- Factors determining antibody distribution in tumors
[作者:Thurber, GM; Schmidt, MM; Wittrup, KD,期刊:Trends in Pharmacological Sciences, 页码:57-61 , 文章类型: Review,,卷期:2008年29-2]
The development of antibody therapies for cancer is increasing rapidly, primarily owing to their specificity. Antibody distribution in tumors is often extremely uneven, however, leading to some malignant cells being e...
- What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases
[作者:Evans, JF; Ferguson, AD; Mosley, RT; Hutchinson, JH,期刊:Trends in Pharmacological Sciences, 页码:72-78 , 文章类型: Review,,卷期:2008年29-2]
Leukotrienes have physiological roles in innate immune responses and pathological roles in inflammatory diseases, such as asthma, allergic rhinitis and atherosclerosis. Anti-leukotriene therapy has proven benefits in ...
- Functional neuroimaging in schizophrenia: diagnosis and drug discovery
[作者:McGuire, P; Howes, OD; Stone, J; Fusar-Poli, P,期刊:Trends in Pharmacological Sciences, 页码:91-98 , 文章类型: Review,,卷期:2008年29-2]
Functional neuroimaging provides a direct way of investigating the pathophysiology of schizophrenia in vivo. The function of neurotransmitters implicated in schizophrenia, such as dopamine and glutamate, can be assess...
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