- Thymus, innate immunity and autoimmune arthritis: Interplay of gene and environment
[作者:Sakaguchi, S; Tanaka, S; Tanaka, A; Ito, Y; Maeda, S; Sakaguchi, N; Hashimoto, M,期刊:FEBS Letters, 页码:3633-3639 , 文章类型: Review,,卷期:2011年585-23]
- A hypomorphic mutation of the gene encoding zeta-associated protein-70 (ZAP-70), a signaling molecule in T cells, produces autoimmune arthritis in mice under a microbially conventional condition but not in a clean enviro...
- Arthritis in space and time - To boldly go!
[作者:Benson, RA; Patakas, A; McQueenie, R; Ross, K; McInnes, IB; Brewer, JM; Garside, P,期刊:FEBS Letters, 页码:3640-3648 , 文章类型: Review,,卷期:2011年585-23]
- Despite the profound impact of biologics on the treatment of rheumatoid arthritis (RA), long lasting disease remission remains elusive. We propose that this is a consequence of failing to target the right molecular pathw...
- Promoting myelin repair and return of function in multiple sclerosis
[作者:Zhang, JY; Kramer, EG; Asp, L; Dutta, DJ; Navrazhina, K; Pham, T; Mariani, JN; Argaw, AT; Melendez-Vasquez, CV; John, GR,期刊:FEBS Letters, 页码:3813-3820 , 文章类型: Review,,卷期:2011年585-23]
- Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Conduction block in demyelinated axons underlies early neurological symptoms, but axonal transection and neuronal loss are believed to be respo...
- Regulation of remyelination in multiple sclerosis
[作者:Hanafy, KA; Sloane, JA,期刊:FEBS Letters, 页码:3821-3828 , 文章类型: Review,,卷期:2011年585-23]
- Multiple sclerosis is a common demyelinating disease that worsens over the course of disease, a significant problem in clinical management. Disability in MS is significantly promoted by poor repair and remyelination of l...
- The role of immune semaphorins in multiple sclerosis
[作者:Okuno, T; Nakatsuji, Y; Kumanogoh, A,期刊:FEBS Letters, 页码:3829-3835 , 文章类型: Review,,卷期:2011年585-23]
- The nervous and immune systems have similar functional characteristics. Both have an intricate network of synaptic connections and an exquisite communication system that enable intercellular signal transduction. Although...
- Ion channels in autoimmune neurodegeneration
[作者:Ehling, P; Bittner, S; Budde, T; Wiendl, H; Meuth, SG,期刊:FEBS Letters, 页码:3836-3842 , 文章类型: Review,,卷期:2011年585-23]
- Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances ...
- Toll-like receptors in rheumatic diseases: Are we paying a high price for our defense against bugs?
[作者:Santegoets, KCM; van Bon, L; van den Berg, WB; Wenink, MH; Radstake, TRDJ,期刊:FEBS Letters, 页码:3660-3666 , 文章类型: Review,,卷期:2011年585-23]
- In the last decade Toll-like receptor (TLR) research has led to new insights in the pathogenesis of many rheumatic diseases. In autoimmune diseases like systemic lupus erythematosus, rheumatoid arthritis and systemic scl...
- MicroRNAs in rheumatoid arthritis
[作者:Ceribelli, A; Nahid, MA; Satoh, M; Chan, EKL,期刊:FEBS Letters, 页码:3667-3674 , 文章类型: Review,,卷期:2011年585-23]
- Rheumatoid arthritis (RA) is a chronic and severe autoimmune disease that affects joint tissues, bone, and cartilage. However, the pathogenesis of RA is still unclear. Autoantibodies such as rheumatoid factor and anti-cy...
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