- Synthesis and characterization of novel fatty acid analogs of cholesterol: In vitro antimicrobial activity
[作者:Banday, MR; Farshori, NN; Ahmad, A; Khan, AU; Rauf, A,期刊:European Journal of Medicinal Chemistry, 页码:1459-1464 , 文章类型: Article,,卷期:2010年45-4]
- In the present study we synthesized, characterized and checked the antimicrobial activity of fatty acid analogs of cholesterol. The synthesized compounds were characterized using IR, H-1 NMR, C-13 NMR and mass spectral d...
- Synthesis and anti-tuberculosis activity of new hetero(Mn, Co, Ni)trinuclear iron(III) furoates
[作者:Melnic, S; Prodius, D; Stoeckli-Evans, H; Shova, S; Turta, C,期刊:European Journal of Medicinal Chemistry, 页码:1465-1469 , 文章类型: Article,,卷期:2010年45-4]
- New hetero(mu(3)-oxo)trinuclear iron(III) furoates with the general formulas [Fe2MO(alpha-Fur)(6)(L)(H2O)(2)]. where L = THF (1-3), DMF (4-5), M = Mn2+ (1, 4), Co2+ (2, 5), Ni2+ (3, 6) and [Fe2MO(alpha-Fur)(6)(3Cl-Py)(3)...
- Synthesis, biological and medicinal significance of S-glycosido-thieno[2,3-d]-pyrimidines as new anti-inflammatory and analgesic agents
[作者:Hafez, HN; El-Gazzar, ARBA; Nawwar, GAM,期刊:European Journal of Medicinal Chemistry, 页码:1485-1493 , 文章类型: Article,,卷期:2010年45-4]
- Several 2-thioglycosides were prepared. Glycosylation of 2-thioxo-thieno[2,3-d]-pyrimidines 5a,b with 1-bromo-2,3,5-tri-O-acetyl-alpha-D-arabinofuranosyle 7, 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl and galacto-pyra...
- Anti-HSV-1 activity and mechanism of action of some new synthesized substituted pyrimidine, thiopyrimidine and thiazolopyrimidine derivatives
[作者:Mohamed, SF; Flefel, EM; Amr, AEE; El-Shafy, DNA,期刊:European Journal of Medicinal Chemistry, 页码:1494-1501 , 文章类型: Article,,卷期:2010年45-4]
- A series of heterocyclic derivatives 2-16 conjugated with tetrahydronaphthalene moiety were synthesized as antiviral agents by using 1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanone as starting material. The antiviral scree...
- An eco-friendly synthesis and antimicrobial activities of dihydro-2H-benzo- and naphtho-1,3-oxazine derivatives
[作者:Mathew, BP; Kumar, A; Sharma, S; Shukla, PK; Nath, M,期刊:European Journal of Medicinal Chemistry, 页码:1502-1507 , 文章类型: Article,,卷期:2010年45-4]
- A series of 3,4-dihydro-2H-benzo[e]-, 2,3-dihydro-1H-naphtho[1,2-e]-, 3,4-dihydro-2H-naphtho[2,1-e][1,3]oxazine and 1,2-bis(3,4-dihydrobenzo[e][1,3]oxazin-3(4H)-yl)ethane derivatives was obtained through an eco-friendly ...
- Pharmacophore-based 3D QSAR studies on a series of high affinity 5-HT1A receptor ligands
[作者:Weber, KC; Salum, LB; Honorio, KM; Andricopulo, AD; da Silva, ABF,期刊:European Journal of Medicinal Chemistry, 页码:1508-1514 , 文章类型: Article,,卷期:2010年45-4]
- 5-HT1A receptor antagonists have been employed to treat depression, but the lack of structural information on this receptor hampers the design of specific and selective ligands. In this study, we have performed CoMFA stu...
- Synthesis and cytotoxic evaluation of N-2-benzylated quaternary beta-carboline amino acid ester conjugates
[作者:Ma, CM; Cao, RH; Shi, BX; Li, SX; Chen, ZY; Yi, W; Peng, WL; Ren, ZH; Song, HC,期刊:European Journal of Medicinal Chemistry, 页码:1515-1523 , 文章类型: Article,,卷期:2010年45-4]
- The beta-carboline alkaloids have been characterized as a class of potential antitumor agents. To further enhance the cytotoxic potency and improve water solubility of beta-carboline, a series of new beta-carboline amino...
- Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma
[作者:Graebin, CS; Madeira, MD; Yokoyama-Yasunaka, JKU; Miguel, DC; Uliana, SRB; Benitez, D; Cerecetto, H; Gonzalez, M; da Rosa, RG; Eifler-Lima, VL,期刊:European Journal of Medicinal Chemistry, 页码:1524-1528 , 文章类型: Article,,卷期:2010年45-4]
- The synthesis and in vitro activity of R(+)-Limonene derivatives against Leishmania and Trypanosoma cruzi strains are reported. Seven compounds have shown better in vitro activity against Leishmania (V.)braziliensis than...
- Synthesis and evaluation of some new substituted benzothiazepine and benzoxazepine derivatives as anticonvulsant agents
[作者:Garg, N; Chandra, T; Archana; Jain, AB; Kumar, A,期刊:European Journal of Medicinal Chemistry, 页码:1529-1535 , 文章类型: Article,,卷期:2010年45-4]
- A new series of 4-(4'-Hydroxyphenyl)-2-(3-substitutedphenyl)-3-(4-substitutedphenylamino methylene)-2,3-dihydro-1,5-benzothiazepines (3a-3j) and 4-(4'-Hydroxyphenyl)-2-(3-substituted phenyl)-3(4-substitutedphenylaminomet...
- Triazole incorporated thiazoles as a new class of anticonvulsants: Design, synthesis and in vivo screening
[作者:Siddiqui, N; Ahsan, W,期刊:European Journal of Medicinal Chemistry, 页码:1536-1543 , 文章类型: Article,,卷期:2010年45-4]
- Various 3-[4-(substituted phenyl)-1,3-thiazol-2-ylamino1-4-(substituted phenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thiones (7a-t) were designed keeping in view the structural requirements suggested in the pharmacophore mode...
- A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies
[作者:Tsai, KC; Chen, YC; Hsiao, NW; Wang, CL; Lin, CL; Lee, YC; Li, MY; Wang, BH,期刊:European Journal of Medicinal Chemistry, 页码:1544-1551 , 文章类型: Article,,卷期:2010年45-4]
- Computational chemistry is playing an increasingly important role in drug design and discovery, structural biology, and quantitative structure-activity relationship (QSAR) studies. For QSAR work, selecting an appropriate...
- Synthesis and study of some new 1,3-isoindoledione derivatives as potential antibacterial agents
[作者:Khalil, AM; Berghot, MA; Gouda, MA,期刊:European Journal of Medicinal Chemistry, 页码:1552-1559 , 文章类型: Article,,卷期:2010年45-4]
- In an effort to establish new candidates with improved antibacterial activities, we reported here the synthesis and in vitro antibacterial evaluation of various series of 2-substituted-3a,4,9,9a-tetrahydro-4,9-benzeno-be...
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