- Synthesis and biological evaluation of novel spiro 6-methoxytetralin-1,3 '-pyrrolidine based organoselenocyanates against cadmium-induced oxidative and hepatic damage in mice
[作者:Hossain, U; Sharma, AK; Ghosh, S; Bhattacharya, S,期刊:European Journal of Medicinal Chemistry, 页码:3265-3273 , 文章类型: Article,,卷期:2010年45-8]
- A series of novel organoselenocyanate compounds (6a-d) having spiro[tetralin-1,3'-pyrrolidine] moiety were synthesized. The compounds were evaluated for their inhibitory activity against cadmium- (Cd) induced toxicity in...
- Synthesis of 2-(pyrimidin-2-yl)-1-phenyl-2,3,4,9-tetrahydro-1H-beta-carbolines as antileishmanial agents
[作者:Kumar, R; Khan, S; Verma, A; Srivastava, S; Viswakarma, P; Gupta, S; Meena, S; Singh, N; Sarkar, J; Chauhan, PMS,期刊:European Journal of Medicinal Chemistry, 页码:3274-3280 , 文章类型: Article,,卷期:2010年45-8]
- A series of 2-(pyrimidin-2-yl)-1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline derivatives has been synthesized and evaluated for antileishmanial activity against Leishmania donovani. Compound 8 exhibited best antileishman...
- Novel 6,8-dibromo-4(3H)quinazolinone derivatives of anti-bacterial and anti-fungal activities
[作者:Mohamed, MS; Kamel, MM; Kassem, EMM; Abotaleb, N; Abd El-moez, SI; Ahmed, MF,期刊:European Journal of Medicinal Chemistry, 页码:3311-3319 , 文章类型: Article,,卷期:2010年45-8]
- Starting from 4-(6,8-dibromo-2-phenyl-4-oxo-(4H)-quinazolin-3-yl)-benzoic acid ethyl ester (II) and its acid hydrazide III, a new series of Schiff bases IV and their cyclized products, thiazolidinones V, oxadiazole VIII,...
- Synthesis of 2-substituted-N-[4-(1-methyl-4,5-diphenyl-1H-imidazole-2-yl) phenyl]acetamide derivatives and evaluation of their anticancer activity
[作者:Ozkay, Y; Isikdag, I; Incesu, Z; Akalin, G,期刊:European Journal of Medicinal Chemistry, 页码:3320-3328 , 文章类型: Article,,卷期:2010年45-8]
- In the present study 18 novel imidazole-(benz)azole and imidazole-piperazine derivatives were synthesized in order to investigate their probable anticancer activity. The structures of the compounds were confirmed by IR, ...
- Synthesis, characterization and antimicrobial studies of 2-(4-methoxy-phenyl)-5-methyl-4-(2-arylsulfanyl-ethyl)-2,4-dihydro-[1,2,4] triazolo-3-ones and their corresponding sulfones
[作者:Patil, BS; Krishnamurthy, G; Naik, HSB; Latthe, PR; Ghate, M,期刊:European Journal of Medicinal Chemistry, 页码:3329-3334 , 文章类型: Article,,卷期:2010年45-8]
- In the present investigation, a series of novel 2-(4-methoxy-phenyl)-5-methyl-4-(2-arylsulfanyl-ethyl)-2,4-dihydro-[1,2,4] triazolo-3-ones and their corresponding sulfones were prepared with the objective of developing b...
- Discovery of new 1,3,5-triazine scaffolds with potent activity against Mycobacterium tuberculosis H37Rv
[作者:Sunduru, N; Gupta, L; Chaturvedi, V; Dwivedi, R; Sinha, S; Chauhan, PMS,期刊:European Journal of Medicinal Chemistry, 页码:3335-3345 , 文章类型: Article,,卷期:2010年45-8]
- A series of eighty one 2,4,6-trisubstituted-1,3,5-triazines were synthesized and evaluated in vitro for the growth inhibition of Mycobacterium tuberculosis H37Rv. Fifteen compounds from this series exhibited good to mode...
- Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - Part-1
[作者:Aly, MM; Mohamed, YA; El-Bayouki, KAM; Basyouni, WM; Abbas, SY,期刊:European Journal of Medicinal Chemistry, 页码:3365-3373 , 文章类型: Article,,卷期:2010年45-8]
- Novel 3-aryl-4(3H)-quinazolinone-2-carboxaldehydes, their corresponding Schiffs base and thiosemicarbazone derivatives were synthesized from the starting 5-iodo anthranilic acid. Copper(II), zinc(II) complexes of some th...
- New quinoline derivatives: Synthesis and investigation of antibacterial and antituberculosis properties
[作者:Eswaran, S; Adhikari, AV; Chowdhury, IH; Pal, NK; Thomas, KD,期刊:European Journal of Medicinal Chemistry, 页码:3374-3383 , 文章类型: Article,,卷期:2010年45-8]
- Four new series of quinoline derivatives were synthesized starting from 2-trifluoromethyl aniline through multi-step reactions. In the reaction sequence, substituted aniline was cyclized to 4-hydroxy quinoline 1, which w...
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