- Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach
[作者:Abadi, AH; Abouel-Ella, DA; Lehmann, J; Tinsley, HN; Gary, BD; Piazza, GA; Abdel-Fattah, MAO,期刊:European Journal of Medicinal Chemistry, 页码:90-97 , 文章类型: Article,,卷期:2010年45-1]
- Two series with the general formula of 4,6-diaryl-2-oxo-1,2 dihydropyridine-3-carbonitriles and their isosteric 4,6-diaryi-2-imino-1,2-dihydropyridine-3-carbonitrile were synthesized through one pot reaction of the appro...
- Synthesis, structure, electrochemistry and spectral characterization of (D-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich Ascites Carcinoma in Swiss albino mice
[作者:Sathisha, MP; Budagumpi, S; Kulkarni, NV; Kurdekar, GS; Revankar, VK; Pai, KSR,期刊:European Journal of Medicinal Chemistry, 页码:106-113 , 文章类型: Article,,卷期:2010年45-1]
- The novel glycosyl saccharide derivative, (D-glucopyranose)-4-phenylthiosemicarbazide (LH) and its complexes, with cobalt(II), nickel(II), copper(II) and zinc(II) were synthesized, characterised and tested for cytotoxic ...
- Discovery of novel antitubercular 2,10-dihydro-4aH-chromeno[3,2-c]pyridin-3-yl derivatives
[作者:Sriram, D; Yogeeswari, P; Dinakaran, M; Banerjee, D; Bhat, P; Gadhwal, S,期刊:European Journal of Medicinal Chemistry, 页码:120-123 , 文章类型: Article,,卷期:2010年45-1]
- Twenty two novel 2,10-dihydro-4aH-chromeno[3,2-c]pyridin-3-yl derivatives were synthesized by reacting 3-formyl chromone, (sub)-2-amino pyridines, N1-(prop-2-ynyl)arylamides in the presence of indium triflate. The compou...
- 1,3-Dipolar cycloaddition of C-aryl-N-phenylnitrones to (R)-1-(1-phenylethyl)-3-[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones: Synthesis and antimycobacterial evaluation of enantiomerically pure spiroisoxazolidines
[作者:Kumar, RS; Perumal, S; Shetty, KA; Yogeeswari, P; Sriram, D,期刊:European Journal of Medicinal Chemistry, 页码:124-133 , 文章类型: Article,,卷期:2010年45-1]
- A series of novel enantiomerically pure spiroisoxazolidines were synthesized regioselectively by the 1,3-dipolar cycloaddition of C-aryl-N-phenylnitrones to (R)-1-(1-phenylethyl)-3-[(E)-arylmethylidenejtetrahydro-4(1H)-p...
- The role of p53 in the cellular toxicity by active trans-platinum complexes containing isopropylamine and hydroxymethylpyridine
[作者:Ramos-Lima, FJ; Moneo, V; Quiroga, AG; Carnero, A; Navarro-Ranninger, C,期刊:European Journal of Medicinal Chemistry, 页码:134-141 , 文章类型: Article,,卷期:2010年45-1]
- Despite some initial research that reported a lack of activity of trans geometry, complexes with general formula trans-[PtCl2(L)(L')] exhibit an important cytotoxic activity in cisplatin-sensitive and resistant cell line...
- Application of Huisgen (3+2) cycloaddition reaction: Synthesis of 1-(2,3-dihydrobenzofuran-2-yl-methyl [1,2,3]-triazoles and their antitubercular evaluations
[作者:Tripathi, RP; Yadav, AK; Ajay, A; Bisht, SS; Chaturvedi, V; Sinha, SK,期刊:European Journal of Medicinal Chemistry, 页码:142-148 , 文章类型: Article,,卷期:2010年45-1]
- 1,4-Disubstituted-1,2,3-triazoles (3-27) have been synthesized by [3+2] cycloaddition of different 2-(azidomethyl)-dihydronaptho(benzo)furans (2a, 2b, 2c and 2d) with different alkynes. All the compounds were screened fo...
- Design and synthesis of novel P2 substituents in diol-based HIV protease inhibitors
[作者:Meredith, JA; Wallberg, H; Vrang, L; Oscarson, S; Parkes, K; Hallberg, A; Samuelsson, B,期刊:European Journal of Medicinal Chemistry, 页码:160-170 , 文章类型: Article,,卷期:2010年45-1]
- The synthesis and SAR of HIV-1 protease inhibitors containing novel P2 structural elements are presented. The inhibitors were designed having hydrogen bond accepting P2 substituents to probe potential favorable interacti...
- Synthesis of some new pyrazolo[3,4-d]pyrimidine derivatives of expected anticancer and radioprotective activity
[作者:Ghorab, MM; Ragab, FA; Alqasoumi, SI; Alafeefy, AM; Aboulmagd, SA,期刊:European Journal of Medicinal Chemistry, 页码:171-178 , 文章类型: Article,,卷期:2010年45-1]
- On the account of the reported anticancer activity of pyrazolo[3,4-d]pyrimidines, a new series of pyrazolo[3,4-d]pyrimidine derivatives were synthesized and tested for in-vitro anticancer activity against Ehrlich Ascites...
- Alkyl and dialkylaminoethyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes and their antiplasmodial and antitrypanosomal activities
[作者:Faist, J; Seebacher, W; Kaiser, M; Brun, R; Saf, R; Weis, R,期刊:European Journal of Medicinal Chemistry, 页码:179-185 , 文章类型: Article,,卷期:2010年45-1]
- N-Alkyl and N-(2-dialkylaminoethyl) derivatives of 5-amino-2-azabicyclo-nonanes were prepared and tested in vitro for their activities against the multidrug-resistant K-1 strain of Plasmodium falciparum and Trypanosoma b...
- Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase
[作者:Katalinic, M; Rusak, G; Barovic, JD; Sinko, G; Jelic, D; Antolovic, R; Kovarik, Z,期刊:European Journal of Medicinal Chemistry, 页码:186-192 , 文章类型: Article,,卷期:2010年45-1]
- Selected flavonoids: galangin, kaempferol, quercetin, myricetin, fisetin, apigenin, luteolin and rutin, reversibly inhibited human butyrylcholinesterase (BChE, EC 3.1.1.8). Inhibition potency of the flavonoids we attribu...
- Identification of (beta-carboxyethyl)-rhodanine derivatives exhibiting peroxisome proliferator-activated receptor gamma activity
[作者:Choi, J; Ko, Y; Lee, HS; Park, YS; Yang, Y; Yoon, S,期刊:European Journal of Medicinal Chemistry, 页码:193-202 , 文章类型: Article,,卷期:2010年45-1]
- We applied an improved virtual screening scheme combining ligand-centric and receptor-centric methods for the identification of a new series of PPAR gamma agonists known as (beta-carboxyethyl)-rhodanine derivatives which...
- Synthesis, spectral characterization and biological evaluation of phosphorylated derivatives of galanthamine
[作者:Rao, VK; Rao, AJ; Reddy, SS; Raju, CN; Rao, PV; Ghosh, SK,期刊:European Journal of Medicinal Chemistry, 页码:203-209 , 文章类型: Article,,卷期:2010年45-1]
- A series of novel phosphorylated derivatives of galanthamine 6-11 and 12-17 were synthesized in two step process with high yields. In the first step galanthamine 1 was reacted with bis (2-chloroethyl) phosphoramidic dich...
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