- Reduction of Akt2 inhibits migration and invasion of glioma cells
[作者:Zhang, BB; Gu, F; She, CH; Guo, H; Li, WL; Niu, RF; Fu, L; Zhang, N; Ma, YJ,期刊:International Journal of Cancer, 页码:585-595 , 文章类型: Article,,卷期:2009年125-3]
- Malignant gliomas have a tendency to invade diffusely into surrounding healthy brain tissues, thereby precluding their successful surgical removal. The serine/threonine kinase Akt2 is well known as an important regulator...
- Common variants in the UBC9 gene encoding the SUMO-conjugating enzyme are associated with breast tumor grade
[作者:Dunnebier, T; Bermejo, JL; Haas, S; Fischer, HP; Pierl, CB; Justenhoven, C; Brauch, H; Baisch, C; Gilbert, M; Harth, V; Spickenheuer, A; Rabstein, S; Pesch, B; Bruning, T; Ko, YD; Hamann, U,期刊:International Journal of Cancer, 页码:596-602 , 文章类型: Article,,卷期:2009年125-3]
- UBC9 encodes a protein that conjugates small ubiquitin-related modifier (SUMO) to target proteins resulting in a change of their localization, activity or stability. Genetic variability may affect expression and activity...
- Copy number gain and oncogenic activity of YWHAZ/14-3-3 zeta in head and neck squamous cell carcinoma
[作者:Lin, MT; Morrison, CD; Jones, S; Mohamed, N; Bucher, J; Plass, C,期刊:International Journal of Cancer, 页码:603-611 , 文章类型: Article,,卷期:2009年125-3]
- Gene amplification, a common mechanism for oncogene activation in cancers, has been used in the discovery of novel oncogenes. Low-level copy number gains are frequently observed in head and neck squamous cell carcinomas ...
- Gene expression profiling of alpha-radiation-induced rat osteosarcomas: Identification of dysregulated genes involved in radiation-induced tumorigenesis of bone
[作者:Daino, K; Ugolin, N; Altmeyer-Morel, S; Guilly, MN; Chevillard, S,期刊:International Journal of Cancer, 页码:612-620 , 文章类型: Article,,卷期:2009年125-3]
- To better understand the molecular basis of radiation-induced osteosarcoma (OS), we performed global gene expression profiling of rat OS tumors induced by the bone-seeking alpha emitter Pu-238, and the expression profile...
- A study on sequence variations in pre-S/surface, X and enhancer II/core promoter/precore regions of occult hepatitis B virus in non-B, non-C hepatocellular carcinoma patients in Taiwan
[作者:Chen, CH; Changchien, CS; Lee, CM; Tung, WC; Hung, CH; Hu, TH; Wang, JH; Wang, JC; Lu, SN,期刊:International Journal of Cancer, 页码:621-629 , 文章类型: Article,,卷期:2009年125-3]
- This study was to investigate the clinical significance and virologic factors of occult hepatitis B virus (HBV) infection in hepatocellular carcinoma (HCC) patients without hepatitis B surface antigen (HBsAg) or anti-hep...
- OX40 costimulation can abrogate Foxp3(+) regulatory T cell-mediated suppression of antitumor immunity
[作者:Kitamura, N; Murata, S; Ueki, T; Mekata, E; Reilly, RT; Jaffee, EM; Tani, T,期刊:International Journal of Cancer, 页码:630-638 , 文章类型: Article,,卷期:2009年125-3]
- Regulatory T cells (Tregs) play an important role in maintaining immunological tolerance that is one of the main obstacles to overcome for improving antitumor immunity. Recently, the Treg has been shown to constitutively...
- An integrated humoral and cellular response is elicited in pancreatic cancer by alpha-enolase, a novel pancreatic ductal adenocarcinoma-associated antigen
[作者:Cappello, P; Tomaino, B; Chiarle, R; Ceruti, P; Novarino, A; Castagnoli, C; Migliorini, P; Perconti, G; Giallongo, A; Milella, M; Monsuro, V; Barbi, S; Scarpa, A; Nistico, P; Giovarelli, M; Novelli, F,期刊:International Journal of Cancer, 页码:639-648 , 文章类型: Article,,卷期:2009年125-3]
- Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with a very poor 5-year survival rate. alpha-Enolase is a glycolytic enzyme that also acts as a surface plasminogen receptor. We find that it is overexpressed in...
- Allorestricted T lymphocytes with a high avidity T-cell receptor towards NY-ESO-1 have potent anti-tumor activity
[作者:Kronig, H; Hofer, K; Conrad, H; Guilaume, P; Muller, J; Schiemann, M; Lennerz, V; Cosma, A; Peschel, C; Busch, DH; Romero, P; Bernhard, H,期刊:International Journal of Cancer, 页码:649-655 , 文章类型: Article,,卷期:2009年125-3]
- The cancer-testis antigen NY-ESO-1 has been targeted as a tomor-associated antigen by immunotherapeutical strategies, such as cancer vaccines. The prerequisite for a T-cell-based therapy is the induction of T cells capab...
- A frequent target of paraproteins in the sera of patients with multiple myeloma and MGUS
[作者:Preuss, KD; Pfreundschuh, M; Ahlgrimm, M; Fadle, N; Regitz, E; Murawski, N; Grass, S,期刊:International Journal of Cancer, 页码:656-661 , 文章类型: Article,,卷期:2009年125-3]
- Antigenic targets of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) paraproteins might play a role in the pathogenesis of these neoplasms. We screened a human fetal brain-derived macr...
- Breastfeeding and breast cancer risk in India: A multicenter case-control study
[作者:Gajalakshmi, V; Mathew, A; Brennan, P; Rajan, B; Kanimozhi, VC; Mathews, A; Mathew, BS; Boffetta, P,期刊:International Journal of Cancer, 页码:662-665 , 文章类型: Article,,卷期:2009年125-3]
- Breast cancer incidence is low in India compared with high-income countries, but it has increased in recent decades, particularly among urban women. The reasons for this pattern are not known although they are likely rel...
- Recent patterns in gastric cancer: A global overview
[作者:Bertuccio, P; Chatenoud, L; Levi, F; Praud, D; Ferlay, J; Negri, E; Malvezzi, M; La Vecchia, C,期刊:International Journal of Cancer, 页码:666-673 , 文章类型: Article,,卷期:2009年125-3]
- Until the mid-1990s, gastric cancer has been the first cause of cancer death worldwide, although rates had been declining for several decades and gastric cancer has become a relatively rare cancer in North America and in...
- Prediagnostic circulating follicle stimulating hormone concentrations and ovarian cancer risk
[作者:McSorley, MA; Alberg, AJ; Allen, DS; Allen, NE; Brinton, LA; Dorgan, JF; Kaaks, R; Rinaldi, S; Helzlsouer, KJ,期刊:International Journal of Cancer, 页码:674-679 , 文章类型: Article,,卷期:2009年125-3]
- Gonadotropins have been indicted in ovarian carcinogenesis but direct evidence has been limited and inconsistent. The aim of this study was to determine the association between prediagnostic levels of follicle stimulatin...
- IgE, allergy, and risk of glioma: Update from the San Francisco Bay Area Adult Glioma Study in the Temozolomide era
[作者:Wiemels, JL; Wilson, D; Patil, C; Patoka, J; Mccoy, L; Rice, T; Schwartzbaum, J; Heimberger, A; Sampson, JH; Chang, S; Prados, M; Wiencke, JK; Wrensch, M,期刊:International Journal of Cancer, 页码:680-687 , 文章类型: Article,,卷期:2009年125-3]
- The consistently observed inverse relationship of allergic conditions with glioma risk and our previous demonstration that immunoglobulin E (IgE) levels also were lower in glioma patients than controls suggest that atopi...
- Restoration of XAF1 expression induces apoptosis and inhibits tumor growth in gastric cancer
[作者:Tu, SP; Liston, P; Cui, JT; Lin, MCM; Jiang, XH; Yang, Y; Gu, Q; Jiang, SH; Lum, CT; Kung, HF; Korneluk, RG; Wong, BCY,期刊:International Journal of Cancer, 页码:688-697 , 文章类型: Article,,卷期:2009年125-3]
- XAF1 (XIAP-associated factor 1) is a novel XIAP binding protein that can antagonize XIAP and sensitize cells to other cell death triggers. Our previous results have shown that aberrant hypermethylation of the CpG sites i...
- Electroporation-mediated IL-12 gene therapy in a transplantable canine cancer model
[作者:Chuang, TF; Lee, SC; Liao, KW; Hsiao, YW; Lo, CH; Chiang, BL; Lin, XZ; Tan, MH; Chu, RM,期刊:International Journal of Cancer, 页码:698-707 , 文章类型: Article,,卷期:2009年125-3]
- Interleukin-12 (IL-12) is effective in treating many types of rodent tumors, but has been unsuccessful in most human clinical trials, suggesting that animal models of more clinical relevance are required for evaluating h...
- Targeted radionuclide therapy of melanoma: Anti-tumoural efficacy studies of a new I-131 labelled potential agent
[作者:Bonnet-Duquennoy, M; Papon, J; Mishellany, F; Labarre, P; Guerquin-Kern, JL; Wu, TD; Gardette, M; Maublant, J; Penault-Llorca, F; Miot-Noirault, E; Cayre, A; Madelmont, JC; Chezal, JM; Moins, N,期刊:International Journal of Cancer, 页码:708-716 , 文章类型: Article,,卷期:2009年125-3]
- In recent years, there has been dramatic worldwide increase in incidence of malignant melanoma. Although localised disease is often curable by surgical excision, metastatic melanoma is inherently resistant to most treatm...
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