- In Vivo Kinetics of Indoxyl Sulfate in Humans and Its Renal Interaction with Angiotensin-Converting Enzyme Inhibitor Quinapril in Rats
[作者:Fujita, T; Ishihara, K; Yasuda, S; Nakamura, T; Maeda, M; Kobayashi, M; Sahashi, K; Ikeda, Y; Kumagai, Y; Majima, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:626-633 , 文章类型: Article,,卷期:2012年341-3]
- Indoxyl sulfate (IS) is an organic anion uremic toxin that accumulates in patients with chronic kidney disease (CKD). The aims of this study were to examine the kinetic profiles of IS in humans at a steady state after mu...
- An Inhibitor of Neuronal Exocytosis (DD04107) Displays Long-Lasting In Vivo Activity against Chronic Inflammatory and Neuropathic Pain
[作者:Ponsati, B; Carreno, C; Curto-Reyes, V; Valenzuela, B; Duart, MJ; Van den Nest, W; Cauli, O; Beltran, B; Fernandez, J; Borsini, F; Caprioli, A; Di Serio, S; Veretchy, M; Baamonde, A; Menendez, L; Barros, F; de la Pena, P; Borges, R; Felipo, V; Planells-Cases, R; Ferrer-Montiel, A,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:634-645 , 文章类型: Article,,卷期:2012年341-3]
- Small peptides patterned after the N terminus of the synaptosomal protein of 25 kDa, a member of the protein complex implicated in Ca2(+)-dependent neuronal exocytosis, inhibit in vitro the release of neuromodulators inv...
- Diltiazem Enhances the Apoptotic Effects of Proteasome Inhibitors to Induce Prostate Cancer Cell Death
[作者:Kaddour-Djebbar, I; Choudhary, V; Lakshmikanthan, V; Shirley, R; El Gaish, M; Al-Shabrawey, M; Al-Husein, B; Zhong, R; Davis, M; Dong, Z; Bollag, WB; Kumar, MV,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:646-655 , 文章类型: Article,,卷期:2012年341-3]
- Diltiazem is a calcium channel blocker used to treat cardiovascular ailments. In addition, reports suggest that diltiazem induces cell death, which could make it a drug of choice for the treatment of cancer associated wi...
- A Model-Based Approach to Predicting the Human Pharmacokinetics of a Monoclonal Antibody Exhibiting Target-Mediated Drug Disposition
[作者:Luu, KT; Bergqvist, S; Chen, EH; Hu-Lowe, D; Kraynov, E,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:702-708 , 文章类型: Article,,卷期:2012年341-3]
- In the drug discovery and development setting, the ability to accurately predict the human pharmacokinetics (PK) of a candidate compound from preclinical data is critical for informing the effective design of the first-i...
- p38 Mitogen-Activated Protein Kinase Is Required for the Antitumor Activity of the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-acetic Acid
[作者:Wu, Q; Quan, HT; Xu, YP; Li, Y; Hu, YH; Lou, LG,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:709-717 , 文章类型: Article,,卷期:2012年341-3]
- 5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a potent vascular disrupting agent, selectively destroys established tumor vasculature, causing a rapid collapse in blood flow that ultimately leads to inhibition of tumor gr...
- Diaminothiazoles Inhibit Angiogenesis Efficiently by Suppressing Akt Phosphorylation
[作者:Thomas, SA; Thamkachy, R; Ashokan, B; Komalam, RJ; Sreerekha, KV; Bharathan, A; Santhoshkumar, TR; Rajasekharan, KN; Sengupta, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:718-724 , 文章类型: Article,,卷期:2012年341-3]
- The prevention of neovessel formation or angiogenesis is a recent popular strategy for limiting and curing cancer. Diaminothiazoles are a class of compounds that have been reported to show promise in the treatment of can...
- Attenuation of Cisplatin-Induced Renal Injury by Inhibition of Soluble Epoxide Hydrolase Involves Nuclear Factor kappa B Signaling
[作者:Liu, YM; Webb, HK; Fukushima, H; Micheli, J; Markova, S; Olson, JL; Kroetz, DL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:725-734 , 文章类型: Article,,卷期:2012年341-3]
- Acute kidney injury is associated with a significant inflammatory response that has been the target of renoprotection strategies. Epoxyeicosatrienoic acids (EETs) are anti-inflammatory cytochrome P450-derived eicosanoids...
- 3,5-Dihydroxybenzoic Acid, a Specific Agonist for Hydroxycarboxylic Acid 1, Inhibits Lipolysis in Adipocytes
[作者:Liu, CL; Kuei, C; Zhu, J; Yu, JX; Zhang, L; Shih, A; Mirzadegan, T; Shelton, J; Sutton, S; Connelly, MA; Lee, G; Carruthers, N; Wu, JJ; Lovenberg, TW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:794-801 , 文章类型: Article,,卷期:2012年341-3]
- Niacin raises high-density lipoprotein and lowers low-density lipoprotein through the activation of the beta-hydroxybutyrate receptor hydroxycarboxylic acid 2 (HCA2) (aka GPR109a) but with an unwanted side effect of cuta...
- Behavioral Effects and Central Nervous System Levels of the Broadly Available kappa-Agonist Hallucinogen Salvinorin A Are Affected by P-Glycoprotein Modulation In Vivo
[作者:Butelman, ER; Caspers, M; Lovell, KM; Kreek, MJ; Prisinzano, TE,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:802-808 , 文章类型: Article,,卷期:2012年341-3]
- Active blood-brain barrier mechanisms, such as the major efflux transporter P-glycoprotein (mdr1), modulate the in vivo/central nervous system (CNS) effects of many pharmacological agents, whether they are used for nonme...
- Is Hydrogen Sulfide-Induced Suspended Animation General Anesthesia?
[作者:Li, RQ; McKinstry, AR; Moore, JT; Caltagarone, BM; Eckenhoff, MF; Eckenhoff, RG; Kelz, MB,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:735-742 , 文章类型: Article,,卷期:2012年341-3]
- Hydrogen sulfide (H(2)S) depresses mitochondrial function and thereby metabolic rates in mice, purportedly resulting in a state of "suspended animation." Volatile anesthetics also depress mitochondrial function, an effec...
- Multidrug and Toxin Extruder Proteins MATE1 and MATE2-K
[作者:Astorga, B; Ekins, S; Morales, M; Wright, SH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:743-755 , 文章类型: Article,,卷期:2012年341-3]
- The present study compared the selectivity of two homologous transport proteins, multidrug and toxin extruders 1 and 2-K (MATE1 and MATE2-K), and developed three-dimensional pharmacophores for inhibitory ligand interacti...
- Effects of Ethanol on GABA(A) Receptors in GABAergic and Glutamatergic Presynaptic Nerve Terminals
[作者:Wakita, M; Shin, MC; Iwata, S; Nonaka, K; Akaike, N,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:809-819 , 文章类型: Article,,卷期:2012年341-3]
- Ethanol (EtOH) has a number of behavioral effects, including intoxication, amnesia, and/or sedation, that are thought to relate to the activation of GABA(A) receptors. However, GABA(A) receptors at different cellular loc...
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