个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共43条记录   Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice [作者：McNay, DEG; Briancon, N; Kokoeva, MV; Maratos-Flier, E; Flier, JS,期刊：Journal of clinical investigation, 页码：142-152 , 文章类型： Article，,卷期：2012年122-1] In the CNS, the hypothalamic arcuate nucleus (ARN) energy-balance circuit plays a key role in regulating body weight. Recent studies have shown that neurogenesis occurs in the adult hypothalamus, revealing that the ARN e... Obesity is associated with hypothalamic injury in rodents and humans [作者：Thaler, JP; Yi, CX; Schur, EA; Guyenet, SJ; Hwang, BH; Dietrich, MO; Zhao, XL; Sarruf, DA; Izgur, V; Maravilla, KR; Nguyen, HT; Fischer, JD; Matsen, ME; Wisse, BE; Morton, GJ; Horvath, TL; Baskin, DG; Tschop, MH; Schwartz, MW,期刊：Journal of clinical investigation, 页码：153-162 , 文章类型： Article，,卷期：2012年122-1] Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by inflammation both in peripheral tissues and in hypothalamic areas critical for energy homeostasis. Here we report that unlike inflamm... The flip-flop HuR part of the problem or the solution in fighting cancer? [作者：Shultz, JC; Chalfant, CE,期刊：Journal of clinical investigation, 页码：16-19 , 文章类型： Editorial Material，,卷期：2012年122-1] Chronic inflammation has long been appreciated to play a critical role in tumor development and maintenance. Among the mechanisms involved in coordinating the initiation and resolution of inflammation are those responsib... Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis [作者：Hlady, RA; Novakova, S; Opavska, J; Klinkebiel, D; Peters, SL; Bies, J; Hannah, J; Iqbal, J; Anderson, KM; Siebler, HM; Smith, LM; Greiner, TC; Bastola, D; Joshi, S; Lockridge, O; Simpson, MA; Felsher, DW; Wagner, KU; Chan, WC; Christman, JK; Opavsky, R,期刊：Journal of clinical investigation, 页码：163-177 , 文章类型： Article，,卷期：2012年122-1] DNA methyltransferase 3B (Dnmt3b) belongs to a family of enzymes responsible for methylation of cytosine residues in mammals. DNA methylation contributes to the epigenetic control of gene transcription and is deregulated... Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice [作者：Panigrahy, D; Edin, ML; Lee, CR; Huang, S; Bielenberg, DR; Butterfield, CE; Barnes, CM; Mammoto, A; Mammoto, T; Luria, A; Benny, O; Chaponis, DM; Dudley, AC; Greene, ER; Vergilio, JA; Pietramaggiori, G; Scherer-Pietramaggiori, SS; Short, SM; Seth, M; Lih, FB; Tomer, KB; Yang, J; Schwendener, RA; Hammock, BD; Falck, JR; Manthati, VL; Ingber, DE; Kaipainen, A; D'Amore, PA; Kieran, MW; Zeldin, DC,期刊：Journal of clinical investigation, 页码：178-191 , 文章类型： Article，,卷期：2012年122-1] Epoxyeicosatrienoic acids (EETs) are small molecules produced by cytochrome P450 epoxygenases. They are lipid mediators that act as autocrine or paracrine factors to regulate inflammation and vascular tone. As a result, ... Epoxyeicosatrienoic acids: a double-edged sword in cardiovascular diseases and cancer [作者：Wang, DZ; DuBois, RN,期刊：Journal of clinical investigation, 页码：19-22 , 文章类型： Editorial Material，,卷期：2012年122-1] Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases have beneficial effects in certain cardiovascular and kidney diseases. Hence, great efforts have been made to develop... Developmental stage determines estrogen receptor alpha expression and non-genomic mechanisms that control IGF-1 signaling and mammary proliferation in mice [作者：Tian, J; Berton, TR; Shirley, SH; Lambertz, I; Gimenez-Conti, IB; DiGiovanni, J; Korach, KS; Conti, CJ; Fuchs-Young, R,期刊：Journal of clinical investigation, 页码：192-204 , 文章类型： Article，,卷期：2012年122-1] Insulin like growth factor-1 (IGF-1) stimulates increased proliferation and survival of mammary epithelial cells and also promotes mammary tumorigenesis. To study the effects of IGF-1 on the mammary gland in vivo, we use... Editorial position on publishing articles on human organ transplantation [作者：Caplan, AL; Rockman, HA; Turka, LA,期刊：Journal of clinical investigation, 页码：2-2 , 文章类型： Editorial Material，,卷期：2012年122-1] Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes [作者：Rees, MG; Ng, D; Ruppert, S; Turner, C; Beer, NL; Swift, AJ; Morken, MA; Below, JE; Blech, I; Mullikin, JC; McCarthy, MI; Biesecker, LG; Gloyn, AL; Collins, FS,期刊：Journal of clinical investigation, 页码：205-217 , 文章类型： Article，,卷期：2012年122-1] Defining the genetic contribution of rare variants to common diseases is a major basic and clinical science challenge that could offer new insights into disease etiology and provide potential for directed gene- and pathw... Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy [作者：Kashiwakura, JI; Ando, T; Matsumoto, K; Kimura, M; Kitaura, J; Matho, MH; Zajonc, DM; Ozeki, T; Ra, C; MacDonald, SM; Siraganian, RP; Broide, DH; Kawakami, Y; Kawakami, T,期刊：Journal of clinical investigation, 页码：218-228 , 文章类型： Article，,卷期：2012年122-1] IgE-mediated activation of mast cells and basophils underlies allergic diseases such as asthma. Histamine-releasing factor (HRF; also known as translationally controlled tumor protein [TCTP] and fortilin) has been implic... Alteration of hypothalamic cellular dynamics in obesity [作者：Lee, EB; Ahima, RS,期刊：Journal of clinical investigation, 页码：22-25 , 文章类型： Editorial Material，,卷期：2012年122-1] The number of people who suffer from obesity and one or more of its adverse complications is rapidly increasing. It is becoming clear that diet, exercise, and other lifestyle modifications are insufficient strategies to ... Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice [作者：Podowski, M; Calvi, C; Metzger, S; Misono, K; Poonyagariyagorn, H; Lopez-Mercado, A; Ku, T; Lauer, T; McGrath-Morrow, S; Berger, A; Cheadle, C; Tuder, R; Dietz, HC; Mitzner, W; Wise, R; Neptune, E,期刊：Journal of clinical investigation, 页码：229-240 , 文章类型： Article，,卷期：2012年122-1] Chronic obstructive pulmonary disease (COPD) is a prevalent smoking-related disease for which no disease-altering therapies currently exist. As dysregulated TGF-beta signaling associates with lung pathology in patients w... Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR [作者：Schoppy, DW; Ragland, RL; Gilad, O; Shastri, N; Peters, AA; Murga, M; Fernandez-Capetillo, O; Diehl, JA; Brown, EJ,期刊：Journal of clinical investigation, 页码：241-252 , 文章类型： Article，,卷期：2012年122-1] Oncogenic Ras and p53 loss-of-function mutations are common in many advanced sporadic malignancies and together predict a limited responsiveness to conventional chemotherapy. Notably, studies in cultured cells have indic... Rare serotype adenoviral vectors for HIV vaccine development [作者：Michael, NL,期刊：Journal of clinical investigation, 页码：25-27 , 文章类型： Editorial Material，,卷期：2012年122-1] Human adenoviral vectors are being developed for use in candidate vaccines for HIV-1 and other pathogens. However, this approach suffered a setback when an HIV-1 vaccine using an adenovirus type 5 (Ad5) vector failed to ... Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients [作者：Agnihotri, S; Gajadhar, AS; Ternamian, C; Gorlia, T; Diefes, KL; Mischel, PS; Kelly, J; McGown, G; Thorncroft, M; Carlson, BL; Sarkaria, JN; Margison, GP; Aldape, K; Hawkins, C; Hegi, M; Guha, A,期刊：Journal of clinical investigation, 页码：253-266 , 文章类型： Article，,卷期：2012年122-1] Glioblastoma multiforme (GBM) is the most common and lethal of all gliomas. The current standard of care includes surgery followed by concomitant radiation and chemotherapy with the DNA alkylating agent temozolomide (TMZ... Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury [作者：Yoshioka, J; Chutkow, WA; Lee, S; Kim, JB; Yan, J; Tian, R; Lindsey, ML; Feener, EP; Seidman, CE; Seidman, JG; Lee, RT,期刊：Journal of clinical investigation, 页码：267-279 , 文章类型： Article，,卷期：2012年122-1] Classic therapeutics for ischemic heart disease are less effective in individuals with the metabolic syndrome. As the prevalence of the metabolic syndrome is increasing, better understanding of cardiac metabolism is need...