- Synthesis, characterization and in vitro evaluation of new oxorhenium- and oxotechnetium-CCK4 derivatives as molecular imaging agents for CCK2-receptor targeting
[作者:Dorbes, S; Mestre-Voegtle, B; Coulais, Y; Picard, C; Silvente-Poirot, S; Poirot, M; Benoist, E,期刊:European Journal of Medicinal Chemistry, 页码:423-429 , 文章类型: Article,,卷期:2010年45-2]
- The goal of this study is to design new Tc-99m-radiolabelled shortened CCK derivatives that might be suitable for the molecular imaging of cholecystokinin-2 receptors (CCK2-R), these receptors being over-expressed in a n...
- Synthesis and antimalarial evaluation of 1, 3, 5-trisubstituted pyrazolines
[作者:Acharya, BN; Saraswat, D; Tiwari, M; Shrivastava, AK; Ghorpade, R; Bapna, S; Kaushik, MP,期刊:European Journal of Medicinal Chemistry, 页码:430-438 , 文章类型: Article,,卷期:2010年45-2]
- A series of 1,3,5-trisubstituted pyrazolines were synthesized and evaluated for in vitro antimalarial efficacy against chloroquine sensitive (MRC-02) as well as chloroquine resistant (RKL9) strains of Plasmodium falcipar...
- Synthesis, antitumor activity and molecular docking study of novel Sulfonamide-Schiff's bases, thiazolidinones, benzothiazinones and their C-nucleoside derivatives
[作者:Kamel, MM; Ali, HI; Anwar, MM; Mohamed, NA; Soliman, AM,期刊:European Journal of Medicinal Chemistry, 页码:572-580 , 文章类型: Article,,卷期:2010年45-2]
- A series of sulfapyridine-polyhydroxyalkylidene (or arylidene)-imino derivatives (Schiff's bases) 2a-c and 4a-e were prepared by condensation of 4-amino-N-pyridin-2-ylbenzenesulfonamide (1) with different monosaccharides...
- Synthesis and cytotoxic activity of psorospermin and acronycine analogues in the 3-propyloxy-acridin-9(10H)-one and -benzo[b]acridin-12(5H)-one series
[作者:Boutefnouchet, S; Minh, NT; Putrus, R; Pfeiffer, B; Leonce, S; Pierre, A; Michel, S; Tillequin, F; Lallemand, MC,期刊:European Journal of Medicinal Chemistry, 页码:581-587 , 文章类型: Article,,卷期:2010年45-2]
- In order to explore the structure-activity relationships in the acronycine and psorospermin series, simplified analogues of the highly cytotoxic (+/-)-(2R*,1'R*)-5-methoxy-11-methyl-2-(2-methyloxiran-2-yl)-1,2-dihydro-11...
- Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins
[作者:Alvarez, C; Alvarez, R; Corchete, P; Perez-Melero, C; Pelaez, R; Medarde, M,期刊:European Journal of Medicinal Chemistry, 页码:588-597 , 文章类型: Article,,卷期:2010年45-2]
- A new family of phenstatin analogues has been synthesized and assayed. This family simultaneously incorporates modifications of the A-ring (replacement of the 3,4,5-trimethoxyphenyl by the 2,3,4-trimethoxyphenyl arrangem...
- Antibacterial and DNA interaction studies of zinc(II) complexes with quinolone family member, ciprofloxacin
[作者:Patel, M; Chhasatia, M; Parmar, P,期刊:European Journal of Medicinal Chemistry, 页码:439-446 , 文章类型: Article,,卷期:2010年45-2]
- DNA binding and cleavage characteristics of Zn(II) complexes have been investigated. The DNA interaction property of the complexes has been investigated using absorption spectra, viscosity measurements, as well as gel el...
- Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D-2 synthase
[作者:Weber, JE; Oakley, AJ; Christ, AN; Clark, AG; Hayes, JD; Hall, R; Hume, DA; Board, PG; Smythe, ML; Flanagan, JU,期刊:European Journal of Medicinal Chemistry, 页码:447-454 , 文章类型: Article,,卷期:2010年45-2]
- Prostaglandin D-2 synthesised by the hematopoietic prostaglandin D-2 synthase has a pro-inflammatory effect in allergic asthma, regulating many hallmark characteristics of the disease. Here we describe identification of ...
- Synthesis and spectroscopy of Co-II, Ni-II, Cu-II and Zn-II complexes derived from 3,5-disubstituted-1H-pyrazole derivative: A special emphasis on DNA binding and cleavage studies
[作者:Budagumpi, S; Kulkarni, NV; Kurdekar, GS; Sathisha, MP; Revankar, VK,期刊:European Journal of Medicinal Chemistry, 页码:455-462 , 文章类型: Article,,卷期:2010年45-2]
- A series of novel Co-II, Ni-II, Cu-II and Zn-II complexes of 1H-pyrazole-3,5-dicarboxylic(2'-hydroxy-3'-hydrazinequinoxaline) has been prepared and characterized by the spectral and analytical techniques. Cull ion reacts...
- Ruthenium (II) phosphine/picolinate complexes as antimycobacterial agents
[作者:Pavan, FR; Von Poelhsitz, G; do Nascimento, FB; Leite, SRA; Batista, AA; Deflon, VM; Sato, DN; Franzblau, SG; Leite, CQF,期刊:European Journal of Medicinal Chemistry, 页码:598-601 , 文章类型: Article,,卷期:2010年45-2]
- The synthesis, characterization and the anti-Mycobacterium tuberculosis (MTB) activities of three ruthenium complexes containing the 2-pyridinecarboxylic acid anion (picolinate), with formulae cis-[Ru(pic)(dppm)(2)]PF6 (...
- Identification of benzofuro[2,3-b]quinoline derivatives as a new class of antituberculosis agents
[作者:Yang, CL; Tseng, CH; Chen, YL; Lu, CM; Kao, CL; Wu, MH; Tzeng, CC,期刊:European Journal of Medicinal Chemistry, 页码:602-607 , 文章类型: Article,,卷期:2010年45-2]
- A series of 11-alkoxylated and 11-aminated benzofuro[2,3-b]quinoline derivatives were designed, synthesized, and evaluated for their anti-TB and cytotoxic activities. The known 11-chlorobenzofuro[2,3-b]quinoline (3) was ...
- Modulation of carcinogen metabolizing enzymes by new fused heterocycles pendant to 5,6,7,8-tetrahydronaphthalene derivatives
[作者:Hamdy, NA; Gamal-Eldeen, AM; Abdel-Aziz, HA; Fakhr, IMI,期刊:European Journal of Medicinal Chemistry, 页码:463-470 , 文章类型: Article,,卷期:2010年45-2]
- The treatment of 2-bromo-1-(5,6,7,8-tetrahydro-naphthalen-2-yl)-ethanone (1) with pyridine, 2-methylpyridine or 4-methylpyridine afforded their corresponding pyridinum bromides 3a-c. The latter salts reacted with activat...
- New palladium(II) complexes bearing pyrazole-based Schiff base ligands: Synthesis, characterization and cytotoxicity
[作者:Abu-Surrah, AS; Abu Safieh, KA; Ahmad, IM; Abdalla, MY; Ayoub, MT; Qaroush, AK; Abu-Mahtheieh, AM,期刊:European Journal of Medicinal Chemistry, 页码:471-475 , 文章类型: Article,,卷期:2010年45-2]
- Reactions of 5-hydrazino-1,3-dimethyl-4-nitro-1H-pyrazole (1) with substituted benzaldehydes (2-5) in methanol gave the new substituted benzaldehyde (1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)hydrazone Schiff base ligands (6-...
- Original quinazoline derivatives displaying antiplasmodial properties
[作者:Kabri, Y; Azas, N; Dumetre, A; Hutter, S; Laget, M; Verhaeghe, P; Gellis, A; Vanelle, P,期刊:European Journal of Medicinal Chemistry, 页码:616-622 , 文章类型: Article,,卷期:2010年45-2]
- The multistep synthesis of new quinazoline-derived molecules and their in vitro antiplasmodial evaluation on the W2 chloroquino-resistant Plasmodium falciparum strain is described herein. These molecules have also been s...
- Structure-activity relationships and mechanism of action of antitumor bis 8-hydroxyquinoline substituted benzylamines
[作者:Madonna, S; Beclin, C; Laras, Y; Moret, V; Marcowycz, A; Lamoral-Theys, D; Dubois, J; Barthelemy-Requin, M; Lenglet, G; Depauw, S; Cresteil, T; Aubert, G; Monnier, V; Kiss, R; David-Cordonnier, MH; Kraus, JL,期刊:European Journal of Medicinal Chemistry, 页码:623-638 , 文章类型: Article,,卷期:2010年45-2]
- A series of twenty six 8-hydroxyquinoline substituted amines, structurally related to compounds 2 and 3, were synthesized to evaluate the effects of structural changes on antitumor activity and understand their mechanism...
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