- SOCS3 as a tumor suppressor in breast cancer cells, and its regulation by PRL
[作者:Barclay, JL; Anderson, ST; Waters, MJ; Curlewis, JD,期刊:International Journal of Cancer, 页码:1756-1766 , 文章类型: Article,,卷期:2009年124-8]
- Suppressor of cytokine signaling 3 (SOCS3), as a key regulator of cytokine signaling, has the potential to modulate numerous cellular processes. Its involvement in inflammatory disease is well established, and there is i...
- Hepatocarcinogenesis in mice with a conditional knockout of the hepatocyte growth factor receptor c-Met
[作者:Marx-Stoelting, P; Borowiak, M; Knorpp, T; Birchmeier, C; Buchmann, A; Schwarz, M,期刊:International Journal of Cancer, 页码:1767-1772 , 文章类型: Article,,卷期:2009年124-8]
- The receptor for the hepatocyte growth factor/scatter factor (HGF/SF), c-Met, plays a role in tuinour promotion, progression and metastasis. In this study, we analysed chemically induced hepatocarcinogenesis in mice lack...
- HAI-2 is epigenetically downregulated in human hepatocellular carcinoma, and its Kunitz domain type 1 is critical for anti-invasive functions
[作者:Tung, EKK; Wong, CM; Yau, TO; Lee, JMF; Ching, YP; Ng, IOL,期刊:International Journal of Cancer, 页码:1811-1819 , 文章类型: Article,,卷期:2009年124-8]
- Pharmacological de methylation-based gene expression profile analysis is a useful tool to identify epigenetically silenced tumour suppressor genes. HGF activator inhibitor 2 (HAI-2), a serine pro. tease inhibitor, has be...
- Chemokine receptor CXCR4 expression is correlated with VEGF expression and poor survival in soft-tissue sarcoma
[作者:Oda, Y; Tateishi, N; Matono, H; Matsuura, S; Yamamaoto, H; Tamiya, S; Yokoyama, R; Matsuda, S; Iwamoto, Y; Tsuneyoshi, M,期刊:International Journal of Cancer, 页码:1852-1859 , 文章类型: Article,,卷期:2009年124-8]
- The expression of chemokine receptor CXCR4 has been associated with poor prognosis and VEGF expression in several kinds of human malignancy. We measured CXCR4 expression levels in soft-tissue sarcoma and compared them wi...
- Nitric oxide stimulates migration of human endothelial and prostate cancer cells through up-regulation of pleiotrophin expression and its receptor protein tyrosine phosphatase beta/zeta
[作者:Polytarchou, C; Hatziapostolou, M; Polmenidi, E; Mikelis, C; Papadopoulou, A; Parthymou, A; Papadimitriou, E,期刊:International Journal of Cancer, 页码:1785-1793 , 文章类型: Article,,卷期:2009年124-8]
- Pleiotrophin (PTN) is a secreted growth factor involved in angiogenesis and tumor growth. We have recently shown that low concentrations of hydrogen peroxide (HP) stimulate PTN expression, through activation of the trans...
- A-FABP, a candidate progression marker of human transitional cell carcinoma of the bladder, is differentially regulated by PPAR in urothelial cancer cells
[作者:Boiteux, G; Lascombe, I; Roche, E; Plissonnier, ML; Clairotte, A; Bittard, H; Fauconnet, S,期刊:International Journal of Cancer, 页码:1820-1828 , 文章类型: Article,,卷期:2009年124-8]
- Superficial pT1 bladder tumors are characterized by a high risk of recurrence and progression in grade and stage. Few studies provided evidence that loss or adipocyte-fatty acid binding protein (A-FABP) expression was as...
- Radiation-induced cathepsin S is involved in radioresistance
[作者:Seo, HR; Bae, S; Lee, YS,期刊:International Journal of Cancer, 页码:1794-1801 , 文章类型: Article,,卷期:2009年124-8]
- Previous studies have suggested that the production of cathepsin S (CatS), a cysteine protease, was specifically induced in radiation-induced rat mammary tumors. In this study, we further investigate the mechanism by whi...
- The Karyopherin proteins, Crm1 and Karyopherin beta 1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation
[作者:Van der Watt, PJ; Maske, CP; Hendricks, DT; Parker, MI; Denny, L; Govender, D; Birrer, MJ; Leaner, VD,期刊:International Journal of Cancer, 页码:1829-1840 , 文章类型: Article,,卷期:2009年124-8]
- The Karyopherin proteins are involved in nucleo-cytoplasmic trafficking and are critical for protein anti RNA subcellular localization. Recent studies suggest they are important in nuclear envelope component assembly, mi...
- MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors
[作者:Kubo, T; Yamamoto, H; Lockwood, WW; Valencia, I; Sob, J; Peyton, M; Jida, M; Otani, H; Fujii, T; Ouchida, M; Takigawa, N; Kiura, K; Shimizu, K; Date, H; Minna, JD; Varella-Garcia, M; Lam, WL; Gazdar, AF; Toyooka, S,期刊:International Journal of Cancer, 页码:1778-1784 , 文章类型: Article,,卷期:2009年124-8]
- We analyzed MET protein and copy number in NSCLC with or without EGFR mutations untreated with EGFR tyrosine kinase inhibitors (TKIs). MET copy number was examined in 28 NSCLC and 4 human bronchial epithelial cell lines ...
- Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases
[作者:Illemann, M; Bird, N; Majeed, A; Laerum, OD; Lund, LR; Dano, K; Nielsen, BS,期刊:International Journal of Cancer, 页码:1860-1870 , 文章类型: Article,,卷期:2009年124-8]
- Metastatic growth and invasion by colon cancer cells in the liver requires the ability of the cancer cells to interact with the new tissue environment. Plasmin(ogen) is activated on cell surfaces by urokinase-type PA (uP...
- Hypoxia increases normal prostate epithelial cell resistance to receptor-mediated apoptosis via AKT activation
[作者:Walsh, S; Gill, C; O'Neill, A; Fitzpatrick, JM; Watson, RWG,期刊:International Journal of Cancer, 页码:1871-1878 , 文章类型: Article,,卷期:2009年124-8]
- The aging prostate is associated with changes in its vascular structure, which could lead to changes in oxygen levels. hypoxia is in important environmental change that leads to the progression of many cancers mediated t...
- Long-term risk of cardiovascular disease in Hodgkin lymphoma survivors-Retrospective cohort analyses and a concept for prospective intervention
[作者:Andersson, A; Naslund, U; Tavelin, B; Enblad, G; Gustavsson, A; Malmer, B,期刊:International Journal of Cancer, 页码:1914-1917 , 文章类型: Article,,卷期:2009年124-8]
- Previous studies have shown increased cardiovascular mortality as late side effects in Hodgkin lymphoma (HL) patients. This study identifies stratifying risk factors for surveillance and defines concepts for a clinical f...
- Flavonoid intake and ovarian cancer risk in a population-based case-control study
[作者:Gates, MA; Vitonis, AF; Tworoger, SS; Rosner, B; Titus-Ernstow, L; Hankinson, SE; Cramer, DW,期刊:International Journal of Cancer, 页码:1918-1925 , 文章类型: Article,,卷期:2009年124-8]
- Several recent studies have evaluated the association between dietary flavonoid intake and ovarian cancer risk, and all reported significant or suggestive inverse associations with certain flavonoids or flavonoid subclas...
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