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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共36条记录   Tradition, tradition [作者：Rockman, HA,期刊：Journal of clinical investigation, 页码：785-786 , 文章类型： Editorial Material，,卷期：2012年122-3] Starting with this issue, the Editorial duties for the JCI move to Duke University and the University of North Carolina at Chapel Hill. As we begin our five-year tenure at the helm of this prestigious journal, the tradit... Macrophage plasticity and polarization: in vivo veritas [作者：Sica, A; Mantovani, A,期刊：Journal of clinical investigation, 页码：787-795 , 文章类型： Article，,卷期：2012年122-3] Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage. In response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages undergo M1 (classical) or M2 (alternative) acti... Endothelium: from cellophane to orchestral maestro [作者：Nachman, RL,期刊：Journal of clinical investigation, 页码：796-797 , 文章类型： Editorial Material，,卷期：2012年122-3] Endothelial cells from human umbilical veins were first cultured nearly four decades ago, initiating explosive growth in research in vascular biology and leading to major insights into angiogenesis, vasculogenesis, and t... Unraveling human natural killer cell deficiency [作者：Orange, JS,期刊：Journal of clinical investigation, 页码：798-801 , 文章类型： Editorial Material，,卷期：2012年122-3] NK cells are a component of the innate immune system identified in animals as serving an essential role in antiviral immunity. Establishing their role in human health has been challenging, with the most direct insight co... Unraveling the mystery of the hygiene hypothesis through Helicobacter pylori infection [作者：Matsushima, K; Nagai, S,期刊：Journal of clinical investigation, 页码：801-804 , 文章类型： Editorial Material，,卷期：2012年122-3] Epidemiological studies have revealed an inverse association between Helicobacter pylori infection and the incidence of allergic asthma. This association is consistent with the hygiene hypothesis, which posits that expos... NPs - heart hormones that regulate brown fat? [作者：Whittle, AJ; Vidal-Puig, A,期刊：Journal of clinical investigation, 页码：804-807 , 文章类型： Editorial Material，,卷期：2012年122-3] Thermogenesis in brown adipose tissue (BAT) is well characterized as being under the control of the sympathetic nervous system. The energy-burning capacity of BAT makes it an attractive target for anti-obesity therapies.... DYRK1A in Down syndrome: an oncogene or tumor suppressor? [作者：Birger, Y; Izraeli, S,期刊：Journal of clinical investigation, 页码：807-810 , 文章类型： Editorial Material，,卷期：2012年122-3] Children with Down syndrome (DS) have a markedly increased risk of developing acute megakaryoblastic leukemia (AMKL) and acute lymphoblastic leukemia compared with that of children without DS. Despite recent breakthrough... Popeye proteins: muscle for the aging sinus node [作者：Boukens, BJ; Christoffels, VM,期刊：Journal of clinical investigation, 页码：810-813 , 文章类型： Editorial Material，,卷期：2012年122-3] The electrical impulses that dictate the rhythm of the heartbeat in normal situations and during exercise or stress are initiated by a small number of sinus node pacemaker cells. Senescence and dysfunction of the sinus n... MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans [作者：Hughes, CR; Guasti, L; Meimaridou, E; Chuang, CH; Schimenti, JC; King, PJ; Costigan, C; Clark, AJL; Metherell, LA,期刊：Journal of clinical investigation, 页码：814-820 , 文章类型： Article，,卷期：2012年122-3] An interesting variant of familial glucocorticoid deficiency (FGD), an autosomal recessive form of adrenal failure, exists in a genetically isolated Irish population. In addition to hypocortisolemia, affected children sh... Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency [作者：Gineau, L; Cognet, C; Kara, N; Lach, FP; Dunne, J; Veturi, U; Picard, C; Trouillet, C; Eidenschenk, C; Aoufouchi, S; Alcais, A; Smith, O; Geissmann, F; Feighery, C; Abel, L; Smogorzewska, A; Stillman, B; Vivier, E; Casanova, JL; Jouanguy, E,期刊：Journal of clinical investigation, 页码：821-832 , 文章类型： Article，,卷期：2012年122-3] Natural killer (NK) cells are circulating cytotoxic lymphocytes that exert potent and nonredundant antiviral activity and antitumoral activity in the mouse; however, their function in host defense in humans remains uncle... ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice [作者：Casimiro, MC; Crosariol, M; Loro, E; Ertel, A; Yu, ZR; Dampier, W; Saria, EA; Papanikolaou, A; Stanek, TJ; Li, ZP; Wang, CG; Fortina, P; Addya, S; Tozeren, A; Knudsen, ES; Arnold, A; Pestell, RG,期刊：Journal of clinical investigation, 页码：833-843 , 文章类型： Article，,卷期：2012年122-3] Chromosomal instability (CIN) in tumors is characterized by chromosomal abnormalities and an altered gene expression signature; however, the mechanism of CIN is poorly understood. CCND1 (which encodes cyclin D1) is overe... p27(Kip1) controls cytokinesis via the regulation of citron kinase activation [作者：Serres, MP; Kossatz, U; Chi, Y; Roberts, JM; Malek, NP; Besson, A,期刊：Journal of clinical investigation, 页码：844-858 , 文章类型： Article，,卷期：2012年122-3] p27(Kip1) (p27) acts as a tumor suppressor by inhibiting cyclin-cyclin-dependent kinase (cyclin-CDK) activity. However, mice expressing a form of p27 that is unable to bind or inhibit cyclin-CDK complexes (p27(CK-)) have... DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells [作者：Taira, N; Mimoto, R; Kurata, M; Yamaguchi, T; Kitagawa, M; Miki, Y; Yoshida, K,期刊：Journal of clinical investigation, 页码：859-872 , 文章类型： Article，,卷期：2012年122-3] Dysregulation of the G(1)/S transition in the cell cycle contributes to tumor development. The oncogenic transcription factors c-Jun and c-Myc are indispensable regulators at this transition, and their aberrant expressio... Modulation of noncanonical TGF-beta signaling prevents cleft palate in Tgfbr2 mutant mice [作者：Iwata, J; Hacia, JG; Suzuki, A; Sanchez-Lara, PA; Urata, M; Chai, Y,期刊：Journal of clinical investigation, 页码：873-885 , 文章类型： Article，,卷期：2012年122-3] Patients with mutations in either TGF-beta receptor type I (TGFBR1) or TGF-beta receptor type II (TGFBR2), such as those with Loeys-Dietz syndrome, have craniofacial defects and signs of elevated TGF-beta signaling. Simi... PPAR gamma agonists enhance ET-743-induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcoma [作者：Charytonowicz, E; Terry, M; Coakley, K; Telis, L; Remotti, F; Cordon-Cardo, C; Taub, RN; Matushansky, I,期刊：Journal of clinical investigation, 页码：886-898 , 文章类型： Article，,卷期：2012年122-3] Myxoid round cell liposarcoma (MRCLS) is a common liposarcoma subtype characterized by a translocation that results in the fusion protein TLS:CHOP as well as by mixed adipocytic histopathology. Both the etiology of MRCLS... Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors [作者：Salmon, H; Franciszkiewicz, K; Damotte, D; Dieu-Nosjean, MC; Validire, P; Trautmann, A; Mami-Chouaib, F; Donnadieu, E,期刊：Journal of clinical investigation, 页码：899-910 , 文章类型： Article，,卷期：2012年122-3] Appropriate localization and migration of T cells is a prerequisite for antitumor immune surveillance. Studies using fixed tumor samples from human patients have shown that T cells accumulate more efficiently in the stro...