER THOMAS O; KASEM MICHELLE; JOHNSON BENJAMIN R; SKINNER PHILIP; JUNG JAEKYU; XU JERRY; CHERRIER MARTIN C; WEBB PETER J; SEMPLE GRAEME; SAGE CARLETON R; KNUDSEN JENS; CHEN RUOPING; LUO WENLIN; CARO LUZELENA; COTE JOSEE; LAI ESENG; WAGNER JOHN; TAGGART ANDREW K; CARBALLOJANE ESTER; HAMMOND MILTON; COLLETTI STEVEN L; TATA JAMES R; CONNOLLY DANIEL T; WATERS M GERARD; RICHMAN JEREMY G,期刊:Journal of Medicinal Chemistry, 页码:3644-3666 , 文章类型: Article,,卷期:2012年55-8]
- G-protein coupled receptor (GPCR) GPR109a is a molecular target for nicotinic acid and is expressed in adipocytes, spleen, and immune cells. Nicotinic acid has long been used for the treatment of dyslipidemia due to its ...
- Beyond Size, Ionization State, and Lipophilicity: Influence of Molecular Topology on Absorption, Distribution, Metabolism, Excretion, and Toxicity for Druglike Compounds
[作者:YANG YIDONG; ENGKVIST OLA; LLINAS ANTONIO; CHEN HONGMING,期刊:Journal of Medicinal Chemistry, 页码:3667-3677 , 文章类型: Article,,卷期:2012年55-8]
- The absorption, distribution, metabolism, excretion, and toxicity (ADMET) of a compound is dependent on physicochemical properties such as molecular size, lipophilicity, and ionization state. However, much less is known ...
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