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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共24条记录   Denatured bactericidal proteins: Active per se, or reservoirs of active peptides? [作者：D'Alessio, G,期刊：FEBS Letters, 页码：2403-2404 , 文章类型： Article，,卷期：2011年585-15] According to the structure-to-function paradigm proteins fold into a 3D structure for exerting their functions. Intrinsically destructured proteins with important biological functions have been identified and studied, bu... SUMOylation of Blimp-1 promotes its proteasomal degradation [作者：Shimshon, L; Michaeli, A; Hadar, R; Nutt, SL; David, Y; Navon, A; Waisman, A; Tirosh, B,期刊：FEBS Letters, 页码：2405-2409 , 文章类型： Article，,卷期：2011年585-15] B lymphocyte induced maturation protein-1 (Blimp-1) is a transcription repressor of the Krueppel-like family. Blimp-1 plays important roles in developmental processes, such as of germ cells and hair follicle stem cells. ... NELL-1 binds to APR3 affecting human osteoblast proliferation and differentiation [作者：Zou, X; Shen, J; Chen, F; Ting, K; Zheng, Z; Pang, S; Zara, JN; Adams, JS; Soo, C; Zhang, XL,期刊：FEBS Letters, 页码：2410-2418 , 文章类型： Article，,卷期：2011年585-15] Nel-like protein 1 (NELL-1) is an osteoinductive molecule associated with premature calvarial suture closure. Here we identified apoptosis related protein 3 (APR3), a membrane protein known as a proliferation suppressor,... Recombinant human cytoplasmic dynein heavy chain 1 and 2: Observation of dynein-2 motor activity in vitro [作者：Ichikawa, M; Watanabe, Y; Murayama, T; Toyoshima, YY,期刊：FEBS Letters, 页码：2419-2423 , 文章类型： Article，,卷期：2011年585-15] Cytoplasmic dynein is a microtubule (MT) motor protein comprising two classes: dynein-1 and dynein-2. We purified recombinant human dynein-1 and dynein-2 from HEK-293 cells by expressing the streptavidin-binding peptide-... Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation [作者：Ferreira, N; Saraiva, MJ; Almeida, MR,期刊：FEBS Letters, 页码：2424-2430 , 文章类型： Article，,卷期：2011年585-15] Several natural polyphenols with potent inhibitory effects on amyloid fibril formation have been reported. Herein, we studied modulation of transthyretin (TTR) fibrillogenesis by selected polyphenols. We demonstrate that... A single amino acid change in the transmembrane domain of the VirB8 protein affects dimerization, interaction with VirB10 and Brucella suis virulence [作者：Andrieux, L; Bourg, G; Pirone, A; O'Callaghan, D; Patey, G,期刊：FEBS Letters, 页码：2431-2436 , 文章类型： Article，,卷期：2011年585-15] VirB8 is a critical component of the Brucella suis type IV secretion system (T4SS). We previously showed that the transmembrane (TM) domain plays an essential role in interactions of this protein with itself and the othe... FSH acts on the proliferation of type A spermatogonia via Nur77 that increases GDNF expression in the Sertoli cells [作者：Ding, LJ; Yan, GJ; Ge, QY; Yu, F; Zhao, X; Diao, ZY; Wang, ZQ; Yang, ZZ; Sun, HX; Hu, YL,期刊：FEBS Letters, 页码：2437-2444 , 文章类型： Article，,卷期：2011年585-15] The molecular mechanism responsible for the regulation of GDNF in Sertoli cells remains largely unknown. In the present study, FSH induced the expression of Nur77 and GDNF in mouse testis tissue and human fetal Sertoli c... Evidence for direct binding of glycerol to photosystem I [作者：Hussels, M; Brecht, M,期刊：FEBS Letters, 页码：2445-2449 , 文章类型： Article，,卷期：2011年585-15] The interaction between glycerol and photosystem I (PSI) was investigated using low temperature single-molecule spectroscopy. PSI complexes were dissolved in three different solutions: in buffer solution, in 66% glycerol... Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4 [作者：Galea, GL; Sunters, A; Meakin, LB; Zaman, G; Sugiyama, T; Lanyon, LE; Price, JS,期刊：FEBS Letters, 页码：2450-2454 , 文章类型： Article，,卷期：2011年585-15] Sclerostin is a potent inhibitor of bone formation which is down-regulated by mechanical loading. To investigate the mechanisms involved we subjected Saos2 human osteoblastic cells to short periods of dynamic strain and ... The immediate early genes Fos and Egr1 become STAT1 transcriptional targets in the absence of STAT3 [作者：Schiavone, D; Avalle, L; Dewilde, S; Poli, V,期刊：FEBS Letters, 页码：2455-2460 , 文章类型： Article，,卷期：2011年585-15] Signal transducer and activators of transcription (STAT) 1 and STAT3 cross-regulate their activity downstream of gp130 cytokines, and eliminating STAT3 leads to IFN-gamma-like responses to IL-6 correlating with prolonged... Asparagine 405 of heparin lyase II prevents the cleavage of glycosidic linkages proximate to a 3-O-sulfoglucosamine residue [作者：Zhao, WJ; Garron, ML; Yang, B; Xiao, ZP; Esko, JD; Cygler, M; Linhardt, RJ,期刊：FEBS Letters, 页码：2461-2466 , 文章类型： Article，,卷期：2011年585-15] Heparin and heparan sulfate contain a rare 3-O-sulfoglucosamine residue critical for anticoagulation and virus recognition, respectively. The glycosidic linkage proximate to this 3-O-sulfoglucosamine is resistant to clea... Epigenetic regulation of microRNA-375 and its role in melanoma development in humans [作者：Mazar, J; DeBlasio, D; Govindarajan, SS; Zhang, SJ; Perera, RJ,期刊：FEBS Letters, 页码：2467-2476 , 文章类型： Article，,卷期：2011年585-15] To identify epigenetically regulated miRNAs in melanoma, we treated a stage 3 melanoma cell line WM1552C, with 5AzadC and/or 4-PBA. Several hypermethylated miRNAs were detected, one of which, miR-375, was highly methylat... A small cytoplasmic region adjacent to the fourth transmembrane segment of the alpha 7 nicotinic receptor is essential for its biogenesis [作者：Criado, M; Mulet, J; Gerber, S; Sala, S; Sala, F,期刊：FEBS Letters, 页码：2477-2480 , 文章类型： Article，,卷期：2011年585-15] Deletion of a small cytoplasmic fragment close to the fourth transmembrane segment of the nicotinic alpha 7 receptor (Glu437 to Arg447) abolished membrane expression. Different single mutants showed moderate to strong de... Biosynthesis and secretion of mouse cysteine-rich with EGF-like domains 2 [作者：Oh-hashi, K; Kunieda, R; Hirata, Y; Kiuchi, K,期刊：FEBS Letters, 页码：2481-2487 , 文章类型： Article，,卷期：2011年585-15] In this study, we found that Cysteine-rich with EGF-like domains 2 (CRELD2), a novel endoplasmic reticulum stress-inducible protein, is not only localized in the ER-Golgi apparatus but also spontaneously secreted. Deleti... RNA interference-produced autoregulation of inducible nitric oxide synthase expression [作者：Feng, CZ; Cao, L; Zuo, ZY,期刊：FEBS Letters, 页码：2488-2492 , 文章类型： Article，,卷期：2011年585-15] Vector-mediated delivery of short-hairpin RNA (shRNA) to regulate gene expression holds a great therapeutic promise. We hypothesize that gene expression can be autoregulated with RNA interference. We used inducible nitri... Cyclin T2: A novel miR-15a target gene involved in early spermatogenesis [作者：Teng, Y; Wang, Y; Fu, J; Cheng, XW; Miao, SY; Wang, LF,期刊：FEBS Letters, 页码：2493-2500 , 文章类型： Article，,卷期：2011年585-15] MicroRNAs (miRNAs) are posttranscriptional modulators of gene expression that play important roles in various biological processes. Spermatogenesis is a highly regulated process in which diploid spermatogonia eventually ...