- Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome
[作者：De Vita, S; Canzonetta, C; Mulligan, C; Delom, F; Groet, J; Baldo, C; Vanes, L; Dagna-Bricarelli, F; Hoischen, A; Veltman, J; Fisher, EMC; Tybulewicz, VLJ; Nizetic, D,期刊：Oncogene, 页码：6102-6114 , 文章类型： Article，,卷期：2010年29-46]
- Children with Down's syndrome (DS) have 20-50-fold higher incidence of all leukaemias (lymphoid and myeloid), for reasons not understood. As incidence of many solid tumours is much lower in DS, we speculated that disturb...
- Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population
[作者：Fukunaga-Kalabis, M; Martinez, G; Nguyen, TK; Kim, D; Santiago-Walker, A; Roesch, A; Herlyn, M,期刊：Oncogene, 页码：6115-6124 , 文章类型： Article，,卷期：2010年29-46]
- Tenascin-C (TNC) is highly expressed in melanoma; however, little is known about its functions. Recent studies indicate that TNC has a role within the stem cell niche. We hypothesized that TNC creates a specific environm...
- Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair
[作者：Tian, L; Peng, G; Parant, JM; Leventaki, V; Drakos, E; Zhang, Q; Parker-Thornburg, J; Shackleford, TJ; Dai, H; Lin, SY; Lozano, G; Rassidakis, GZ; Claret, FX,期刊：Oncogene, 页码：6125-6137 , 文章类型： Article，,卷期：2010年29-46]
- Jun activation domain-binding protein 1 (JAB1) is a multifunctional protein that participates in the control of cell proliferation and the stability of multiple proteins. JAB1 overexpression has been implicated in the pa...
- The CASPR2 cell adhesion molecule functions as a tumor suppressor gene in glioma
[作者：Bralten, LBC; Gravendeel, AM; Kloosterhof, NK; Sacchetti, A; Vrijenhoek, T; Veltman, JA; van den Bent, MJ; Kros, JM; Hoogenraad, CC; Smitt, PAES; French, PJ,期刊：Oncogene, 页码：6138-6148 , 文章类型： Article，,卷期：2010年29-46]
- Genomic translocations have been implicated in cancer. In this study, we performed a screen for genetic translocations in gliomas based on exon-level expression profiles. We identified a translocation in the contactin-as...
- YAP dysregulation by phosphorylation or Delta Np63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets
[作者：Ehsanian, R; Brown, M; Lu, H; Yang, XP; Pattatheyil, A; Yan, B; Duggal, P; Chuang, R; Doondeea, J; Feller, S; Sudol, M; Chen, Z; Van Waes, C,期刊：Oncogene, 页码：6160-6171 , 文章类型： Article，,卷期：2010年29-46]
- Overexpression of the Yes-associated protein (YAP), and TP53 family members Delta Np63 and p73, have been independently detected in subsets of head and neck squamous cell carcinomas (HNSCCs). YAP may serve as a nuclear c...
- TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells
[作者：Marshall, GM; Bell, JL; Koach, J; Tan, O; Kim, P; Malyukova, A; Thomas, W; Sekyere, EO; Liu, T; Cunningham, AM; Tobias, V; Norris, MD; Haber, M; Kavallaris, M; Cheung, BB,期刊：Oncogene, 页码：6172-6183 , 文章类型： Article，,卷期：2010年29-46]
- The family of tripartite-motif (TRIM) proteins are involved in diverse cellular processes, but are often characterized by critical protein-protein interactions necessary for their function. TRIM16 is induced in different...
- The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program
[作者：Schmidt, S; Schneider, L; Essmann, F; Cirstea, IC; Kuck, F; Kletke, A; Janicke, RU; Wiek, C; Hanenberg, H; Ahmadian, MR; Schulze-Osthoff, K; Nurnberg, B; Piekorz, RP,期刊：Oncogene, 页码：6184-6192 , 文章类型： Article，,卷期：2010年29-46]
- Microtubule-interfering cancer drugs such as paclitaxel (PTX) often cause chemoresistance and severe side effects, including neurotoxicity. To explore potentially novel antineoplastic molecular targets, we investigated t...
- Trisomy 21 leukemias: finding the hits that matter
[作者：Rabson, AB,期刊：Oncogene, 页码：6099-6101 , 文章类型： Editorial Material，,卷期：2010年29-46]
- Down syndrome is associated with a markedly increased risk of childhood leukemias, and identification of chromosome 21 sequences that have a role in leukemogenesis may provide insights into critical pathways and suggest ...
- Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes
[作者：Al-Ejeh, F; Kumar, R; Wiegmans, A; Lakhani, SR; Brown, MP; Khanna, KK,期刊：Oncogene, 页码：6085-6098 , 文章类型： Review，,卷期：2010年29-46]
- The DNA-damage response (DDR) pathways consist of interconnected components that respond to DNA damage to allow repair and promote cell survival. The DNA repair pathways and downstream cellular responses have diverged in...
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