个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共6条记录   The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-MDM2 protein-protein interaction [作者：Clark, RC; Lee, SY; Searcey, M; Boger, DL,期刊：Natural Product Reports , 页码：465-477 , 文章类型： Review，,卷期：2009年26-4] Inhibitors of key protein-protein interactions are emerging as exciting therapeutic targets for the treatment of cancer. One such interaction between MDM2 (HDM2) and p53, that silences the tumour suppression activities o... Rediscovering the bioactivity and ecological role of 1,4-benzoxazinones [作者：Macias, FA; Marin, D; Oliveros-Bastidas, A; Molinillo, JMG,期刊：Natural Product Reports , 页码：478-489 , 文章类型： Review，,卷期：2009年26-4] Compounds of the (2H)-1,4-benzoxazin-3(4H)-one class have attracted the attention of phytochemists since the first isolation of 2,4-dihydroxy- 2H-1,4-benzoxazin-3(4H)-one(DIBOA) and 2,4-dihydroxy-7methoxy-(2H)-1,4-benzox... Biosynthesis of insect spiroacetals [作者：Booth, YK; Kitching, W; De Voss, JJ,期刊：Natural Product Reports , 页码：490-525 , 文章类型： Review，,卷期：2009年26-4] The volatile secretions of numerous species of Coleoptera (beetles), Hymenoptera (wasps, bees) and Diptera (true flies) contain complex blends of spiroacetals. In several species, a certain number of them appear to funct... Conotoxins: natural product drug leads [作者：Halai, R; Craik, DJ,期刊：Natural Product Reports , 页码：526-536 , 文章类型： Review，,卷期：2009年26-4] Venomous marine cone snails harbour a variety of small disulfide-rich peptides called conotoxins, which target a broad range of ion channels, membrane receptors, and transporters. More than 700 species of Conus are thoug... Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds [作者：McIntosh, JA; Donia, MS; Schmidt, EW,期刊：Natural Product Reports , 页码：537-559 , 文章类型： Review，,卷期：2009年26-4] Ribosomally synthesized bacterial natural products rival the nonribosomal peptides in their structural and functional diversity. The last decade has seen substantial progress in the identification and characterization of... Challenges in the synthesis of a unique mono-carboxylic acid antibiotic, (+)-zincophorin [作者：Song, ZL; Lohse, AG; Hsung, RP,期刊：Natural Product Reports , 页码：560-571 , 文章类型： Review，,卷期：2009年26-4] (+)-Zincophorin, also referred to as M144255 or griseocholin, is a polyoxygenated ionophoric antibiotic that was isolated from Streptomyces griseus in 1984. It possesses strong in vivo activity against Gram-positive bact...