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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共42条记录   MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice [作者：Rivas, MN; Koh, YT; Chen, A; Nguyen, A; Lee, YH; Lawson, G; Chatila, TA,期刊：Journal of clinical investigation, 页码：1933-1947 , 文章类型： Article，,卷期：2012年122-5] Tregs expressing the transcription factor Foxp3 suppress self-reactive T cells, prevent autoimmunity, and help contain immune responses to foreign antigens, thereby limiting the potential for inadvertent tissue damage. M... Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice (vol 121, pg 1871, 2011) [作者：Chan, AC; Drakos, SG; Ruiz, OE; Smith, ACH; Gibson, CC; Ling, J; Passi, SF; Stratman, AN; Sacharidou, A; Revelo, MP; Grossmann, AH; Diakos, NA; Davis, GE; Metzstein, MM; Whitehead, KJ; Li, DY,期刊：Journal of clinical investigation, 页码：1948-1948 , 文章类型： Correction，,卷期：2012年122-5] Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice (vol 122, pg 91, 2012) [作者：Shim, JH; Greenblatt, MB; Singh, A; Brady, N; Hu, D; Drapp, R; Ogawa, W; Kasuga, M; Noda, T; Yang, SH; Lee, SK; Rebel, VI; Glimcher, LH,期刊：Journal of clinical investigation, 页码：1948-1948 , 文章类型： Correction，,卷期：2012年122-5] Constitutively, pathologically, profoundly [作者：Neill, US,期刊：Journal of clinical investigation, 页码：1585-1585 , 文章类型： Editorial Material，,卷期：2012年122-5] There are a hundred reasons to love the JCI and I have loved it truly, madly, and deeply for the last nine years. Alas, I'll have to learn to love the Journal from afar, as tomorrow marks my last official day as Executiv... A conversation with Robert Lefkowitz, Joseph Goldstein, and Michael Brown [作者：Neill, US; Rockman, HA,期刊：Journal of clinical investigation, 页码：1586-1587 , 文章类型： Editorial Material，,卷期：2012年122-5] Lloyd J. Old - a scientific concertmaster Obituary [作者：Pure, E,期刊：Journal of clinical investigation, 页码：1588-1588 , 文章类型： Biographical-Item，,卷期：2012年122-5] Uncovering the role of genomic "dark matter" in human disease [作者：Martin, L; Chang, HY,期刊：Journal of clinical investigation, 页码：1589-1595 , 文章类型： Article，,卷期：2012年122-5] The human genome encodes thousands of long noncociing RNAs (IncRNAs). Although most remain functionally uncharacterized biological "dark matter," IncRNAs have garnered considerable attention for their diverse roles in hu... Degranulation deconstructed [作者：Baehner, RL; Karnovsky, MJ,期刊：Journal of clinical investigation, 页码：1596-1597 , 文章类型： Article，,卷期：2012年122-5] Pediatricians first described the clinical features of chronic granulomatous disease (CGD) in 1959. Almost a decade later, in a collaborative effort that crossed disciplines, we participated in the discoveries that defin... How much vitamin D should I take? [作者：Colon-Emeric, CS; Lyles, KW,期刊：Journal of clinical investigation, 页码：1598-1599 , 文章类型： Editorial Material，,卷期：2012年122-5] Clinical vignette: A 68-year-old woman consults you after a recent bone mineral density screening revealed osteopenia, total hip T score of-1.8. Further evaluation shows her only other abnormal lab value is a serum 25-hy... Gene therapy: too much splice can spoil the dish [作者：Trono, D,期刊：Journal of clinical investigation, 页码：1600-1602 , 文章类型： Editorial Material，,卷期：2012年122-5] The use of integrating vectors for gene therapy - required for stable correction of gene expression - carries the risk of insertional mutagenesis, which can lead to activation of a tumorigenic program. In this issue of t... Epidermal Langerhans cells tune skin reactivity to contact allergens [作者：Udey, MC,期刊：Journal of clinical investigation, 页码：1602-1605 , 文章类型： Editorial Material，,卷期：2012年122-5] Allergic contact dermatitis is a common disorder that has fascinated dermatologists and immunologists for decades. Extensive studies of contact sensitivity reactions in mice established a mechanistic paradigm that has be... Treating myeloma cast nephropathy without treating myeloma [作者：Leung, N,期刊：Journal of clinical investigation, 页码：1605-1608 , 文章类型： Editorial Material，,卷期：2012年122-5] Cast nephropathy is the result of coprecipitation of immunoglobulin free light chains (FLCs) with Tamm-Horsfall glycoprotein (THP). It is a hallmark of multiple myeloma that has significant consequences. Treatment strate... NADPH oxidase regulates efficacy of vaccination in aspergillosis [作者：Deepe, GS,期刊：Journal of clinical investigation, 页码：1608-1611 , 文章类型： Editorial Material，,卷期：2012年122-5] Invasive aspergillosis is often a consequence of immune suppression, and accumulating evidence points to a role for adaptive immunity. Hence, it may be possible to manipulate the adaptive immune system to enhance protect... Liver LXR alpha expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice [作者：Zhang, Y; Breevoort, SR; Angdisen, J; Fu, MG; Schmidt, DR; Holmstrom, SR; Kliewer, SA; Mangelsdorf, DJ; Schulman, IG,期刊：Journal of clinical investigation, 页码：1688-1699 , 文章类型： Article，,卷期：2012年122-5] Liver X receptors (LXR alpha and LXR beta) are important regulators of cholesterol and lipid metabolism, and their activation has been shown to inhibit cardiovascular disease and reduce atherosclerosis in animal models. ... Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells [作者：de Aguero, MG; Vocanson, M; Hacini-Rachinel, F; Taillardet, M; Sparwasser, T; Kissenpfennig, A; Malissen, B; Kaiserlian, D; Dubois, B,期刊：Journal of clinical investigation, 页码：1700-1711 , 文章类型： Article，,卷期：2012年122-5] Allergic contact dermatitis is the most frequent occupational disease in industrialized countries. It is caused by CD8(+) T cell-mediated contact hypersensitivity (CHS) reactions triggered at the site of contact by a var... PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques [作者：Shetty, RD; Velu, V; Titanji, K; Bosinger, SE; Freeman, GJ; Silvestri, G; Amara, RR,期刊：Journal of clinical investigation, 页码：1712-1716 , 文章类型： Article，,卷期：2012年122-5] Hyperimmune activation is a strong predictor of disease progression during pathogenic immunodeficiency virus infections and is mediated in part by sustained type I IFN signaling in response to adventitious microbial infe...