- Neural stem cell transplantation can ameliorate the phenotype of a mouse model of spinal muscular atrophy
[作者:Corti, S; Nizzardo, M; Nardini, M; Donadoni, C; Salani, S; Ronchi, D; Saladino, F; Bordoni, A; Fortunato, F; Del Bo, R; Papadimitriou, D; Locatelli, F; Menozzi, G; Strazzer, S; Bresolin, N; Comi, GR,期刊:Journal of clinical investigation, 页码:3316-3330 , 文章类型: Article,,卷期:2008年118-10]
- Spinal muscular atrophy (SMA), a motor neuron disease (MND) and one of the most common genetic causes of infant mortality, currently has no cure. Patients with SMA exhibit muscle weakness and hypotonia. Stem cell transpl...
- GSK-3 beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism (Retracted article. See vol. 118, pg. 3812, 2008)
[作者:Kapoor, M; Liu, SX; Shi-Wen, X; Huh, K; McCann, M; Denton, CP; Woodgett, JR; Abraham, DJ; Leask, A,期刊:Journal of clinical investigation, 页码:3279-3290 , 文章类型: Article,,卷期:2008年118-10]
- Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded by 2 genes, GSK3A and GSK3B. GSK-3 is thought to be involved in tissue repair and fibrogenesis, but it...
- Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated
[作者:Yang, SH; Andres, DA; Spielmann, HP; Young, SG; Fong, LG,期刊:Journal of clinical investigation, 页码:3291-3300 , 文章类型: Article,,卷期:2008年118-10]
- Hutchinson-Gilford progeria syndrome (HGPS), a rare disease that results in what appears to be premature aging, is caused by the production of a mutant form of prelamin A known as progerin. Progerin retains a farnesyl li...
- Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans
[作者:Omenetti, A; Porrello, A; Jung, Y; Yang, L; Popov, Y; Choi, SS; Witek, RP; Alpini, G; Venter, J; Vandongen, HM; Syn, WK; Baroni, GS; Benedetti, A; Schuppan, D; Diehl, AM,期刊:Journal of clinical investigation, 页码:3331-3342 , 文章类型: Article,,卷期:2008年118-10]
- Epithelial-mesenchymal transitions (EMTs) play an important role in tissue construction during embryogenesis, and evidence suggests that this process may also help to remodel some adult tissues after injury. Activation o...
- Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis
[作者:Chun, HJ; Ali, ZA; Kojima, Y; Kundu, RK; Sheikh, AY; Agrawal, R; Zheng, LX; Leeper, NJ; Pearl, NE; Patterson, AJ; Anderson, JP; Tsao, PS; Lenardo, MJ; Ashley, EA; Quertermous, T,期刊:Journal of clinical investigation, 页码:3343-3354 , 文章类型: Article,,卷期:2008年118-10]
- Apelin and its cognate G protein-coupled receptor APJ constitute a signaling pathway with a positive inotropic effect on cardiac function and a vasodepressor function in the systemic circulation. The apelin-APJ pathway a...
- Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury
[作者:Lewis, GD; Wei, R; Liu, E; Yang, E; Shi, X; Martinovic, M; Farrell, L; Asnani, A; Cyrille, M; Ramanathan, A; Shaham, O; Berriz, G; Lowry, PA; Palacios, IF; Tasan, M; Roth, FP; Min, JY; Baumgartner, C; Keshishian, H; Addona, T; Mootha, VK; Rosenzweig, A; Carr, SA; Fifer, MA; Sabatine, MS; Gerszten, RE,期刊:Journal of clinical investigation, 页码:3503-3512 , 文章类型: Article,,卷期:2008年118-10]
- Emerging metabolomic tools have created the opportunity to establish metabolic signatures of myocardial injury. We applied a mass spectrometry-based metabolite profiling platform to 36 patients undergoing alcohol septal ...
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