- Photodynamic effects of isosteric water-soluble phthalocyanines on human nasopharynx KB carcinoma cells
[作者:Marino, J; Vior, MCG; Dicelio, LE; Roguin, LP; Awruch, J,期刊:European Journal of Medicinal Chemistry, 页码:4129-4139 , 文章类型: Article,,卷期:2010年45-9]
- The photodynamic activity of water-soluble cationic zinc(II) phthalocyanines using human nasopharynx carcinoma (KB cells) was investigated. A sulfur-linked cationic dye, named: 2,9(10),16(17),23(24)-tetrakis [(2-trimethy...
- Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs
[作者:Sharma, AK; Sk, UH; Gimbor, MA; Hengst, JA; Wang, XJ; Yun, J; Amin, S,期刊:European Journal of Medicinal Chemistry, 页码:4149-4156 , 文章类型: Article,,卷期:2010年45-9]
- Sphingosine kinase (SphK) is a lipid kinase with oncogenic activity, and SphK inhibitors (SKIS) are known for their anti-cancer activity. Here, we report highly efficient syntheses of SKIs and their aspirinyl (Asp) analo...
- Structure-activity relationships of indole compounds derived from combretastatin A4: Synthesis and biological screening of 5-phenylpyrrolo[3,4-a]carbazole-1,3-diones as potential antivascular agents
[作者:Ty, N; Dupeyre, G; Chabot, GG; Seguin, J; Quentin, L; Chiaroni, A; Tillequin, F; Scherman, D; Michel, S; Cachet, X,期刊:European Journal of Medicinal Chemistry, 页码:3726-3739 , 文章类型: Article,,卷期:2010年45-9]
- A series of 5-(3',4',5'-trimethoxyphenyl)pyrrolo[3,4-a]carbazole-1,3(2H,10H)-diones was designed as cis-restricted analogues of 3-aroylindoles, arylthioindoles and 3-benzylidoneindolin-2-ones derived from combretastatin ...
- 1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: Structure-affinity/activity relationship at alpha(1)-adrenoceptor subtypes and at 5-HT1A receptors
[作者:Franchini, S; Prandi, A; Baraldi, A; Sorbi, C; Tait, A; Buccioni, M; Marucci, G; Cilia, A; Pirona, L; Fossa, P; Cichero, E; Brasili, L,期刊:European Journal of Medicinal Chemistry, 页码:3740-3751 , 文章类型: Article,,卷期:2010年45-9]
- A series of 1,3-dioxolane-based compounds incorporating a lactam (2-4) or imide (5-7) moiety was synthesized and the pharmacological profile at alpha(1)-adrenoceptor subtypes and 5-HT1A receptor was assessed through bind...
- Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors
[作者:Chenna, BC; King, JR; Shinkre, BA; Glover, AL; Lucius, AL; Velu, SE,期刊:European Journal of Medicinal Chemistry, 页码:3752-3761 , 文章类型: Article,,卷期:2010年45-9]
- Synthetic methods have been developed for lead Sortase A inhibitors identified from previous studies. Several derivatives of the lead inhibitor were synthesized to derive preliminary structure activity relationships (SAR...
- Synthesis and reactivity studies on new copper(II) complexes: DNA binding, generation of phenoxyl radical, SOD and nuclease activities
[作者:Ghosh, K; Kumar, P; Tyagi, N; Singh, UP; Aggarwal, V; Baratto, MC,期刊:European Journal of Medicinal Chemistry, 页码:3770-3779 , 文章类型: Article,,卷期:2010年45-9]
- Tridentate ligand PhimpH binds to Cu(II) centre after deprotonation affording a new family of complexes [Cu(Phimp)(H2O)](2)(ClO4)(2) (1). [Cu(Phimp)(2)] (2) and Ku(phimp)(L)] (3-5) where L are CH3COO-, SCN- and NO respec...
- Novel N-phenyl dichloroacetamide derivatives as anticancer reagents: Design, synthesis and biological evaluation
[作者:Yang, YC; Shang, PH; Cheng, CM; Wang, DC; Yang, P; Zhang, F; Li, TW; Lu, AJ; Zhao, YF,期刊:European Journal of Medicinal Chemistry, 页码:4300-4306 , 文章类型: Article,,卷期:2010年45-9]
- A current study shows that sodium dichloroacetate (DCA) can induce cancer cell apoptosis and inhibit tumor growth, but its cytotoxic activity is low (IC50 > 1000 mu M for A549). In this paper, a variety of DCA derivative...
- Design and synthesis of novel isoxazole-based HDAC inhibitors
[作者:Conti, P; Tamborini, L; Pinto, A; Sola, L; Ettari, R; Mercurio, C; De Micheli, C,期刊:European Journal of Medicinal Chemistry, 页码:4331-4338 , 文章类型: Article,,卷期:2010年45-9]
- A series of isoxazole-based histone deacetylase (HDAC) inhibitors structurally related to SAHA were designed and synthesized. The isoxazole moiety was inserted in the vicinity of the Zn2+-binding group in order to check ...
- New substituted 4-arylaminoquinazolines as potent inhibitors of breast tumor cell lines: In vitro and docking experiments
[作者:de Oliveira, AN; Bocca, CC; Carvalho, JE; Ruiz, ALG; Silva, TP; Rittner, R; Hoehr, NF,期刊:European Journal of Medicinal Chemistry, 页码:4339-4342 , 文章类型: Article,,卷期:2010年45-9]
- The arylquinazolines represent significant advances in the clinical management of breast cancer. Nevertheless some confirmatory studies must be considered to foster the use of anti-EGFR therapies including safety and cli...
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